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The Jackson Laboratory Cancer Center
The Jackson Laboratory in Maine breeds the world's genetically defined laboratory mice, including the immunodeficient NSG strain behind patient-derived xenograft research, and has held NCI basic cancer centre status since 1983; its PDX repository is open to academic and industry researchers.
Also called: JAX
Overview
Founded in 1929 by Clarence Cook Little, The Jackson Laboratory is the world's principal source of genetically defined laboratory mice, including the immunodeficient NSG strain that underpins patient-derived xenograft research, and has held NCI basic laboratory designation since 1983. Its cancer centre studies cancer genetics and genomics, the tumour microenvironment and drug response using mouse and PDX resources, with a large PDX repository available to academic and industry researchers. JAX Genomic Medicine in Farmington, Connecticut, extends the institute into human genomics and computational biology, and the Mouse Genome Informatics database is a core community resource.
Location
Bar Harbor, ME, US
Type
research institute
Website
Newsweek 2026 oncology rank
Not in top 300 listing used
NCI designation
basic
OnCo score
#283 · 24 points (0 Newsweek + 8 NCI + 16 from 8 linked objects) · ranking
Research output
From OpenAlex, oncology works in the last five years (2022 to 2026, current year in progress); counted on 2026-10-08.
Matched to The JAX Cancer Center, including child institutions. 4 works · 39 citations · 50% open access · 25% clinical trials · 25% reviews.
Oncology works per year
22022
12023
12024
02025
02026
Most works
- Guangwen Ren2 works
- Carlos M. Leon1 works
- Luigi Nezi1 works
- Edison T. Liu1 works
- Martin H. Shaefer1 works
- Danilo Cagnina1 works
- Carlotta Catozzi1 works
- Nicola Fazio1 works
- Muneer G. Hasham1 works
- Heather Sheppard1 works
Most cited
| Work | Journal | Year | Citations |
|---|---|---|---|
| Mouse models for immuno-oncology | Trends in cancer | 2023 | 39 |
| Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression | Research Square | 2024 | 0 |
| Abstract 1863: Mouse strain variations in drug-induced lung stromal responses conference abstract · 10.1158/1538-7445.am2022-1863 | Cancer Research | 2022 | 0 |
| Abstract P017: Intra-tumoral infiltration of GZMKhigh CD8+ T effector memory cells is associated with poor clinical outcome in early-stage colo-rectal cancer conference abstract · 10.1158/2326-6074.tumimm21-p017 | Cancer Immunology Research | 2022 | 0 |
Programmes
3- Mouse models and PDX resource
- Cancer genetics and genomics
- Mouse Genome Informatics
People
1Connected
9Similar pages
- IdeaMulti-centre randomised animal trials before committing to a human trial
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).
- IdeaPre-specified sample sizes for animal studies; no more 'representative' experiments
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
- IdeaBarcode patient-derived tumours to watch which clones win under each drug
Shares Patient-derived xenografts, CRISPR functional genomics, Lab models that fail to predict what happens in patients.
- IdeaPre-register animal efficacy studies like clinical trials
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).
- IdeaMake bespoke mouse cancer models in weeks with in vivo gene editing
Shares Patient-derived xenografts, CRISPR functional genomics, Lab models that fail to predict what happens in patients.
- IdeaA home for the animal and organoid experiments that failed
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).
- IdeaAudit animal studies for randomisation and blinding, published by institution
Shares Patient-derived xenografts, Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
- IdeaProve the cell line is what you say it is, or the paper does not run
Shares Preclinical results do not reproduce, Lab models that fail to predict what happens in patients.
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Sources
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
jax.org · 1
A source that has moved or gone is reported by the weekly link check. /audit/