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Children wait years for drugs because adult trials come first, even when the target belongs to a childhood cancer. Some drugs should start with children.
Paediatric oncology drug development is usually a downstream obligation, with paediatric plans triggered by adult programmes. For fusion-driven and developmental-lineage targets such as ALK in neuroblastoma, NTRK fusions, H3K27M-altered glioma and specific sarcoma fusions, the disease biology is paediatric and adult data add little. A paediatric-first pathway with matched incentives would compress timelines by years.
Shares Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first, Children's Oncology Group (COG), Incentives reward me-too drugs and marginal gains, Neuroblastoma (paediatric).
Shares Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first, Children's Oncology Group (COG), Incentives reward me-too drugs and marginal gains, Neuroblastoma (paediatric).
Shares Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first, Regulatory divergence between regions, Neuroblastoma (paediatric), Rare and paediatric cancers without markets.
Shares Dordaviprone, H3 K27M (diffuse midline glioma), Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first, Rare and paediatric cancers without markets.
Shares Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first, Children's Oncology Group (COG), Neuroblastoma (paediatric), Rare and paediatric cancers without markets.
Shares Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first, Children's Oncology Group (COG), Neuroblastoma (paediatric), Rare and paediatric cancers without markets.
Shares Rare cancers are not so rare: the rare cancer burden in Europe, Neuroblastoma (paediatric), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
Shares Rare cancers are not so rare: the rare cancer burden in Europe, Regulatory divergence between regions, Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
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