Loading
SHR-A1921 is an experimental drug that delivers chemotherapy to TROP2-bearing cells. Early solid-tumor findings are distinct from the later trials testing its comparative benefit.
The 2025 Cancer Cell publication reports a first-in-human phase 1 study, NCT05154604, in 391 patients with pretreated advanced or metastatic solid tumors. Overall ORR was 24.8% (95% CI 20.6 to 29.4), across several different tumor cohorts. This pooled rate is not a TNBC-specific estimate. Grade 3 or higher treatment-related events occurred in 132/391 patients (33.8%), including stomatitis in 57/391 (14.6%). The reported lack of a significant expression-efficacy correlation in this study does not validate universal expression independence or a companion diagnostic. Later registered phase 3 development is separate from this uncontrolled evidence.
TROP2-targeted antibody-drug conjugate, identified in the primary first-in-human publication. Connects to TROP2.
1.SHR-A1921's antibody arm binds TROP2 on the surface of the cancer cell.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"SHR-A1921" OR ABSTRACT:"SHR-A1921") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SHR-A1921, not a curated reading list.
Shares A Phase IB/II Clinical Study of SHR-9839 for Injection Combined With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors, Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Shares Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Shares Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Shares Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Shares Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Shares Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Shares Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Shares Jiangsu Hengrui Pharmaceuticals and the tag pipeline.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/