Myeloid leukaemia of Down syndrome · Countries and centres


Sylvester Comprehensive Cancer Center, University of Miami Miami, FL · cancer center	United States	NCI clinical	1,511	13,764	MRD / molecular residual disease testing Proton therapy Proton therapy machines: cyclotrons, synchrotrons and single-room systems	-
Cancer Center Clínica Universidad de Navarra / CIMA Pamplona · cancer center	Spain	none recorded	775	11,529	Proton therapy MRD / molecular residual disease testing Immune checkpoint inhibitors TIL therapy +1	-
Hospital Universitario 12 de Octubre Madrid · hospital	Spain	none recorded	765	13,961	T-cell engagers (bispecific)CAR-T cell therapy MRD / molecular residual disease testing Immune checkpoint inhibitors	-
St. Jude Children's Research Hospital Memphis, TN · cancer center	United States	NCI comprehensive	627	8,335	Proton therapy Whole-exome & whole-genome sequencing CAR-T cell therapy Proton therapy machines: cyclotrons, synchrotrons and single-room systems	-
INCLIVA Biomedical Research Institute / Hospital Clínico Universitario de Valencia Valencia · hospital	Spain	none recorded	403	4,139	Liquid biopsy (ctDNA)MRD / molecular residual disease testing Comprehensive genomic profiling	-
IUCT Oncopole (Institut Universitaire du Cancer de Toulouse) Toulouse · cancer center	France	none recorded	156	1,962	MRD / molecular residual disease testing CAR-T cell therapy Bispecific antibodies IMRT / IGRT (modern external beam)	-
Cancer Research UK Manchester Institute Manchester · research institute	United Kingdom	none recorded	80	2,627	Liquid biopsy (ctDNA)Patient-derived xenografts MRD / molecular residual disease testing Comprehensive genomic profiling	-
Sydney Children's Hospitals Network / Children's Cancer Institute Sydney · hospital	Australia	none recorded	76	883	Whole-exome & whole-genome sequencing RNA sequencing & expression profiling DNA methylation profiling Functional (ex vivo) drug testing +1	-
American Society of Hematology Washington, DC · consortium	United States	none recorded	2	1	CAR-T cell therapy Bispecific antibodies MRD / molecular residual disease testing	-
Cancer Research UK Cambridge Centre / CRUK Cambridge Institute Cambridge · cancer center	United Kingdom	none recorded	not matched	-	Liquid biopsy (ctDNA)MRD / molecular residual disease testing Single-cell & spatial profiling Whole-exome & whole-genome sequencing +1	-
Children's Cancer Hospital Egypt 57357 Cairo · cancer center	Egypt	none recorded	not matched	-	Allogeneic (off-the-shelf) cell therapy IMRT / IGRT (modern external beam)MRD / molecular residual disease testing	-
European Hematology Association The Hague · consortium	Netherlands	none recorded	not matched	-	CAR-T cell therapy Bispecific antibodies MRD / molecular residual disease testing	-
FDA Oncology Center of Excellence Silver Spring, MD · government	United States	none recorded	not matched	-	Companion diagnostics MRD / molecular residual disease testing	-
National Cancer Center Hospital East Kashiwa, Chiba · cancer center	Japan	none recorded	not matched	-	Proton therapy Comprehensive genomic profiling Liquid biopsy (ctDNA)MRD / molecular residual disease testing +2	-