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FDA018-ADC, also called F0024, is an experimental drug that carries chemotherapy to TROP2-bearing cells. Early response results do not establish a benefit over standard treatment.
NCT05174637 identifies F0024 as an alternative name for FDA018-ADC. ASCO 2024 abstract e13131 reports 62 treated patients at the October 8, 2023 cutoff. At 10 mg/kg, 11/29 efficacy-evaluable TNBC patients had partial responses (ORR 37.9%, 95% CI 20.7 to 57.7). Grade 3 or higher treatment-related adverse events occurred in 32/62 patients (51.6%), including grade 3 neutropenia in 45.2%. The selected dose cohort is not a randomized efficacy comparison. Later phase 3 registration is separate from this first-in-human evidence.
TROP2-directed ADC delivering SN-38, the active metabolite of irinotecan. Connects to TROP2.
1.FDA018-ADC's antibody arm binds TROP2 on the surface of the cancer cell.
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Query for this drug: (TITLE:"FDA018-ADC" OR ABSTRACT:"FDA018-ADC" OR TITLE:"FDA018" OR ABSTRACT:"FDA018" OR TITLE:"F0024" OR ABSTRACT:"F0024" OR TITLE:"FDA018-Antibody-drug Conjugate" OR ABSTRACT:"FDA018-Antibody-drug Conjugate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FDA018-ADC, not a curated reading list.
Shares TROP2, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares TROP2, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares TROP2, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares TROP2, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares TROP2, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares TROP2, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares TROP2 and the tag pipeline.
Shares TROP2 and the tag pipeline.
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