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synthetic-lethality
No description yet: the sentence for this tag has not been written. 2 records carry it: 1 target, 1 person.
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2 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
PARP PARP1 PARP inhibitors block DNA repair. Some cancers with defective repair are especially vulnerable, but the gene, disease setting and treatment combination determine which evidence applies. | Ovarian cancer, Triple-negative breast cancer, HR-positive / HER2-negative breast cancer | none | none | ||
Thomas Helleday Professor of Chemical Biology, Karolinska Institutet; Professor, University of Sheffield · Karolinska University Hospital Co-discovered that PARP inhibitors kill BRCA-deficient cells, the synthetic lethality behind olaparib and its successors. | none | none | parp, discovery |
