{"registry": "ISRCTN", "registryId": "ISRCTN28352761", "source": "https://www.isrctn.com/ISRCTN28352761", "apiSource": "https://www.isrctn.com/api/trial/ISRCTN28352761/format/default", "fetchedAt": "2026-10-07T17:01:37.140084Z", "license": "CC BY 4.0", "licenseSource": "https://www.isrctn.com/page/faqs#licence-to-post", "study": {"title": "Multicentre randomised trial of 'once only' flexible sigmoidoscopy screening for prevention of bowel cancer morbidity and mortality", "scientificTitle": "Multicentre randomised trial of 'once only' flexible sigmoidoscopy screening for prevention of bowel cancer morbidity and mortality", "acronym": "UKFSST", "hypothesis": "Primary aims:\n1. To quantify the reduction in incidence and mortality\n2. To determine the duration of efficacy of a single flexible sigmoidoscopy\n3. To determine the optimum age for the examination\n4. To evaluate health service research implications to permit an informed decision at the end of the trial about the suitability for implementation within a national screening programme\n\nThe criteria to be evaluated include:\n1. Uptake, acceptability and impact\n2. Quality control of the procedure\n3. Cost-effectiveness", "primaryOutcome": "Incidence, mortality from colorectal cancer", "secondaryOutcome": "Psychological morbidity, costs to the NHS", "intervention": "\n\t'Once only' flexible sigmoidoscopy screening/control\n\tOther\n\t\n\t\n      ", "condition": "\n\tColorectal cancer\n\tCancer\n\tColorectal\n      ", "studyDesign": "Randomised controlled trial", "overallEndDate": "2028-06-30T00:00:00.000Z", "clinicalTrialsGovNumber": "", "lastUpdated": "2026-07-03T10:33:50.38562535Z", "eligibility": {"inclusion": "All 55-64 year old men and women from selected general practices", "exclusion": "1. If incapable of providing informed consent\n2. Patients with a personal or family history of bowel cancer  (greater than two family members)\n3. A recent sigmoidoscopy or colonoscopy\n4. Severe illness or life expectancy of less than 5 years", "ageRange": "Adult", "gender": "All", "participantType": "Patient"}, "recruitment": {"recruitmentStart": "1995-07-01T00:00:00.000Z", "recruitmentEnd": "2014-02-28T00:00:00.000Z", "recruitmentStatusOverride": "", "recruitmentStartStatusOverride": "", "targetEnrolment": "170000", "totalFinalEnrolment": "167882"}, "countries": ["United Kingdom", "England"], "locations": [{"name": "Imperial College London", "city": "London", "state": "", "country": "England", "zip": "W2 1NY"}], "sponsors": [{"organisation": "Medical Research Council (MRC) (UK)", "sponsorType": "Research council"}], "funders": [{"name": "Medical Research Council (MRC) (UK)", "fundRef": "http://dx.doi.org/10.13039/501100000265"}]}, "studySha256": "7bd200e817eede33ac6c5cf213b0982e58c1c44a1af06bf2a51a597c3931b03f"}