Loading
This pathological study found that the cancer underlying Paget disease of the nipple is often multifocal and spread away from the nipple, which is why full imaging and careful surgical planning are needed rather than simple nipple excision.
Review of 70 mastectomy specimens with Paget disease of the nipple, mapping the extent and location of the underlying in situ and invasive carcinoma.
Most cases had underlying carcinoma, frequently multifocal and often distant from the nipple, with a high proportion of high-grade and HER2-positive tumours, arguing that Paget disease marks a higher-risk breast.
Breast MRI to map disease and central excision with clear margins or mastectomy, rather than removing the nipple alone, follow from findings like these.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/