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Threshold Pharmaceuticals
Threshold developed evofosfamide, a drug switched on only in the oxygen-starved parts of tumours; two phase 3 trials in pancreatic cancer and sarcoma failed in 2015 and the company merged away.
Also called: Threshold Pharmaceuticals, Inc.
Overview
Threshold Pharmaceuticals, founded in 2001 in San Francisco, pursued hypoxia-activated prodrugs, chiefly evofosfamide (TH-302), a bromo-isophosphoramide mustard released in hypoxic tumour tissue and partnered with Merck KGaA. The MAESTRO trial in pancreatic cancer and the TH CR-406 trial in soft tissue sarcoma both missed their survival endpoints in 2015; Threshold later merged with Molecular Templates. Its trials remain on ClinicalTrials.gov under Threshold as lead sponsor.
Headquarters
San Francisco, CA, US
Scorecard
All companies#452of 1245 companies, score 7
- modalities +2
- registry trials +8
- failures -3
0 approved, 0 in phase 3, 0 earlier, 0 targets, 15 registry studies. Formula on the scorecards page.
Type
Stage
Wound down
Website
Founded
2001
Products
1NegativeHypoxia-activated prodrug (small molecule alkylating agent)
Evofosfamide was the most advanced hypoxia-activated drug, designed to kill the oxygen-starved tumour cells radiotherapy and chemotherapy miss, but it failed both of its phase 3 trials in 2015.
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cancers
technologies
drugs
NegativeHypoxia-activated prodrug (small molecule alkylating agent)
companies
terms
Sources
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
ClinicalTrials.gov · 1
thresholdpharm.com · 1
wikidata.org · 1
A source that has moved or gone is reported by the weekly link check. /audit/
ProvenanceLast edited 2026-09-17 · Jude Gomila · Reverse links for orphaned drugs and companies · diff · file
Sourced, not expert-reviewed