{"registry": "ISRCTN", "registryId": "ISRCTN49127736", "source": "https://www.isrctn.com/ISRCTN49127736", "apiSource": "https://www.isrctn.com/api/trial/ISRCTN49127736/format/default", "fetchedAt": "2026-10-07T17:00:55.350971Z", "license": "CC BY 4.0", "licenseSource": "https://www.isrctn.com/page/faqs#licence-to-post", "study": {"title": "European Randomised study of Screening for Prostate Cancer", "scientificTitle": "European Randomised study of Screening for Prostate Cancer", "acronym": "ERSPC", "hypothesis": "Screening causes a difference in prostate cancer mortality of 20% or more.", "primaryOutcome": "Prostate cancer mortality compared between the screened and the non-screened group of men at risk.", "secondaryOutcome": "1. Progression-free (tumour free) survival\n2. Survival free of metastatic disease\n3. Quality of life in the screened and non-screened populations", "intervention": "\n\tProstate Specific Antigen (PSA) determination followed by Digital Rectal Examination (DRE) and prostate biopsy if PSA greater than or equal to 3.\n\tOther\n\t\n\t\n      ", "condition": "\n\tProstate cancer\n\tCancer\n\tProstate cancer\n      ", "studyDesign": "Multicentre randomised active-controlled parallel-group trial", "overallEndDate": "2010-12-31T00:00:00.000Z", "clinicalTrialsGovNumber": "", "lastUpdated": "2026-08-10T13:40:22.193694702Z", "eligibility": {"inclusion": "Males aged 55 - 74 years (including age 74)", "exclusion": "Previous diagnosis of prostate cancer", "ageRange": "Senior", "gender": "Male", "participantType": "Patient"}, "recruitment": {"recruitmentStart": "1991-10-01T00:00:00.000Z", "recruitmentEnd": "2010-12-31T00:00:00.000Z", "recruitmentStatusOverride": "", "recruitmentStartStatusOverride": "", "targetEnrolment": "251133", "totalFinalEnrolment": "0"}, "countries": ["Belgium", "Finland", "France", "Italy", "Netherlands", "Spain", "Sweden", "Switzerland"], "locations": [{"name": "Erasmus Medical Center", "city": "Rotterdam", "state": "", "country": "Netherlands", "zip": "3000 CA"}], "sponsors": [{"organisation": "Erasmus Medical Centre (Netherlands)", "sponsorType": "University/education", "rorId": "https://ror.org/018906e22"}], "funders": [{"name": "The Netherlands Organisation for Health Research and Development (ZonMw) (Netherlands)"}, {"name": "European Union (EU) (Belgium) - Fifth and Sixth Framework Programmes (FP5, FP6)"}, {"name": "The National Cancer Fund (Koningin Wilhelmina Fonds [KWF]) (Netherlands)"}]}, "studySha256": "226d547027aa570a142a0d4b0e0dd39bc95d08b1846bac1b65384e078f5a2e1c"}