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"title": "Benefit from perioperative enfortumab vedotin-pembrolizumab in cisplatin-eligible MIBC.",
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"venue": "FDA",
"records": [
{
"id": "lenvatinib",
"kind": "drug",
"name": "Lenvatinib",
"url": "https://onco.cc/drugs/lenvatinib/"
},
{
"id": "belzutifan",
"kind": "drug",
"name": "Belzutifan",
"url": "https://onco.cc/drugs/belzutifan/"
},
{
"id": "rcc",
"kind": "cancer",
"name": "Renal cell carcinoma",
"url": "https://onco.cc/cancers/rcc/"
},
{
"id": "clear-cell-rcc",
"kind": "cancer",
"name": "Clear cell renal cell carcinoma",
"url": "https://onco.cc/cancers/clear-cell-rcc/"
},
{
"id": "spinal-cord-tumours",
"kind": "cancer",
"name": "Spinal cord tumours",
"url": "https://onco.cc/cancers/spinal-cord-tumours/"
},
{
"id": "pancreatic-net",
"kind": "cancer",
"name": "Pancreatic neuroendocrine tumours",
"url": "https://onco.cc/cancers/pancreatic-net/"
},
{
"id": "hereditary-ppgl",
"kind": "cancer",
"name": "Hereditary pheochromocytoma and paraganglioma",
"url": "https://onco.cc/cancers/hereditary-ppgl/"
},
{
"id": "hcc",
"kind": "cancer",
"name": "Hepatocellular carcinoma",
"url": "https://onco.cc/cancers/hcc/"
},
{
"id": "hcc-advanced",
"kind": "cancer",
"name": "Advanced hepatocellular carcinoma",
"url": "https://onco.cc/cancers/hcc-advanced/"
},
{
"id": "hcc-intermediate",
"kind": "cancer",
"name": "Intermediate hepatocellular carcinoma",
"url": "https://onco.cc/cancers/hcc-intermediate/"
},
{
"id": "thyroid",
"kind": "cancer",
"name": "Thyroid cancer",
"url": "https://onco.cc/cancers/thyroid/"
}
]
}
},
{
"id": "https://onco.cc/newsletter/2026-10-07/#onco-edge-issue",
"url": "https://onco.cc/newsletter/2026-10-07/",
"title": "OnCo weekly, 2026-10-07",
"content_text": "898 changelog entries, 1 upcoming date, 26 corrections.",
"date_published": "2026-10-07T00:00:00Z",
"tags": [
"issue"
],
"_onco": {
"kind": "issue",
"date": "2026-10-07",
"precision": "day",
"venue": "OnCo weekly issue",
"records": []
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lirafugratinib-previously-treated-unresectable-locally-advanced-or-metastatic#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lirafugratinib-previously-treated-unresectable-locally-advanced-or-metastatic",
"title": "FDA approves lirafugratinib for previously treated, unresectable, locally advanced or metastatic cholangiocarcinoma",
"content_text": "On September 23, 2026, the Food and Drug Administration approved lirafugratinib (Lyrfigtu, Elevar Therapeutics, Inc.), a kinase inhibitor, for the treatment of adults with previously treated unresectable, locally advanced or metastatic cholangiocarcinoma harboring a fibroblast growth factor receptor 2 (FGFR2) gene fusion or other rearrangement.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-09-23",
"precision": "day",
"venue": "FDA",
"records": [
{
"id": "lirafugratinib",
"kind": "drug",
"name": "Lirafugratinib",
"url": "https://onco.cc/drugs/lirafugratinib/"
},
{
"id": "cholangiocarcinoma",
"kind": "cancer",
"name": "Biliary tract cancer",
"url": "https://onco.cc/cancers/cholangiocarcinoma/"
},
{
"id": "fgfr2",
"kind": "target",
"name": "FGFR2",
"url": "https://onco.cc/targets/fgfr2/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.07.26364583#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.07.26364583",
"title": "A tuneable structural switch controls RNF213 activity and is bypassed in Moyamoya disease",
"content_text": "Posted on medRxiv on 11 October 2026; not peer reviewed; matched RNF213.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "medRxiv",
"doi": "10.64898/2026.10.07.26364583",
"records": [
{
"id": "rnf213",
"kind": "target",
"name": "RNF213",
"url": "https://onco.cc/targets/rnf213/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10880389/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10880389/v1",
"title": "Carotid Body Paraganglioma Presenting With Paroxysmal Hypertension: A Case Report",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched CCDC6.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10880389/v1",
"records": [
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.05.756761#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.05.756761",
"title": "CD19 CAR Engineered T Regulatory Cells Promote Durable Immune Tolerance in Experimental Systemic Lupus Erythematosus",
"content_text": "Posted on bioRxiv on 11 October 2026; not peer reviewed; matched CAR-T cell therapy.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.05.756761",
"records": [
{
"id": "car-t",
"kind": "technology",
"name": "CAR-T cell therapy",
"url": "https://onco.cc/technologies/car-t/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10936687/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10936687/v1",
"title": "Collapsing Focal Segmental Glomerulosclerosis Progression to ESRD Following Combination Therapy with Pembrolizumab and Enfortumab Vedotin: A Case Report",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Cisplatin, Rituximab and Platinum agents.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10936687/v1",
"records": [
{
"id": "cisplatin",
"kind": "drug",
"name": "Cisplatin",
"url": "https://onco.cc/drugs/cisplatin/"
},
{
"id": "rituximab",
"kind": "drug",
"name": "Rituximab",
"url": "https://onco.cc/drugs/rituximab/"
},
{
"id": "platinum",
"kind": "technology",
"name": "Platinum agents",
"url": "https://onco.cc/technologies/platinum/"
},
{
"id": "adc",
"kind": "technology",
"name": "Antibody-drug conjugate",
"url": "https://onco.cc/technologies/adc/"
},
{
"id": "checkpoint-inhibitor",
"kind": "technology",
"name": "Immune checkpoint inhibitors",
"url": "https://onco.cc/technologies/checkpoint-inhibitor/"
},
{
"id": "egfr",
"kind": "target",
"name": "EGFR",
"url": "https://onco.cc/targets/egfr/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11098261/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11098261/v1",
"title": "Differential Immune Dynamics in Large B-Cell Lymphoma Patients Treated With Axi-Cel and Tisa-Cel Car-T Cell Products",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Tisagenlecleucel, CAR-T cell therapy and CD19.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11098261/v1",
"records": [
{
"id": "tisagenlecleucel",
"kind": "drug",
"name": "Tisagenlecleucel",
"url": "https://onco.cc/drugs/tisagenlecleucel/"
},
{
"id": "car-t",
"kind": "technology",
"name": "CAR-T cell therapy",
"url": "https://onco.cc/technologies/car-t/"
},
{
"id": "cd19",
"kind": "target",
"name": "CD19",
"url": "https://onco.cc/targets/cd19/"
},
{
"id": "axicabtagene-ciloleucel",
"kind": "drug",
"name": "Axicabtagene ciloleucel",
"url": "https://onco.cc/drugs/axicabtagene-ciloleucel/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11147646/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11147646/v1",
"title": "Early Prediction of Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma Using a Three-Gene Classifier",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched BIRC5 and HNRNPA2B1.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11147646/v1",
"records": [
{
"id": "birc5",
"kind": "target",
"name": "BIRC5",
"url": "https://onco.cc/targets/birc5/"
},
{
"id": "hnrnpa2b1",
"kind": "target",
"name": "HNRNPA2B1",
"url": "https://onco.cc/targets/hnrnpa2b1/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11097790/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11097790/v1",
"title": "Early-Onset Rectal Adenocarcinoma as the Initial Manifestation of Li- Fraumeni Syndrome Associated with a Germline TP53 p.R337H Variant: A Case Report and Literature Review",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Whole-exome & whole-genome sequencing, Germline (hereditary) testing and TP53.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11097790/v1",
"records": [
{
"id": "wes-wgs",
"kind": "technology",
"name": "Whole-exome & whole-genome sequencing",
"url": "https://onco.cc/technologies/wes-wgs/"
},
{
"id": "germline-testing",
"kind": "technology",
"name": "Germline (hereditary) testing",
"url": "https://onco.cc/technologies/germline-testing/"
},
{
"id": "tp53",
"kind": "target",
"name": "TP53",
"url": "https://onco.cc/targets/tp53/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11097744/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11097744/v1",
"title": "EGFR tyrosine kinase inhibitor receipt and overall survival in metastatic non-small cell lung cancer in Egypt A retrospective descriptive cohort study",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Small-molecule kinase inhibitors, EGFR and Erlotinib.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11097744/v1",
"records": [
{
"id": "kinase-inhibitors",
"kind": "technology",
"name": "Small-molecule kinase inhibitors",
"url": "https://onco.cc/technologies/kinase-inhibitors/"
},
{
"id": "egfr",
"kind": "target",
"name": "EGFR",
"url": "https://onco.cc/targets/egfr/"
},
{
"id": "erlotinib",
"kind": "drug",
"name": "Erlotinib",
"url": "https://onco.cc/drugs/erlotinib/"
},
{
"id": "gefitinib",
"kind": "drug",
"name": "Gefitinib",
"url": "https://onco.cc/drugs/gefitinib/"
},
{
"id": "egf",
"kind": "target",
"name": "EGF",
"url": "https://onco.cc/targets/egf/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10655789/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10655789/v1",
"title": "Genome-based benchmarking of 177 different breast cancer polygenic risk scores",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched HER2 and SET.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10655789/v1",
"records": [
{
"id": "her2",
"kind": "target",
"name": "HER2",
"url": "https://onco.cc/targets/her2/"
},
{
"id": "set",
"kind": "target",
"name": "SET",
"url": "https://onco.cc/targets/set/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10970828/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10970828/v1",
"title": "Harmine derivative ACB1801 induces ferroptosis vulnerability and STAT1 pathway activation to sensitize MSS colorectal cancer to anti–PD-1 immunotherapy",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched PD-1, State and STAT1.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10970828/v1",
"records": [
{
"id": "pd1",
"kind": "target",
"name": "PD-1",
"url": "https://onco.cc/targets/pd1/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
},
{
"id": "stat1",
"kind": "target",
"name": "STAT1",
"url": "https://onco.cc/targets/stat1/"
},
{
"id": "cxcl10",
"kind": "target",
"name": "CXCL10",
"url": "https://onco.cc/targets/cxcl10/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11168431/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11168431/v1",
"title": "Hospital financial implications of subcutaneous versus intravenous trastuzumab plus pertuzumab in Japan: a micro-costing and threshold analysis",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Pertuzumab and Trastuzumab.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11168431/v1",
"records": [
{
"id": "pertuzumab",
"kind": "drug",
"name": "Pertuzumab",
"url": "https://onco.cc/drugs/pertuzumab/"
},
{
"id": "trastuzumab",
"kind": "drug",
"name": "Trastuzumab",
"url": "https://onco.cc/drugs/trastuzumab/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10999962/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10999962/v1",
"title": "How to improve cancer outreach programmes in rural areas: insights from a realist evaluation",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Chemoprevention & risk-reducing surgery.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10999962/v1",
"records": [
{
"id": "chemoprevention",
"kind": "technology",
"name": "Chemoprevention & risk-reducing surgery",
"url": "https://onco.cc/technologies/chemoprevention/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.09.758054#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.09.758054",
"title": "Inferring ecDNA Evolution from Allele Frequency Spectra",
"content_text": "Posted on bioRxiv on 11 October 2026; not peer reviewed; matched Whole-exome & whole-genome sequencing.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.09.758054",
"records": [
{
"id": "wes-wgs",
"kind": "technology",
"name": "Whole-exome & whole-genome sequencing",
"url": "https://onco.cc/technologies/wes-wgs/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11298080/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11298080/v1",
"title": "Integrated Single-Cell and Cross-Species Analysis Reveals CMP Vulnerability and SMYD3 as a Novel Epigenetic Biomarker in Acute Myeloid Leukemia",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and EZH2.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11298080/v1",
"records": [
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "ezh2",
"kind": "target",
"name": "EZH2",
"url": "https://onco.cc/targets/ezh2/"
},
{
"id": "nras",
"kind": "target",
"name": "NRAS",
"url": "https://onco.cc/targets/nras/"
},
{
"id": "etv6",
"kind": "target",
"name": "ETV6",
"url": "https://onco.cc/targets/etv6/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.08.26364913#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.08.26364913",
"title": "Integrative Omics Analysis Reveals Functional Variants of Hemoglobin Zeta (HBZ) as an Ancestry-Specific Risk Factor for Triple-Negative Breast Cancer",
"content_text": "Posted on medRxiv on 11 October 2026; not peer reviewed; matched Whole-exome & whole-genome sequencing, CCDC6 and NR4A3.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "medRxiv",
"doi": "10.64898/2026.10.08.26364913",
"records": [
{
"id": "wes-wgs",
"kind": "technology",
"name": "Whole-exome & whole-genome sequencing",
"url": "https://onco.cc/technologies/wes-wgs/"
},
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
},
{
"id": "nr4a3",
"kind": "target",
"name": "NR4A3",
"url": "https://onco.cc/targets/nr4a3/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.08.757715#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.08.757715",
"title": "Linking somatic variants to altered methylation profiles in nanopore-derived breast and pancreatic cancer genomes using unduliner",
"content_text": "Posted on bioRxiv on 11 October 2026; not peer reviewed; matched DNA methylation profiling.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.08.757715",
"records": [
{
"id": "methylation-profiling",
"kind": "technology",
"name": "DNA methylation profiling",
"url": "https://onco.cc/technologies/methylation-profiling/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10822292/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10822292/v1",
"title": "MESNet: A Lightweight Transformer-CNN Collaborative Network with Morphology Awareness for Glioma Segmentation",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched State.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10822292/v1",
"records": [
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.05.756646#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.05.756646",
"title": "Microglia transcriptomic response to doxorubicin-induced genotoxic stress",
"content_text": "Posted on bioRxiv on 11 October 2026; not peer reviewed; matched Doxorubicin.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
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"records": [
{
"id": "doxorubicin",
"kind": "drug",
"name": "Doxorubicin",
"url": "https://onco.cc/drugs/doxorubicin/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11003195/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11003195/v1",
"title": "Patient-derived organoids inform treatment response and clinical outcomes in tumors of uncertain differentiation",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Patient-derived organoids and Immune checkpoint inhibitors.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11003195/v1",
"records": [
{
"id": "organoids",
"kind": "technology",
"name": "Patient-derived organoids",
"url": "https://onco.cc/technologies/organoids/"
},
{
"id": "checkpoint-inhibitor",
"kind": "technology",
"name": "Immune checkpoint inhibitors",
"url": "https://onco.cc/technologies/checkpoint-inhibitor/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10381208/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10381208/v1",
"title": "Plasma exosomal miR-29b promotes the progression of endometrial cancer by activating the Wnt/β-catenin signaling pathway via FOLR1-mediated regulation of CTNNB1",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Liquid biopsy, Folate receptor alpha and CTNNB1.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10381208/v1",
"records": [
{
"id": "liquid-biopsy",
"kind": "technology",
"name": "Liquid biopsy",
"url": "https://onco.cc/technologies/liquid-biopsy/"
},
{
"id": "folr1",
"kind": "target",
"name": "Folate receptor alpha",
"url": "https://onco.cc/targets/folr1/"
},
{
"id": "ctnnb1",
"kind": "target",
"name": "CTNNB1",
"url": "https://onco.cc/targets/ctnnb1/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10943844/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10943844/v1",
"title": "Posterior reversible encephalopathy syndrome during enfortumab vedotin therapy: a case report",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched MRI, Antibody-drug conjugate and Enfortumab vedotin.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10943844/v1",
"records": [
{
"id": "mri",
"kind": "technology",
"name": "MRI",
"url": "https://onco.cc/technologies/mri/"
},
{
"id": "adc",
"kind": "technology",
"name": "Antibody-drug conjugate",
"url": "https://onco.cc/technologies/adc/"
},
{
"id": "enfortumab-vedotin",
"kind": "drug",
"name": "Enfortumab vedotin",
"url": "https://onco.cc/drugs/enfortumab-vedotin/"
},
{
"id": "nivolumab",
"kind": "drug",
"name": "Nivolumab",
"url": "https://onco.cc/drugs/nivolumab/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10946712/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10946712/v1",
"title": "Primary Leiomyosarcoma of the Urinary Bladder in a Middle-Aged Woman: A Case Report with Review of Previously Published Cases",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched MYOD1 and SOX10.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10946712/v1",
"records": [
{
"id": "myod1",
"kind": "target",
"name": "MYOD1",
"url": "https://onco.cc/targets/myod1/"
},
{
"id": "sox10",
"kind": "target",
"name": "SOX10",
"url": "https://onco.cc/targets/sox10/"
}
]
}
},
{
"id": "https://doi.org/10.31234/osf.io/jktdh_v1#onco-edge-preprint",
"url": "https://doi.org/10.31234/osf.io/jktdh_v1",
"title": "Psilocybin-Assisted Therapy for Existential Distress in Serious and Life-Limiting Illness: Emerging Trial Evidence, Barriers to Access, and the Case for Individualized Eligibility",
"content_text": "Posted on PsyArXiv on 11 October 2026; not peer reviewed; matched State.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "PsyArXiv",
"doi": "10.31234/osf.io/jktdh_v1",
"records": [
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11073099/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11073099/v1",
"title": "QSOX1 Promotes Migration and Invasion in Epithelial Ovarian Cancer Cells with Functional Involvement of CLDN1",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched RNA sequencing & expression profiling.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11073099/v1",
"records": [
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10942986/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10942986/v1",
"title": "Radiation-Induced High-Grade Glioma in a Long-Term Survivor of Medulloblastoma: A Case Report",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched MRI, IDH1 / IDH2 and Ki-67.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10942986/v1",
"records": [
{
"id": "mri",
"kind": "technology",
"name": "MRI",
"url": "https://onco.cc/technologies/mri/"
},
{
"id": "idh",
"kind": "target",
"name": "IDH1 / IDH2",
"url": "https://onco.cc/targets/idh/"
},
{
"id": "mki67",
"kind": "target",
"name": "Ki-67",
"url": "https://onco.cc/targets/mki67/"
},
{
"id": "atrx",
"kind": "target",
"name": "ATRX",
"url": "https://onco.cc/targets/atrx/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10977773/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10977773/v1",
"title": "Salivary microbiome exhibits stage-associated network topological shifts in upper gastrointestinal carcinogenesis",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Azacitidine, Decitabine + cedazuridine and CLTC.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10977773/v1",
"records": [
{
"id": "azacitidine",
"kind": "drug",
"name": "Azacitidine",
"url": "https://onco.cc/drugs/azacitidine/"
},
{
"id": "decitabine-cedazuridine",
"kind": "drug",
"name": "Decitabine + cedazuridine",
"url": "https://onco.cc/drugs/decitabine-cedazuridine/"
},
{
"id": "cltc",
"kind": "target",
"name": "CLTC",
"url": "https://onco.cc/targets/cltc/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.08.757494#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.08.757494",
"title": "Scalable methylome-transcriptome profiling resolves clonal organization in human hematopoiesis",
"content_text": "Posted on bioRxiv on 11 October 2026; not peer reviewed; matched Single-cell & spatial profiling and State.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.08.757494",
"records": [
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11034854/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11034854/v1",
"title": "Six-Weekly Low-Dose Nivolumab Combined with Oral Triple Metronomic Chemotherapy for Advanced Cancers of the Head and Neck: An Open-Label, Prospective, Single-Institution Experience from Eastern India",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Cisplatin, Azacitidine and Decitabine + cedazuridine.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11034854/v1",
"records": [
{
"id": "cisplatin",
"kind": "drug",
"name": "Cisplatin",
"url": "https://onco.cc/drugs/cisplatin/"
},
{
"id": "azacitidine",
"kind": "drug",
"name": "Azacitidine",
"url": "https://onco.cc/drugs/azacitidine/"
},
{
"id": "decitabine-cedazuridine",
"kind": "drug",
"name": "Decitabine + cedazuridine",
"url": "https://onco.cc/drugs/decitabine-cedazuridine/"
},
{
"id": "cytotoxic-chemotherapy",
"kind": "technology",
"name": "Cytotoxic chemotherapy",
"url": "https://onco.cc/technologies/cytotoxic-chemotherapy/"
},
{
"id": "platinum",
"kind": "technology",
"name": "Platinum agents",
"url": "https://onco.cc/technologies/platinum/"
},
{
"id": "pembrolizumab",
"kind": "drug",
"name": "Pembrolizumab",
"url": "https://onco.cc/drugs/pembrolizumab/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.04.756488#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.04.756488",
"title": "SORT disentangles multilevel gene programs across heterogeneous spatial transcriptomic atlases",
"content_text": "Posted on bioRxiv on 11 October 2026; not peer reviewed; matched Atlas.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.04.756488",
"records": [
{
"id": "atlas-aignostics",
"kind": "technology",
"name": "Atlas",
"url": "https://onco.cc/technologies/atlas-aignostics/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10813538/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10813538/v1",
"title": "Thrombotic Risk of Targeted Therapies in Breast Cancer: A Real-World Cohort Study",
"content_text": "Posted on Research Square on 11 October 2026; not peer reviewed; matched Everolimus, CDK4/6 inhibitors and CDK4/6.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10813538/v1",
"records": [
{
"id": "everolimus",
"kind": "drug",
"name": "Everolimus",
"url": "https://onco.cc/drugs/everolimus/"
},
{
"id": "cdk46-inhibitor",
"kind": "technology",
"name": "CDK4/6 inhibitors",
"url": "https://onco.cc/technologies/cdk46-inhibitor/"
},
{
"id": "cdk4-6",
"kind": "target",
"name": "CDK4/6",
"url": "https://onco.cc/targets/cdk4-6/"
},
{
"id": "parp",
"kind": "target",
"name": "PARP",
"url": "https://onco.cc/targets/parp/"
},
{
"id": "palbociclib",
"kind": "drug",
"name": "Palbociclib",
"url": "https://onco.cc/drugs/palbociclib/"
},
{
"id": "mtor",
"kind": "target",
"name": "mTOR",
"url": "https://onco.cc/targets/mtor/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.04.756474#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.04.756474",
"title": "Tissue retention of dendritic cells drives age-associated protective tolerogenic lymphoid structures",
"content_text": "Posted on bioRxiv on 11 October 2026; not peer reviewed; matched State.",
"date_published": "2026-10-11T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-11",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.04.756474",
"records": [
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.02.756019#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.02.756019",
"title": "Point-Process Modelling of Cell-Type Interaction Structure in CosMx Glioma Data for Hypothesis-Driven Tumor Inference from scRNA-seq",
"content_text": "Posted on bioRxiv on 10 October 2026; not peer reviewed; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and Nicheformer.",
"date_published": "2026-10-10T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-10",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.02.756019",
"records": [
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "nicheformer",
"kind": "technology",
"name": "Nicheformer",
"url": "https://onco.cc/technologies/nicheformer/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.09.757903#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.09.757903",
"title": "Repurposing clofarabine against enteric pathogens via metabolic starvation",
"content_text": "Posted on bioRxiv on 10 October 2026; not peer reviewed; matched Clofarabine.",
"date_published": "2026-10-10T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-10",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.09.757903",
"records": [
{
"id": "clofarabine",
"kind": "drug",
"name": "Clofarabine",
"url": "https://onco.cc/drugs/clofarabine/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.02.756334#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.02.756334",
"title": "Restoration of deficient IL-15 signaling enhances innate lymphoid cell immunity in brain metastasis",
"content_text": "Posted on bioRxiv on 10 October 2026; not peer reviewed; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and TNFRSF10B.",
"date_published": "2026-10-10T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-10",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.02.756334",
"records": [
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "tnfrsf10b",
"kind": "target",
"name": "TNFRSF10B",
"url": "https://onco.cc/targets/tnfrsf10b/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.urolonc.2026.09.003#onco-edge-paper",
"url": "https://doi.org/10.1016/j.urolonc.2026.09.003",
"title": "Comparing NCCN-based risk groups to the PROTEUS definition of high-risk localized prostate cancer to inform peri-operative care.",
"content_text": "Published in Urol Oncol on 3 October 2026; found by the roadmap watch for A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy.",
"date_published": "2026-10-03T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-03",
"precision": "day",
"venue": "Urol Oncol",
"doi": "10.1016/j.urolonc.2026.09.003",
"records": [
{
"id": "nct03767244",
"kind": "trial",
"name": "A Study of Apalutamide in Participants With High-Risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy",
"url": "https://onco.cc/trials/nct03767244/"
},
{
"id": "prostate-roadmap",
"kind": "roadmap",
"name": "Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch",
"url": "https://onco.cc/roadmaps/prostate-roadmap/"
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]
}
},
{
"id": "https://doi.org/10.1007/s10014-026-00551-5#onco-edge-paper",
"url": "https://doi.org/10.1007/s10014-026-00551-5",
"title": "Germinoma in late adulthood with extensive dissemination: a case report and literature review.",
"content_text": "Published on 3 October 2026 after first appearing as a preprint; matched MRI, DNA methylation profiling and Platinum agents.",
"date_published": "2026-10-03T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-03",
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"doi": "10.1007/s10014-026-00551-5",
"records": [
{
"id": "mri",
"kind": "technology",
"name": "MRI",
"url": "https://onco.cc/technologies/mri/"
},
{
"id": "methylation-profiling",
"kind": "technology",
"name": "DNA methylation profiling",
"url": "https://onco.cc/technologies/methylation-profiling/"
},
{
"id": "platinum",
"kind": "technology",
"name": "Platinum agents",
"url": "https://onco.cc/technologies/platinum/"
},
{
"id": "carboplatin",
"kind": "drug",
"name": "Carboplatin",
"url": "https://onco.cc/drugs/carboplatin/"
},
{
"id": "etoposide",
"kind": "drug",
"name": "Etoposide",
"url": "https://onco.cc/drugs/etoposide/"
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]
}
},
{
"id": "https://doi.org/10.1093/ijpp/riag140#onco-edge-paper",
"url": "https://doi.org/10.1093/ijpp/riag140",
"title": "How community pharmacies can raise uterine cancer awareness among women from ethnic minority populations.",
"content_text": "Published on 3 October 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-10-03T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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"doi": "10.1093/ijpp/riag140",
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"id": "ccdc6",
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}
},
{
"id": "https://doi.org/10.1007/s10147-026-03202-z#onco-edge-paper",
"url": "https://doi.org/10.1007/s10147-026-03202-z",
"title": "Serum albumin is associated with immune-related hypothyroidism and treatment continuity in non-small cell lung cancer.",
"content_text": "Published on 3 October 2026 after first appearing as a preprint; matched Nintedanib, Immune checkpoint inhibitors and CCDC6.",
"date_published": "2026-10-03T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-03",
"precision": "day",
"doi": "10.1007/s10147-026-03202-z",
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{
"id": "nintedanib",
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"name": "Nintedanib",
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},
{
"id": "checkpoint-inhibitor",
"kind": "technology",
"name": "Immune checkpoint inhibitors",
"url": "https://onco.cc/technologies/checkpoint-inhibitor/"
},
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s11538-026-01703-6#onco-edge-paper",
"url": "https://doi.org/10.1007/s11538-026-01703-6",
"title": "Stacked Waves and Qualitative Analysis of an Oncolytic Virus-Immune Model.",
"content_text": "Published on 3 October 2026 after first appearing as a preprint; matched Oncolytic viruses and Mathematical models of cancer.",
"date_published": "2026-10-03T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-03",
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{
"id": "oncolytic-virus",
"kind": "technology",
"name": "Oncolytic viruses",
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},
{
"id": "mathematical-oncology",
"kind": "technology",
"name": "Mathematical models of cancer",
"url": "https://onco.cc/technologies/mathematical-oncology/"
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]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10893690/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10893690/v1",
"title": "A generalized similarity metric based on Sobolev space geometry for deformable image registration in image-guided radiotherapy",
"content_text": "Posted on Research Square on 9 October 2026; not peer reviewed; matched IMRT / IGRT, MR-guided adaptive radiotherapy and Adaptive radiotherapy.",
"date_published": "2026-10-09T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-09",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10893690/v1",
"records": [
{
"id": "imrt-igrt",
"kind": "technology",
"name": "IMRT / IGRT",
"url": "https://onco.cc/technologies/imrt-igrt/"
},
{
"id": "mr-linac",
"kind": "technology",
"name": "MR-guided adaptive radiotherapy",
"url": "https://onco.cc/technologies/mr-linac/"
},
{
"id": "adaptive-radiotherapy",
"kind": "technology",
"name": "Adaptive radiotherapy",
"url": "https://onco.cc/technologies/adaptive-radiotherapy/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-11068490/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-11068490/v1",
"title": "A novel HDAC6/HIF-1α dual inhibitor halts malignant progression and reprograms immune microenvironment in triple-negative breast cancer",
"content_text": "Posted on Research Square on 9 October 2026; not peer reviewed; matched Sorafenib, Anti-angiogenic therapy and Panobinostat.",
"date_published": "2026-10-09T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-09",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-11068490/v1",
"records": [
{
"id": "sorafenib",
"kind": "drug",
"name": "Sorafenib",
"url": "https://onco.cc/drugs/sorafenib/"
},
{
"id": "antiangiogenic",
"kind": "technology",
"name": "Anti-angiogenic therapy",
"url": "https://onco.cc/technologies/antiangiogenic/"
},
{
"id": "panobinostat",
"kind": "drug",
"name": "Panobinostat",
"url": "https://onco.cc/drugs/panobinostat/"
},
{
"id": "hdac",
"kind": "target",
"name": "Histone deacetylases",
"url": "https://onco.cc/targets/hdac/"
},
{
"id": "hif1a",
"kind": "target",
"name": "HIF-1α",
"url": "https://onco.cc/targets/hif1a/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.07.26364961#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.07.26364961",
"title": "A spatial AI-based biomarker with independent prognostic value in early low- and intermediate- risk breast cancer",
"content_text": "Posted on medRxiv on 9 October 2026; not peer reviewed; matched HER2, CCDC6 and SET.",
"date_published": "2026-10-09T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-09",
"precision": "day",
"venue": "medRxiv",
"doi": "10.64898/2026.10.07.26364961",
"records": [
{
"id": "her2",
"kind": "target",
"name": "HER2",
"url": "https://onco.cc/targets/her2/"
},
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
},
{
"id": "set",
"kind": "target",
"name": "SET",
"url": "https://onco.cc/targets/set/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.07.757377#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.07.757377",
"title": "An Immunocompetent Mouse Model of Degarelix Induced Chemical Castration to Investigate Acquired Resistance to Androgen Deprivation.",
"content_text": "Posted on bioRxiv on 9 October 2026; not peer reviewed; matched Degarelix and ELL.",
"date_published": "2026-10-09T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-09",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.07.757377",
"records": [
{
"id": "degarelix",
"kind": "drug",
"name": "Degarelix",
"url": "https://onco.cc/drugs/degarelix/"
},
{
"id": "ell",
"kind": "target",
"name": "ELL",
"url": "https://onco.cc/targets/ell/"
}
]
}
},
{
"id": "https://doi.org/10.64898/2026.10.07.757367#onco-edge-preprint",
"url": "https://doi.org/10.64898/2026.10.07.757367",
"title": "Artificial Intelligence Applied to Epigenomic Data in Leukemia: A Systematic Review of Diagnostic, Prognostic and Monitoring Models",
"content_text": "Posted on bioRxiv on 9 October 2026; not peer reviewed; matched DNA methylation profiling and CCDC6.",
"date_published": "2026-10-09T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-09",
"precision": "day",
"venue": "bioRxiv",
"doi": "10.64898/2026.10.07.757367",
"records": [
{
"id": "methylation-profiling",
"kind": "technology",
"name": "DNA methylation profiling",
"url": "https://onco.cc/technologies/methylation-profiling/"
},
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
}
]
}
},
{
"id": "https://doi.org/10.21203/rs.3.rs-10305486/v1#onco-edge-preprint",
"url": "https://doi.org/10.21203/rs.3.rs-10305486/v1",
"title": "Auditable Federated Learning for Multimodal Brain Tumor Classification under Label Skew and Client Dropout",
"content_text": "Posted on Research Square on 9 October 2026; not peer reviewed; matched MRI and SET.",
"date_published": "2026-10-09T00:00:00Z",
"tags": [
"preprint"
],
"_onco": {
"kind": "preprint",
"date": "2026-10-09",
"precision": "day",
"venue": "Research Square",
"doi": "10.21203/rs.3.rs-10305486/v1",
"records": [
{
"id": "mri",
"kind": "technology",
"name": "MRI",
"url": "https://onco.cc/technologies/mri/"
},
{
"id": "set",
"kind": "target",
"name": "SET",
"url": "https://onco.cc/targets/set/"
}
]
}
},
{
"id": "https://doi.org/10.1186/s40798-026-01115-9#onco-edge-paper",
"url": "https://doi.org/10.1186/s40798-026-01115-9",
"title": "Frequency and Prognostic Significance of T-wave Inversions in Athletes: A Systematic Review and Meta-analysis.",
"content_text": "Published on 2 October 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-10-02T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-02",
"precision": "day",
"doi": "10.1186/s40798-026-01115-9",
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{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
}
]
}
},
{
"id": "https://doi.org/10.1126/sciadv.aej5440#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aej5440",
"title": "Once yearly cell-based therapy for sustained and dose-tunable delivery of monoclonal antibodies.",
"content_text": "Published on 2 October 2026 after first appearing as a preprint; matched Pertuzumab, RNA sequencing & expression profiling and Single-cell & spatial profiling.",
"date_published": "2026-10-02T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-02",
"precision": "day",
"doi": "10.1126/sciadv.aej5440",
"records": [
{
"id": "pertuzumab",
"kind": "drug",
"name": "Pertuzumab",
"url": "https://onco.cc/drugs/pertuzumab/"
},
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "pembrolizumab",
"kind": "drug",
"name": "Pembrolizumab",
"url": "https://onco.cc/drugs/pembrolizumab/"
},
{
"id": "ipilimumab",
"kind": "drug",
"name": "Ipilimumab",
"url": "https://onco.cc/drugs/ipilimumab/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s00520-026-11255-z#onco-edge-paper",
"url": "https://doi.org/10.1007/s00520-026-11255-z",
"title": "Patient preferences for treatment‑free intervals in multiple myeloma: mixed‑methods insights on monitoring trade‑offs and supportive care improvements.",
"content_text": "Published on 2 October 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-10-02T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-02",
"precision": "day",
"doi": "10.1007/s00520-026-11255-z",
"records": [
{
"id": "ccdc6",
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"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
}
]
}
},
{
"id": "https://doi.org/10.1126/sciadv.aeg3462#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aeg3462",
"title": "The landscape of allele-specific expression in human kidneys.",
"content_text": "Published on 2 October 2026 after first appearing as a preprint; matched Whole-exome & whole-genome sequencing and RNA sequencing & expression profiling.",
"date_published": "2026-10-02T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-02",
"precision": "day",
"doi": "10.1126/sciadv.aeg3462",
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{
"id": "wes-wgs",
"kind": "technology",
"name": "Whole-exome & whole-genome sequencing",
"url": "https://onco.cc/technologies/wes-wgs/"
},
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
}
]
}
},
{
"id": "https://doi.org/10.1126/sciadv.aeh8973#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aeh8973",
"title": "Tumor cell-intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer.",
"content_text": "Published on 2 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling, CAR-T cell therapy and State.",
"date_published": "2026-10-02T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-02",
"precision": "day",
"doi": "10.1126/sciadv.aeh8973",
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{
"id": "single-cell-spatial",
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"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "car-t",
"kind": "technology",
"name": "CAR-T cell therapy",
"url": "https://onco.cc/technologies/car-t/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
},
{
"id": "nfe2l2",
"kind": "target",
"name": "NFE2L2",
"url": "https://onco.cc/targets/nfe2l2/"
},
{
"id": "keap1",
"kind": "target",
"name": "KEAP1",
"url": "https://onco.cc/targets/keap1/"
}
]
}
},
{
"id": "https://doi.org/10.1200/jco-26-02343#onco-edge-paper",
"url": "https://doi.org/10.1200/jco-26-02343",
"title": "Erratum: Five-Year Outcomes of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy for Locally Advanced Rectal Cancer: Updated Results of the STELLAR Trial.",
"content_text": "Published in J Clin Oncol on 25 September 2026; found by the roadmap watch for STELLAR.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-25",
"precision": "day",
"venue": "J Clin Oncol",
"doi": "10.1200/jco-26-02343",
"records": [
{
"id": "stellar",
"kind": "trial",
"name": "STELLAR",
"url": "https://onco.cc/trials/stellar/"
},
{
"id": "devices-roadmap",
"kind": "roadmap",
"name": "Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants",
"url": "https://onco.cc/roadmaps/devices-roadmap/"
}
]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-imlunestrant-combination-abemaciclib-er-positive-her2-negative-esr1-mutated-advanced-or#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-imlunestrant-combination-abemaciclib-er-positive-her2-negative-esr1-mutated-advanced-or",
"title": "FDA approves imlunestrant in combination with abemaciclib for ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer",
"content_text": "On September 18, 2026, the Food and Drug Administration approved imlunestrant (Inluriyo) in combination with abemaciclib (Verzenio), for adults with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, estrogen receptor 1 (ESR1)-mutated advanced or metastatic breast cancer, as detected by an FDA-authorized test, with disease progression following at least one line of endocrine therapy.",
"date_published": "2026-09-18T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-09-18",
"precision": "day",
"venue": "FDA",
"records": [
{
"id": "imlunestrant",
"kind": "drug",
"name": "Imlunestrant",
"url": "https://onco.cc/drugs/imlunestrant/"
},
{
"id": "abemaciclib",
"kind": "drug",
"name": "Abemaciclib",
"url": "https://onco.cc/drugs/abemaciclib/"
},
{
"id": "breast-hr-positive",
"kind": "cancer",
"name": "HR-positive / HER2-negative breast cancer",
"url": "https://onco.cc/cancers/breast-hr-positive/"
},
{
"id": "breast-cancer",
"kind": "cancer",
"name": "Breast cancer",
"url": "https://onco.cc/cancers/breast-cancer/"
},
{
"id": "hr-positive-early-high-risk",
"kind": "cancer",
"name": "High-risk early HR-positive breast cancer",
"url": "https://onco.cc/cancers/hr-positive-early-high-risk/"
},
{
"id": "hr-positive-metastatic-post-cdk46",
"kind": "cancer",
"name": "HR-positive metastatic breast cancer after CDK4/6 inhibitors",
"url": "https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/"
},
{
"id": "cdk4-6",
"kind": "target",
"name": "CDK4/6",
"url": "https://onco.cc/targets/cdk4-6/"
},
{
"id": "estrogen-receptor",
"kind": "target",
"name": "Estrogen receptor",
"url": "https://onco.cc/targets/estrogen-receptor/"
}
]
}
},
{
"id": "https://doi.org/10.3760/cma.j.cn511374-20260423-00188#onco-edge-paper",
"url": "https://doi.org/10.3760/cma.j.cn511374-20260423-00188",
"title": "[Clues for identifying Diamond-Blackfan anemia among infants with early severe anemia: Clinical and genetic analysis of 11 cases].",
"content_text": "Published in Zhonghua Yi Xue Yi Chuan Xue Za Zhi on 1 October 2026; matched the OnCo record for RPS19.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi",
"doi": "10.3760/cma.j.cn511374-20260423-00188",
"records": [
{
"id": "rps19",
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"name": "RPS19",
"url": "https://onco.cc/targets/rps19/"
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{
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"name": "RPS29",
"url": "https://onco.cc/targets/rps29/"
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]
}
},
{
"id": "https://doi.org/10.1111/acel.70737#onco-edge-paper",
"url": "https://doi.org/10.1111/acel.70737",
"title": "A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1111/acel.70737",
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{
"id": "proteomics",
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"name": "Proteomics & phosphoproteomics",
"url": "https://onco.cc/technologies/proteomics/"
}
]
}
},
{
"id": "https://doi.org/10.1093/toxsci/kfag122#onco-edge-paper",
"url": "https://doi.org/10.1093/toxsci/kfag122",
"title": "A high-throughput method to computationally develop candidate adverse outcome pathways in humans: a proof of concept with insecticides and Parkinson's Disease.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Atlas, PTEN and MAPK1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1093/toxsci/kfag122",
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{
"id": "atlas-aignostics",
"kind": "technology",
"name": "Atlas",
"url": "https://onco.cc/technologies/atlas-aignostics/"
},
{
"id": "pten",
"kind": "target",
"name": "PTEN",
"url": "https://onco.cc/targets/pten/"
},
{
"id": "mapk1",
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"name": "MAPK1",
"url": "https://onco.cc/targets/mapk1/"
}
]
}
},
{
"id": "https://doi.org/10.1016/s2352-4642(26)00163-x#onco-edge-paper",
"url": "https://doi.org/10.1016/s2352-4642(26)00163-x",
"title": "Adolescent health across Asia Pacific, 2000-23: a systematic analysis for the Global Burden of Disease Study 2023.",
"content_text": "Published in Lancet Child Adolesc Health on 1 October 2026; matched the OnCo record for Logic-gated therapeutics.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Lancet Child Adolesc Health",
"doi": "10.1016/s2352-4642(26)00163-x",
"records": [
{
"id": "logic-gated-therapeutics",
"kind": "technology",
"name": "Logic-gated therapeutics",
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]
}
},
{
"id": "https://doi.org/10.5414/cn111966#onco-edge-paper",
"url": "https://doi.org/10.5414/cn111966",
"title": "Analysis of end-stage renal disease mediated by cuproptosis-related genes.",
"content_text": "Published in Clin Nephrol on 1 October 2026; matched the OnCo record for ATP7B.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Clin Nephrol",
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"records": [
{
"id": "atp7b",
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"url": "https://onco.cc/targets/atp7b/"
},
{
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"url": "https://onco.cc/targets/dlst/"
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]
}
},
{
"id": "https://doi.org/10.1530/etj-26-0100#onco-edge-paper",
"url": "https://doi.org/10.1530/etj-26-0100",
"title": "Approaches to thyroid nodules in paediatric cancer predisposition syndromes.",
"content_text": "Published in Eur Thyroid J on 1 October 2026; matched the OnCo record for DICER1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Eur Thyroid J",
"doi": "10.1530/etj-26-0100",
"records": [
{
"id": "dicer1",
"kind": "target",
"name": "DICER1",
"url": "https://onco.cc/targets/dicer1/"
}
]
}
},
{
"id": "https://doi.org/10.1245/s10434-026-20276-1#onco-edge-paper",
"url": "https://doi.org/10.1245/s10434-026-20276-1",
"title": "ASO Visual Abstract: A Prospective Multicenter Comparative Cohort Study of Neoadjuvant Sintilimab Plus Chemotherapy and Chemoradiotherapy in Resectable Clinical Node-Positive Esophageal Squamous Cell Carcinoma.",
"content_text": "Published in Ann Surg Oncol on 1 October 2026; matched the OnCo record for Sintilimab.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Ann Surg Oncol",
"doi": "10.1245/s10434-026-20276-1",
"records": [
{
"id": "sintilimab",
"kind": "drug",
"name": "Sintilimab",
"url": "https://onco.cc/drugs/sintilimab/"
}
]
}
},
{
"id": "https://doi.org/10.1245/s10434-026-20326-8#onco-edge-paper",
"url": "https://doi.org/10.1245/s10434-026-20326-8",
"title": "ASO Visual Abstract: Mex3a Stabilizes INHBB mRNA to Activate SMAD-Signaling and Promote Hepatocellular Carcinoma Metastasis.",
"content_text": "Published in Ann Surg Oncol on 1 October 2026; matched the OnCo record for INHBB.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Ann Surg Oncol",
"doi": "10.1245/s10434-026-20326-8",
"records": [
{
"id": "inhbb",
"kind": "target",
"name": "INHBB",
"url": "https://onco.cc/targets/inhbb/"
}
]
}
},
{
"id": "https://doi.org/10.1245/s10434-026-20304-0#onco-edge-paper",
"url": "https://doi.org/10.1245/s10434-026-20304-0",
"title": "ASO Visual Abstract: Prognostic Value of Intratumoral Expression of Claudin 18.2 in Resected Pancreatic Cancer.",
"content_text": "Published in Ann Surg Oncol on 1 October 2026; matched the OnCo record for Claudin 18.2.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Ann Surg Oncol",
"doi": "10.1245/s10434-026-20304-0",
"records": [
{
"id": "cldn18-2",
"kind": "target",
"name": "Claudin 18.2",
"url": "https://onco.cc/targets/cldn18-2/"
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]
}
},
{
"id": "https://doi.org/10.1245/s10434-026-20303-1#onco-edge-paper",
"url": "https://doi.org/10.1245/s10434-026-20303-1",
"title": "ASO Visual Abstract: Treatment for Oligo-recurrence of Diffuse Pleural Mesothelioma After Extended Pleurectomy/Decortication.",
"content_text": "Published in Ann Surg Oncol on 1 October 2026; matched the OnCo record for Pleural mesothelioma.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Ann Surg Oncol",
"doi": "10.1245/s10434-026-20303-1",
"records": [
{
"id": "pleural-mesothelioma",
"kind": "cancer",
"name": "Pleural mesothelioma",
"url": "https://onco.cc/cancers/pleural-mesothelioma/"
}
]
}
},
{
"id": "https://doi.org/10.1002/pri.70314#onco-edge-paper",
"url": "https://doi.org/10.1002/pri.70314",
"title": "Association Between Danish Guideline Treatments for Breast Cancer and Physiotherapy-Relevant Late Effects: A Nationwide Cohort Study.",
"content_text": "Published in Physiother Res Int on 1 October 2026; matched the OnCo record for Sentinel lymph node biopsy.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Physiother Res Int",
"doi": "10.1002/pri.70314",
"records": [
{
"id": "sentinel-node",
"kind": "technology",
"name": "Sentinel lymph node biopsy",
"url": "https://onco.cc/technologies/sentinel-node/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41409-026-03032-7#onco-edge-paper",
"url": "https://doi.org/10.1038/s41409-026-03032-7",
"title": "ATG exposure in T replete transplant for hematological malignancies: Real world analysis from BMT CTN 1202.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Rebuilding the immune system after treatment and Chronic graft-versus-host disease.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1038/s41409-026-03032-7",
"records": [
{
"id": "rejuv-frontier-immune-reconstitution",
"kind": "technology",
"name": "Rebuilding the immune system after treatment",
"url": "https://onco.cc/technologies/rejuv-frontier-immune-reconstitution/"
},
{
"id": "gvhd-chronic-overview",
"kind": "technology",
"name": "Chronic graft-versus-host disease",
"url": "https://onco.cc/technologies/gvhd-chronic-overview/"
}
]
}
},
{
"id": "https://doi.org/10.1111/apha.70307#onco-edge-paper",
"url": "https://doi.org/10.1111/apha.70307",
"title": "ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes.",
"content_text": "Published in Acta Physiol (Oxf) on 1 October 2026; matched the OnCo record for MPEG1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Acta Physiol (Oxf)",
"doi": "10.1111/apha.70307",
"records": [
{
"id": "mpeg1",
"kind": "target",
"name": "MPEG1",
"url": "https://onco.cc/targets/mpeg1/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41405-026-00486-1#onco-edge-paper",
"url": "https://doi.org/10.1038/s41405-026-00486-1",
"title": "Biological effects of N-acetylcysteine, calcium hydroxide, chlorhexidine and their combinations as intracanal medications: cytotoxicity, genotoxicity and cytokine modulation.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched CCDC6 and Interleukin-10.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1038/s41405-026-00486-1",
"records": [
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
},
{
"id": "il10",
"kind": "target",
"name": "Interleukin-10",
"url": "https://onco.cc/targets/il10/"
}
]
}
},
{
"id": "https://doi.org/10.5414/cp205012#onco-edge-paper",
"url": "https://doi.org/10.5414/cp205012",
"title": "Blinatumomab-induced catastrophic immune effector cell-associated neurotoxicity with diffuse cerebral edema in a patient with ALL: Case report.",
"content_text": "Published in Int J Clin Pharmacol Ther on 1 October 2026; matched the OnCo record for AFF1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Int J Clin Pharmacol Ther",
"doi": "10.5414/cp205012",
"records": [
{
"id": "aff1",
"kind": "target",
"name": "AFF1",
"url": "https://onco.cc/targets/aff1/"
},
{
"id": "blinatumomab",
"kind": "drug",
"name": "Blinatumomab",
"url": "https://onco.cc/drugs/blinatumomab/"
}
]
}
},
{
"id": "https://doi.org/10.1111/liv.70887#onco-edge-paper",
"url": "https://doi.org/10.1111/liv.70887",
"title": "Cell Type-Specific Roles of TBK1 in Steatotic Liver Disease: Evidence for an Inflammatory TBK1<sup>+</sup>CASP1<sup>+</sup> Kupffer Cell State.",
"content_text": "Published in Liver Int on 1 October 2026; matched the OnCo record for TBK1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Liver Int",
"doi": "10.1111/liv.70887",
"records": [
{
"id": "tbk1",
"kind": "target",
"name": "TBK1",
"url": "https://onco.cc/targets/tbk1/"
}
]
}
},
{
"id": "https://doi.org/10.1101/gr.281433.125#onco-edge-paper",
"url": "https://doi.org/10.1101/gr.281433.125",
"title": "Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and Spatial transcriptomics.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1101/gr.281433.125",
"records": [
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "spatial-transcriptomics",
"kind": "technology",
"name": "Spatial transcriptomics",
"url": "https://onco.cc/technologies/spatial-transcriptomics/"
}
]
}
},
{
"id": "https://doi.org/10.1002/pds.70491#onco-edge-paper",
"url": "https://doi.org/10.1002/pds.70491",
"title": "CodeMergeR: A Shiny-Based Application for Codelist Integration.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1002/pds.70491",
"records": [
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
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]
}
},
{
"id": "https://doi.org/10.1002/acm2.70812#onco-edge-paper",
"url": "https://doi.org/10.1002/acm2.70812",
"title": "Commissioning and end-to-end validation of a combined surface-guided and triggered kV imaging workflow for breath-hold SBRT on a Varian TrueBeam.",
"content_text": "Published in J Appl Clin Med Phys on 1 October 2026; matched the OnCo record for In-room imaging for radiotherapy.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Appl Clin Med Phys",
"doi": "10.1002/acm2.70812",
"records": [
{
"id": "in-room-imaging-systems",
"kind": "technology",
"name": "In-room imaging for radiotherapy",
"url": "https://onco.cc/technologies/in-room-imaging-systems/"
}
]
}
},
{
"id": "https://doi.org/10.1002/pro.70808#onco-edge-paper",
"url": "https://doi.org/10.1002/pro.70808",
"title": "Conformational stability and domain-specific structural features of tumor autoantigens regulate autoantibody epitope propensity.",
"content_text": "Published in Protein Sci on 1 October 2026; matched the OnCo record for CTAG1B.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Protein Sci",
"doi": "10.1002/pro.70808",
"records": [
{
"id": "ctag1b",
"kind": "target",
"name": "CTAG1B",
"url": "https://onco.cc/targets/ctag1b/"
},
{
"id": "wt1",
"kind": "target",
"name": "WT1",
"url": "https://onco.cc/targets/wt1/"
}
]
}
},
{
"id": "https://doi.org/10.1111/liv.70854#onco-edge-paper",
"url": "https://doi.org/10.1111/liv.70854",
"title": "Correction to 'FOLFOX Versus FOLFIRI as Second-Line Chemotherapy in Patients With Advanced Biliary Tract Cancers: A Multicenter, Italian Study'.",
"content_text": "Published in Liver Int on 1 October 2026; matched the OnCo record for FOLFIRI.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Liver Int",
"doi": "10.1111/liv.70854",
"records": [
{
"id": "folfiri",
"kind": "drug",
"name": "FOLFIRI",
"url": "https://onco.cc/drugs/folfiri/"
},
{
"id": "folfox",
"kind": "drug",
"name": "FOLFOX",
"url": "https://onco.cc/drugs/folfox/"
}
]
}
},
{
"id": "https://doi.org/10.1002/prp2.70314#onco-edge-paper",
"url": "https://doi.org/10.1002/prp2.70314",
"title": "Cross-Talk Between Histamine H<sub>2</sub> Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment.",
"content_text": "Published in Pharmacol Res Perspect on 1 October 2026; matched the OnCo record for Cytarabine.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Pharmacol Res Perspect",
"doi": "10.1002/prp2.70314",
"records": [
{
"id": "cytarabine",
"kind": "drug",
"name": "Cytarabine",
"url": "https://onco.cc/drugs/cytarabine/"
}
]
}
},
{
"id": "https://doi.org/10.1002/glia.70207#onco-edge-paper",
"url": "https://doi.org/10.1002/glia.70207",
"title": "CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser-Induced Lesions.",
"content_text": "Published in Glia on 1 October 2026; matched the OnCo record for CX3CL1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Glia",
"doi": "10.1002/glia.70207",
"records": [
{
"id": "cx3cl1",
"kind": "target",
"name": "CX3CL1",
"url": "https://onco.cc/targets/cx3cl1/"
}
]
}
},
{
"id": "https://doi.org/10.1158/2159-8290.cd-25-0734#onco-edge-paper",
"url": "https://doi.org/10.1158/2159-8290.cd-25-0734",
"title": "Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched KRAS.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1158/2159-8290.cd-25-0734",
"records": [
{
"id": "kras",
"kind": "target",
"name": "KRAS",
"url": "https://onco.cc/targets/kras/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.immuni.2026.09.009#onco-edge-paper",
"url": "https://doi.org/10.1016/j.immuni.2026.09.009",
"title": "Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Immune checkpoint inhibitors and PD-1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1016/j.immuni.2026.09.009",
"records": [
{
"id": "checkpoint-inhibitor",
"kind": "technology",
"name": "Immune checkpoint inhibitors",
"url": "https://onco.cc/technologies/checkpoint-inhibitor/"
},
{
"id": "pd1",
"kind": "target",
"name": "PD-1",
"url": "https://onco.cc/targets/pd1/"
}
]
}
},
{
"id": "https://doi.org/10.1186/s12916-026-05194-z#onco-edge-paper",
"url": "https://doi.org/10.1186/s12916-026-05194-z",
"title": "Effectiveness of green health prescribing and nature-based interventions in primary care and community settings for older adults: a systematic review of health, wellbeing and social outcomes.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
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"doi": "10.1186/s12916-026-05194-z",
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{
"id": "ccdc6",
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]
}
},
{
"id": "https://doi.org/10.36721/pjps.2026.39.10.277.1#onco-edge-paper",
"url": "https://doi.org/10.36721/pjps.2026.39.10.277.1",
"title": "Effects of curcumin and nicorandil on nilotinib-induced QT interval prolongation in rats: A telemetry-based study.",
"content_text": "Published in Pak J Pharm Sci on 1 October 2026; matched the OnCo record for Nilotinib.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Pak J Pharm Sci",
"doi": "10.36721/pjps.2026.39.10.277.1",
"records": [
{
"id": "nilotinib",
"kind": "drug",
"name": "Nilotinib",
"url": "https://onco.cc/drugs/nilotinib/"
}
]
}
},
{
"id": "https://doi.org/10.1002/pri.70320#onco-edge-paper",
"url": "https://doi.org/10.1002/pri.70320",
"title": "Effects of Progressive Inspiratory Muscle Training on Lung Volume and Respiratory Strength in Patients With Pre-Dialysis Chronic Kidney Disease.",
"content_text": "Published in Physiother Res Int on 1 October 2026; matched the OnCo record for Inflammatory myofibroblastic tumour.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Physiother Res Int",
"doi": "10.1002/pri.70320",
"records": [
{
"id": "inflammatory-myofibroblastic-tumour",
"kind": "cancer",
"name": "Inflammatory myofibroblastic tumour",
"url": "https://onco.cc/cancers/inflammatory-myofibroblastic-tumour/"
}
]
}
},
{
"id": "https://doi.org/10.1111/neup.70076#onco-edge-paper",
"url": "https://doi.org/10.1111/neup.70076",
"title": "Elevated Expression of Caveolin-1 Reflects a Poor Prognosis in Patients With Primary Central Nervous System Lymphomas.",
"content_text": "Published in Neuropathology on 1 October 2026; matched the OnCo record for Primary CNS lymphoma.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Neuropathology",
"doi": "10.1111/neup.70076",
"records": [
{
"id": "primary-cns-lymphoma",
"kind": "cancer",
"name": "Primary CNS lymphoma",
"url": "https://onco.cc/cancers/primary-cns-lymphoma/"
}
]
}
},
{
"id": "https://doi.org/10.2967/jnumed.126.272362#onco-edge-paper",
"url": "https://doi.org/10.2967/jnumed.126.272362",
"title": "End-to-End PET/CT Interpretation and Quantification with an LLM-Orchestrated AI Agent: A Real-World Pilot Study.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched PET/CT, FDG PET and AI trial matching & clinical decision support.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.2967/jnumed.126.272362",
"records": [
{
"id": "pet-ct",
"kind": "technology",
"name": "PET/CT",
"url": "https://onco.cc/technologies/pet-ct/"
},
{
"id": "fdg-pet",
"kind": "technology",
"name": "FDG PET",
"url": "https://onco.cc/technologies/fdg-pet/"
},
{
"id": "ai-trial-matching",
"kind": "technology",
"name": "AI trial matching & clinical decision support",
"url": "https://onco.cc/technologies/ai-trial-matching/"
},
{
"id": "fludeoxyglucose-f18",
"kind": "drug",
"name": "Fludeoxyglucose F-18",
"url": "https://onco.cc/drugs/fludeoxyglucose-f18/"
}
]
}
},
{
"id": "https://doi.org/10.1002/pro.70799#onco-edge-paper",
"url": "https://doi.org/10.1002/pro.70799",
"title": "Engineering a protein homodimer from a heterodimer: A chimeric DBHS protein.",
"content_text": "Published in Protein Sci on 1 October 2026; matched the OnCo record for PSPC1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Protein Sci",
"doi": "10.1002/pro.70799",
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{
"id": "pspc1",
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"name": "PSPC1",
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{
"id": "sfpq",
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{
"id": "https://doi.org/10.1002/jbt.71112#onco-edge-paper",
"url": "https://doi.org/10.1002/jbt.71112",
"title": "Estradiol Promotes Tumor Progression in ERα-Low Endometrial Cancer via the GPER/SphK1 Pathway.",
"content_text": "Published in J Biochem Mol Toxicol on 1 October 2026; matched the OnCo record for CCNE1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Biochem Mol Toxicol",
"doi": "10.1002/jbt.71112",
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{
"id": "ccne1",
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{
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{
"id": "https://doi.org/10.1002/acm2.70787#onco-edge-paper",
"url": "https://doi.org/10.1002/acm2.70787",
"title": "Evaluation of interfractional shift corrections in Gamma Knife radiosurgery.",
"content_text": "Published in J Appl Clin Med Phys on 1 October 2026; matched the OnCo record for Gamma Knife.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Appl Clin Med Phys",
"doi": "10.1002/acm2.70787",
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{
"id": "gamma-knife",
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"name": "Gamma Knife",
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}
},
{
"id": "https://doi.org/10.1002/cncr.70615#onco-edge-paper",
"url": "https://doi.org/10.1002/cncr.70615",
"title": "External validation of the NADIR model for early prostate-specific antigen response prediction in enzalutamide-treated metastatic hormone-sensitive prostate cancer: An analysis of the ARCHES trial.",
"content_text": "Published in Cancer on 1 October 2026; found by the roadmap watch for ARCHES.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Cancer",
"doi": "10.1002/cncr.70615",
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{
"id": "arches",
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{
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"kind": "roadmap",
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"url": "https://onco.cc/roadmaps/hormonal-therapy-roadmap/"
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},
{
"id": "https://doi.org/10.1186/s12916-026-05195-y#onco-edge-paper",
"url": "https://doi.org/10.1186/s12916-026-05195-y",
"title": "Factors influencing access to green health prescribing in primary care for older adults - a qualitative systematic review.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Med-Gemini and MedLM and CCDC6.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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{
"id": "https://doi.org/10.1002/acm2.70818#onco-edge-paper",
"url": "https://doi.org/10.1002/acm2.70818",
"title": "Feasibility of lattice radiation therapy using a noncoplanar vertex arrangement and dynamic conformal arcs.",
"content_text": "Published in J Appl Clin Med Phys on 1 October 2026; matched the OnCo record for VDR.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Appl Clin Med Phys",
"doi": "10.1002/acm2.70818",
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{
"id": "vdr",
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},
{
"id": "https://doi.org/10.1111/ajo.70176#onco-edge-paper",
"url": "https://doi.org/10.1111/ajo.70176",
"title": "Fertility-Sparing Treatment of Endometrial Cancer: Survey of Australian Practice.",
"content_text": "Published in Aust N Z J Obstet Gynaecol on 1 October 2026; matched the OnCo record for Progestins.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Aust N Z J Obstet Gynaecol",
"doi": "10.1111/ajo.70176",
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{
"id": "megestrol-progestins",
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{
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{
"id": "https://doi.org/10.1016/j.urolonc.2026.04.001#onco-edge-paper",
"url": "https://doi.org/10.1016/j.urolonc.2026.04.001",
"title": "FOCS-24: An integrated oncologic-functional endpoint and its preoperative nomogram after focal therapy for localized prostate cancer.",
"content_text": "Published in Urol Oncol on 1 October 2026; matched the OnCo record for Multiparametric prostate MRI.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Urol Oncol",
"doi": "10.1016/j.urolonc.2026.04.001",
"records": [
{
"id": "mp-mri",
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"name": "Multiparametric prostate MRI",
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}
},
{
"id": "https://doi.org/10.1111/cts.70713#onco-edge-paper",
"url": "https://doi.org/10.1111/cts.70713",
"title": "Fruquintinib: Mechanism of Action, Clinical, and Translational Science.",
"content_text": "Published in Clin Transl Sci on 1 October 2026; matched the OnCo record for Fruquintinib.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Clin Transl Sci",
"doi": "10.1111/cts.70713",
"records": [
{
"id": "fruquintinib",
"kind": "drug",
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},
{
"id": "https://doi.org/10.1093/ajrcmb/aanag024#onco-edge-paper",
"url": "https://doi.org/10.1093/ajrcmb/aanag024",
"title": "Furin inhibition protects against acute lung injury in a mouse model of Pseudomonas aeruginosa infection.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and TNFRSF10B.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1093/ajrcmb/aanag024",
"records": [
{
"id": "rna-seq",
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{
"id": "tnfrsf10b",
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},
{
"id": "https://doi.org/10.1002/rcs.70234#onco-edge-paper",
"url": "https://doi.org/10.1002/rcs.70234",
"title": "Gender-Specific Cancer-Related Survival Analysis of Robotic Versus Laparoscopic Low Anterior Resection for Rectal Adenocarcinoma: A Multicenter Study.",
"content_text": "Published in Int J Med Robot on 1 October 2026; matched the OnCo record for Luminal androgen receptor triple-negative breast cancer.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Int J Med Robot",
"doi": "10.1002/rcs.70234",
"records": [
{
"id": "tnbc-luminal-androgen-receptor",
"kind": "cancer",
"name": "Luminal androgen receptor triple-negative breast cancer",
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}
},
{
"id": "https://doi.org/10.1002/prp2.70324#onco-edge-paper",
"url": "https://doi.org/10.1002/prp2.70324",
"title": "Ginsenosides Rb1 and Rg1 Suppress Lipopolysaccharide-Induced Inflammatory Gene Expression in Microglia and Astrocytes, Unlike Rb2.",
"content_text": "Published in Pharmacol Res Perspect on 1 October 2026; matched the OnCo record for RB1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Pharmacol Res Perspect",
"doi": "10.1002/prp2.70324",
"records": [
{
"id": "rb1",
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"name": "RB1",
"url": "https://onco.cc/targets/rb1/"
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]
}
},
{
"id": "https://doi.org/10.1002/mbo3.70373#onco-edge-paper",
"url": "https://doi.org/10.1002/mbo3.70373",
"title": "Gut Microbiome Diversity, Functional Potential, and Ecological Relevance of Hottentotta tamulus.",
"content_text": "Published in Microbiologyopen on 1 October 2026; matched the OnCo record for MT-CO1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Microbiologyopen",
"doi": "10.1002/mbo3.70373",
"records": [
{
"id": "mt-co1",
"kind": "target",
"name": "MT-CO1",
"url": "https://onco.cc/targets/mt-co1/"
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},
{
"id": "https://doi.org/10.1158/1535-7163.mct-25-1077#onco-edge-paper",
"url": "https://doi.org/10.1158/1535-7163.mct-25-1077",
"title": "HDAC Inhibition Unlocks Tumor Plasticity and Enhances Immunotherapy Response in Myc-Driven Small Cell Lung Cancer.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched PD-1, Histone deacetylases and HDAC4.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1158/1535-7163.mct-25-1077",
"records": [
{
"id": "pd1",
"kind": "target",
"name": "PD-1",
"url": "https://onco.cc/targets/pd1/"
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{
"id": "hdac",
"kind": "target",
"name": "Histone deacetylases",
"url": "https://onco.cc/targets/hdac/"
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{
"id": "hdac4",
"kind": "target",
"name": "HDAC4",
"url": "https://onco.cc/targets/hdac4/"
},
{
"id": "rb1",
"kind": "target",
"name": "RB1",
"url": "https://onco.cc/targets/rb1/"
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{
"id": "myc-gene",
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"name": "MYC",
"url": "https://onco.cc/targets/myc-gene/"
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},
{
"id": "https://doi.org/10.1097/cji.0000000000000614#onco-edge-paper",
"url": "https://doi.org/10.1097/cji.0000000000000614",
"title": "Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: Clinical Presentation and Outcomes in Three Patients.",
"content_text": "Published in J Immunother on 1 October 2026; matched the OnCo record for Tocilizumab.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Immunother",
"doi": "10.1097/cji.0000000000000614",
"records": [
{
"id": "tocilizumab",
"kind": "drug",
"name": "Tocilizumab",
"url": "https://onco.cc/drugs/tocilizumab/"
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]
}
},
{
"id": "https://doi.org/10.1002/cncr.70610#onco-edge-paper",
"url": "https://doi.org/10.1002/cncr.70610",
"title": "Impact of post-chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children's Oncology Group AREN0532, AREN0533, and AREN03B2 studies.",
"content_text": "Published in Cancer on 1 October 2026; matched the OnCo record for Advanced-stage classical Hodgkin lymphoma.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Cancer",
"doi": "10.1002/cncr.70610",
"records": [
{
"id": "advanced-stage-classical-hodgkin-lymphoma",
"kind": "cancer",
"name": "Advanced-stage classical Hodgkin lymphoma",
"url": "https://onco.cc/cancers/advanced-stage-classical-hodgkin-lymphoma/"
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}
},
{
"id": "https://doi.org/10.1111/liv.70846#onco-edge-paper",
"url": "https://doi.org/10.1111/liv.70846",
"title": "Inhibition of Acetylation Activity of p300/CBP Ameliorates Hepatic Steatosis Through Downregulation of ACSL4.",
"content_text": "Published in Liver Int on 1 October 2026; matched the OnCo record for EP300.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Liver Int",
"doi": "10.1111/liv.70846",
"records": [
{
"id": "ep300",
"kind": "target",
"name": "EP300",
"url": "https://onco.cc/targets/ep300/"
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{
"id": "https://doi.org/10.1177/19476035261494285#onco-edge-paper",
"url": "https://doi.org/10.1177/19476035261494285",
"title": "Inhibition of Hexokinase 2 Undermines Cartilage Health and Accelerates Osteoarthritis.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and COL2A1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1177/19476035261494285",
"records": [
{
"id": "rna-seq",
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"name": "RNA sequencing & expression profiling",
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},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
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{
"id": "col2a1",
"kind": "target",
"name": "COL2A1",
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},
{
"id": "https://doi.org/10.1016/j.disamonth.2026.102146#onco-edge-paper",
"url": "https://doi.org/10.1016/j.disamonth.2026.102146",
"title": "Insulin autoimmune syndrome (Hirata Disease): An updated review of epidemiology, pathophysiology, clinical features, diagnosis, and management.",
"content_text": "Published in Dis Mon on 1 October 2026; matched the OnCo record for Pancreatic neuroendocrine tumours.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Dis Mon",
"doi": "10.1016/j.disamonth.2026.102146",
"records": [
{
"id": "pancreatic-net",
"kind": "cancer",
"name": "Pancreatic neuroendocrine tumours",
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},
{
"id": "https://doi.org/10.1002/jcsm.70377#onco-edge-paper",
"url": "https://doi.org/10.1002/jcsm.70377",
"title": "Integrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics.",
"content_text": "Published in J Cachexia Sarcopenia Muscle on 1 October 2026; matched the OnCo record for CT body composition and sarcopenia measurement.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Cachexia Sarcopenia Muscle",
"doi": "10.1002/jcsm.70377",
"records": [
{
"id": "ct-body-composition-sarcopenia",
"kind": "technology",
"name": "CT body composition and sarcopenia measurement",
"url": "https://onco.cc/technologies/ct-body-composition-sarcopenia/"
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},
{
"id": "https://doi.org/10.1042/bsr20260173#onco-edge-paper",
"url": "https://doi.org/10.1042/bsr20260173",
"title": "Integrated omics-driven discovery reveals synphilin-1-mediated anoikis resistance through p53 down-regulation.",
"content_text": "Published in Biosci Rep on 1 October 2026; matched the OnCo record for SNCAIP.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Biosci Rep",
"doi": "10.1042/bsr20260173",
"records": [
{
"id": "sncaip",
"kind": "target",
"name": "SNCAIP",
"url": "https://onco.cc/targets/sncaip/"
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},
{
"id": "https://doi.org/10.1002/psp4.70352#onco-edge-paper",
"url": "https://doi.org/10.1002/psp4.70352",
"title": "Integrating a Tumor Size-Overall Survival Model Into a Spatial Quantitative Systems Pharmacology Framework for Antibody-Drug Conjugates in Non-Small Cell Lung Cancer.",
"content_text": "Published in CPT Pharmacometrics Syst Pharmacol on 1 October 2026; matched the OnCo record for Trastuzumab deruxtecan.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "CPT Pharmacometrics Syst Pharmacol",
"doi": "10.1002/psp4.70352",
"records": [
{
"id": "trastuzumab-deruxtecan",
"kind": "drug",
"name": "Trastuzumab deruxtecan",
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},
{
"id": "https://doi.org/10.1182/bloodadvances.2025019220#onco-edge-paper",
"url": "https://doi.org/10.1182/bloodadvances.2025019220",
"title": "JARID2 inhibition reprograms human hematopoietic progenitor cells to enhance bone marrow transplantation.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched EZH2 and STAT1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1182/bloodadvances.2025019220",
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{
"id": "ezh2",
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"name": "EZH2",
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{
"id": "stat1",
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}
},
{
"id": "https://doi.org/10.1042/bcj20260212#onco-edge-paper",
"url": "https://doi.org/10.1042/bcj20260212",
"title": "KDM2B controls HIF levels and activity through its JmjC and CxxC domains.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched HIF-1α.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1042/bcj20260212",
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{
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},
{
"id": "https://doi.org/10.1111/bcpt.70296#onco-edge-paper",
"url": "https://doi.org/10.1111/bcpt.70296",
"title": "Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia-Associated Kidney Injury.",
"content_text": "Published in Basic Clin Pharmacol Toxicol on 1 October 2026; matched the OnCo record for FOXO1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Basic Clin Pharmacol Toxicol",
"doi": "10.1111/bcpt.70296",
"records": [
{
"id": "foxo1",
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},
{
"id": "https://doi.org/10.1016/j.cps.2026.05.006#onco-edge-paper",
"url": "https://doi.org/10.1016/j.cps.2026.05.006",
"title": "Management of Hemangiomas.",
"content_text": "Published in Clin Plast Surg on 1 October 2026; matched the OnCo record for Propranolol.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Clin Plast Surg",
"doi": "10.1016/j.cps.2026.05.006",
"records": [
{
"id": "propranolol-hemangeol",
"kind": "drug",
"name": "Propranolol",
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]
}
},
{
"id": "https://doi.org/10.1002/age.70185#onco-edge-paper",
"url": "https://doi.org/10.1002/age.70185",
"title": "MiR-376c-3p Targets STRBP mRNA to Regulate Cashmere Goat Hair Follicle Stem Cell Proliferation and Multipotency by Inhibiting the Wnt/β-Catenin and BMP Signaling Pathways.",
"content_text": "Published in Anim Genet on 1 October 2026; matched the OnCo record for SOX9.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Anim Genet",
"doi": "10.1002/age.70185",
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{
"id": "sox9",
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},
{
"id": "https://doi.org/10.1093/procel/pwag025#onco-edge-paper",
"url": "https://doi.org/10.1093/procel/pwag025",
"title": "Molecular basis of high-torque transmission of the Vibrio polar flagellar motor.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched LPA.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
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"doi": "10.1093/procel/pwag025",
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{
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},
{
"id": "https://doi.org/10.1111/acel.70747#onco-edge-paper",
"url": "https://doi.org/10.1111/acel.70747",
"title": "Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics, Epigenetic age after cancer treatment and Telomere length after treatment.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
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"doi": "10.1111/acel.70747",
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{
"id": "proteomics",
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"name": "Proteomics & phosphoproteomics",
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},
{
"id": "rejuv-age-epigenetic-clocks",
"kind": "technology",
"name": "Epigenetic age after cancer treatment",
"url": "https://onco.cc/technologies/rejuv-age-epigenetic-clocks/"
},
{
"id": "rejuv-age-telomere-length",
"kind": "technology",
"name": "Telomere length after treatment",
"url": "https://onco.cc/technologies/rejuv-age-telomere-length/"
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{
"id": "timp1",
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},
{
"id": "https://doi.org/10.1111/nan.70098#onco-edge-paper",
"url": "https://doi.org/10.1111/nan.70098",
"title": "New Observations on a Low-Grade Diffusely Infiltrative Tumour, SMARCB1 Mutant, Arguing for a New Tumour Type.",
"content_text": "Published in Neuropathol Appl Neurobiol on 1 October 2026; matched the OnCo record for SMARCB1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Neuropathol Appl Neurobiol",
"doi": "10.1111/nan.70098",
"records": [
{
"id": "smarcb1",
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"name": "SMARCB1",
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},
{
"id": "https://doi.org/10.1111/neup.70079#onco-edge-paper",
"url": "https://doi.org/10.1111/neup.70079",
"title": "Non-Meningothelial Mesenchymal Tumor of the Central Nervous System: Case Report and Literature Review.",
"content_text": "Published in Neuropathology on 1 October 2026; matched the OnCo record for CIC.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Neuropathology",
"doi": "10.1111/neup.70079",
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{
"id": "cic",
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},
{
"id": "https://doi.org/10.1097/cji.0000000000000610#onco-edge-paper",
"url": "https://doi.org/10.1097/cji.0000000000000610",
"title": "Nutritional Indexes and Their Variations as Predictors of Atezolizumab Plus Chemotherapy Efficacy in Extensive-Stage Small Cell Lung Cancer: A Turkish Oncology Group Study.",
"content_text": "Published in J Immunother on 1 October 2026; matched the OnCo record for Extensive-stage small-cell lung cancer.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Immunother",
"doi": "10.1097/cji.0000000000000610",
"records": [
{
"id": "extensive-stage-sclc",
"kind": "cancer",
"name": "Extensive-stage small-cell lung cancer",
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},
{
"id": "platinum-etoposide",
"kind": "drug",
"name": "Platinum + etoposide",
"url": "https://onco.cc/drugs/platinum-etoposide/"
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]
}
},
{
"id": "https://doi.org/10.1002/cncr.70549#onco-edge-paper",
"url": "https://doi.org/10.1002/cncr.70549",
"title": "Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo-controlled trial.",
"content_text": "Published in Cancer on 1 October 2026; matched the OnCo record for TET2.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Cancer",
"doi": "10.1002/cncr.70549",
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{
"id": "tet2",
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"url": "https://onco.cc/targets/tet2/"
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},
{
"id": "https://doi.org/10.1002/jcsm.70383#onco-edge-paper",
"url": "https://doi.org/10.1002/jcsm.70383",
"title": "Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.",
"content_text": "Published in J Cachexia Sarcopenia Muscle on 1 October 2026; matched the OnCo record for REST.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Cachexia Sarcopenia Muscle",
"doi": "10.1002/jcsm.70383",
"records": [
{
"id": "rest",
"kind": "target",
"name": "REST",
"url": "https://onco.cc/targets/rest/"
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},
{
"id": "https://doi.org/10.1016/j.hoc.2026.05.028#onco-edge-paper",
"url": "https://doi.org/10.1016/j.hoc.2026.05.028",
"title": "Precision Oncology in Soft Tissue Sarcomas and Gastrointestinal Stromal Tumors.",
"content_text": "Published in Hematol Oncol Clin North Am on 1 October 2026; matched the OnCo record for Gastrointestinal stromal tumour.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Hematol Oncol Clin North Am",
"doi": "10.1016/j.hoc.2026.05.028",
"records": [
{
"id": "gist",
"kind": "cancer",
"name": "Gastrointestinal stromal tumour",
"url": "https://onco.cc/cancers/gist/"
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]
}
},
{
"id": "https://doi.org/10.1002/glia.70210#onco-edge-paper",
"url": "https://doi.org/10.1002/glia.70210",
"title": "Predicting Relevant Microglia-Associated Cell-Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1.",
"content_text": "Published in Glia on 1 October 2026; matched the OnCo record for AXL.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Glia",
"doi": "10.1002/glia.70210",
"records": [
{
"id": "axl",
"kind": "target",
"name": "AXL",
"url": "https://onco.cc/targets/axl/"
},
{
"id": "gas6",
"kind": "target",
"name": "GAS6",
"url": "https://onco.cc/targets/gas6/"
},
{
"id": "itgav",
"kind": "target",
"name": "ITGAV",
"url": "https://onco.cc/targets/itgav/"
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]
}
},
{
"id": "https://doi.org/10.1097/mpa.0000000000002688#onco-edge-paper",
"url": "https://doi.org/10.1097/mpa.0000000000002688",
"title": "Prevalence and Clinical Significance of Abnormal Findings on Pre-Diagnostic Imaging in Pancreatic Ductal Adenocarcinoma.",
"content_text": "Published in Pancreas on 1 October 2026; matched the OnCo record for Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Pancreas",
"doi": "10.1097/mpa.0000000000002688",
"records": [
{
"id": "ipmn-cystic-precursors",
"kind": "cancer",
"name": "Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors",
"url": "https://onco.cc/cancers/ipmn-cystic-precursors/"
}
]
}
},
{
"id": "https://doi.org/10.1111/neup.70077#onco-edge-paper",
"url": "https://doi.org/10.1111/neup.70077",
"title": "Primary Cerebral Pleomorphic-Myxoid Sarcoma With Many Hyaline Globules.",
"content_text": "Published in Neuropathology on 1 October 2026; matched the OnCo record for DICER1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Neuropathology",
"doi": "10.1111/neup.70077",
"records": [
{
"id": "dicer1",
"kind": "target",
"name": "DICER1",
"url": "https://onco.cc/targets/dicer1/"
}
]
}
},
{
"id": "https://doi.org/10.1002/cncy.70153#onco-edge-paper",
"url": "https://doi.org/10.1002/cncy.70153",
"title": "Primary pulmonary salivary gland-type tumors in cytopathology practice: A systematic review and meta-analysis.",
"content_text": "Published in Cancer Cytopathol on 1 October 2026; matched the OnCo record for Mucoepidermoid carcinoma.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Cancer Cytopathol",
"doi": "10.1002/cncy.70153",
"records": [
{
"id": "mucoepidermoid-carcinoma",
"kind": "cancer",
"name": "Mucoepidermoid carcinoma",
"url": "https://onco.cc/cancers/mucoepidermoid-carcinoma/"
},
{
"id": "salivary-gland",
"kind": "cancer",
"name": "Salivary gland cancers",
"url": "https://onco.cc/cancers/salivary-gland/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.celrep.2026.118084#onco-edge-paper",
"url": "https://doi.org/10.1016/j.celrep.2026.118084",
"title": "Progressive remodeling of global protein interaction networks in a mouse model of tauopathy.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics, Atlas and State.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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"doi": "10.1016/j.celrep.2026.118084",
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{
"id": "proteomics",
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"name": "Proteomics & phosphoproteomics",
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},
{
"id": "atlas-aignostics",
"kind": "technology",
"name": "Atlas",
"url": "https://onco.cc/technologies/atlas-aignostics/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
},
{
"id": "msn",
"kind": "target",
"name": "MSN",
"url": "https://onco.cc/targets/msn/"
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}
},
{
"id": "https://doi.org/10.1111/acel.70751#onco-edge-paper",
"url": "https://doi.org/10.1111/acel.70751",
"title": "Protracted Fate Acquisition and Epigenetic De-Aging During Induced Neural Stem Cell Conversion of Human Blood Cells.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, DNA methylation profiling and PAX6.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1111/acel.70751",
"records": [
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
},
{
"id": "methylation-profiling",
"kind": "technology",
"name": "DNA methylation profiling",
"url": "https://onco.cc/technologies/methylation-profiling/"
},
{
"id": "pax6",
"kind": "target",
"name": "PAX6",
"url": "https://onco.cc/targets/pax6/"
},
{
"id": "sox2",
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"url": "https://onco.cc/targets/sox2/"
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]
}
},
{
"id": "https://doi.org/10.1002/jdn.70178#onco-edge-paper",
"url": "https://doi.org/10.1002/jdn.70178",
"title": "PSEN1 Expression Identifies a Developmentally Distinct Favourable-Prognosis State in SHH α Medulloblastoma.",
"content_text": "Published in Int J Dev Neurosci on 1 October 2026; matched the OnCo record for Gamma-secretase.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Int J Dev Neurosci",
"doi": "10.1002/jdn.70178",
"records": [
{
"id": "gamma-secretase",
"kind": "target",
"name": "Gamma-secretase",
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{
"id": "medulloblastoma",
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"url": "https://onco.cc/cancers/medulloblastoma/"
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]
}
},
{
"id": "https://doi.org/10.1111/jmp.70110#onco-edge-paper",
"url": "https://doi.org/10.1111/jmp.70110",
"title": "Pulmonary Tuberculosis in Rhesus Macaque (Macaca mulatta): A Case Report.",
"content_text": "Published in J Med Primatol on 1 October 2026; matched the OnCo record for Medullary thyroid cancer.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Med Primatol",
"doi": "10.1111/jmp.70110",
"records": [
{
"id": "medullary-thyroid-cancer",
"kind": "cancer",
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}
},
{
"id": "https://doi.org/10.1111/mec.70565#onco-edge-paper",
"url": "https://doi.org/10.1111/mec.70565",
"title": "Rates of Evolution Differ Between Cell Types Identified by Single-Cell RNAseq in Threespine Stickleback.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and Single-cell & spatial profiling.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1111/mec.70565",
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{
"id": "rna-seq",
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"name": "RNA sequencing & expression profiling",
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},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
}
]
}
},
{
"id": "https://doi.org/10.36721/pjps.2026.39.10.286.1#onco-edge-paper",
"url": "https://doi.org/10.36721/pjps.2026.39.10.286.1",
"title": "Research on the impact of different chemotherapy and targeted therapy regimens on postoperative disease-free survival in breast cancer patients.",
"content_text": "Published in Pak J Pharm Sci on 1 October 2026; matched the OnCo record for Capecitabine.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Pak J Pharm Sci",
"doi": "10.36721/pjps.2026.39.10.286.1",
"records": [
{
"id": "capecitabine",
"kind": "drug",
"name": "Capecitabine",
"url": "https://onco.cc/drugs/capecitabine/"
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}
},
{
"id": "https://doi.org/10.1002/bmc.70599#onco-edge-paper",
"url": "https://doi.org/10.1002/bmc.70599",
"title": "Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC-MS/MS.",
"content_text": "Published in Biomed Chromatogr on 1 October 2026; matched the OnCo record for Ceralasertib.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Biomed Chromatogr",
"doi": "10.1002/bmc.70599",
"records": [
{
"id": "ceralasertib",
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]
}
},
{
"id": "https://doi.org/10.1002/pri.70323#onco-edge-paper",
"url": "https://doi.org/10.1002/pri.70323",
"title": "Responsiveness, Smallest Detectable Change, and Minimal Important Change of the Turkish Pelvic Floor Distress Inventory-20 Following Pelvic Floor Muscle Training.",
"content_text": "Published in Physiother Res Int on 1 October 2026; matched the OnCo record for Salivary duct carcinoma.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Physiother Res Int",
"doi": "10.1002/pri.70323",
"records": [
{
"id": "salivary-duct-carcinoma",
"kind": "cancer",
"name": "Salivary duct carcinoma",
"url": "https://onco.cc/cancers/salivary-duct-carcinoma/"
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]
}
},
{
"id": "https://doi.org/10.1002/psc.70128#onco-edge-paper",
"url": "https://doi.org/10.1002/psc.70128",
"title": "Sequence Inversion Dictates the Antiproliferative Activity of Bidirectional Tryptophan-Containing Dipeptide Libraries.",
"content_text": "Published in J Pept Sci on 1 October 2026; matched the OnCo record for Mia.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Pept Sci",
"doi": "10.1002/psc.70128",
"records": [
{
"id": "kheiron-mia",
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"url": "https://onco.cc/drugs/kheiron-mia/"
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]
}
},
{
"id": "https://doi.org/10.1021/acsami.6c14858#onco-edge-paper",
"url": "https://doi.org/10.1021/acsami.6c14858",
"title": "Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Pertuzumab and PLK1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1021/acsami.6c14858",
"records": [
{
"id": "pertuzumab",
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},
{
"id": "plk1",
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"url": "https://onco.cc/targets/plk1/"
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]
}
},
{
"id": "https://doi.org/10.1007/s11764-026-02131-0#onco-edge-paper",
"url": "https://doi.org/10.1007/s11764-026-02131-0",
"title": "Supporting implementation of the national standards for cancer survivorship care: development of the cancer survivorship maturity model (CSMM).",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-10-01",
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{
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{
"id": "https://doi.org/10.1097/cji.0000000000000609#onco-edge-paper",
"url": "https://doi.org/10.1097/cji.0000000000000609",
"title": "Talimogene Laherparepvec Response in Recurrent Melanoma During Corticosteroid Replacement for Immune Checkpoint Inhibitor-Induced Adrenal Insufficiency: A Case Report.",
"content_text": "Published in J Immunother on 1 October 2026; matched the OnCo record for Talimogene laherparepvec.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Immunother",
"doi": "10.1097/cji.0000000000000609",
"records": [
{
"id": "talimogene-laherparepvec",
"kind": "drug",
"name": "Talimogene laherparepvec",
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}
]
}
},
{
"id": "https://doi.org/10.1101/gad.353896.126#onco-edge-paper",
"url": "https://doi.org/10.1101/gad.353896.126",
"title": "Temporal gating dictates stress-induced transcript export from the nucleus.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched JUN, FOS and HMOX1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
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"doi": "10.1101/gad.353896.126",
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{
"id": "jun",
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"name": "JUN",
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{
"id": "fos",
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"name": "FOS",
"url": "https://onco.cc/targets/fos/"
},
{
"id": "hmox1",
"kind": "target",
"name": "HMOX1",
"url": "https://onco.cc/targets/hmox1/"
}
]
}
},
{
"id": "https://doi.org/10.1002/bimj.70180#onco-edge-paper",
"url": "https://doi.org/10.1002/bimj.70180",
"title": "The Impact of the Number and the Size of Clusters on Prediction Performance of the Stratified and the Conditional Shared Gamma Frailty Cox Proportional Hazards Models.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched SET.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
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"doi": "10.1002/bimj.70180",
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{
"id": "set",
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"name": "SET",
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]
}
},
{
"id": "https://doi.org/10.1098/rstb.2025.0500#onco-edge-paper",
"url": "https://doi.org/10.1098/rstb.2025.0500",
"title": "The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1098/rstb.2025.0500",
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{
"id": "proteomics",
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"name": "Proteomics & phosphoproteomics",
"url": "https://onco.cc/technologies/proteomics/"
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]
}
},
{
"id": "https://doi.org/10.1371/journal.ppat.1014665#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.ppat.1014665",
"title": "The Mitochondrial ubiquitin ligase MARCHF5 cooperates with MCL1 to inhibit Apoptosis in KSHV-transformed primary effusion lymphoma cell lines.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched Cytotoxic chemotherapy, Proteasome and MCL1.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"doi": "10.1371/journal.ppat.1014665",
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{
"id": "cytotoxic-chemotherapy",
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"name": "Cytotoxic chemotherapy",
"url": "https://onco.cc/technologies/cytotoxic-chemotherapy/"
},
{
"id": "proteasome",
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"name": "Proteasome",
"url": "https://onco.cc/targets/proteasome/"
},
{
"id": "mcl1",
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"name": "MCL1",
"url": "https://onco.cc/targets/mcl1/"
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]
}
},
{
"id": "https://doi.org/10.1111/jhn.70336#onco-edge-paper",
"url": "https://doi.org/10.1111/jhn.70336",
"title": "The Role and Meaning of Hospital Food for Culturally and Linguistically Diverse Patients.",
"content_text": "Published on 1 October 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
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"doi": "10.1111/jhn.70336",
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{
"id": "ccdc6",
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},
{
"id": "https://doi.org/10.1016/j.jhep.2026.07.012#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jhep.2026.07.012",
"title": "The use of locoregional therapies in cholangiocarcinoma.",
"content_text": "Published in J Hepatol on 1 October 2026; matched the OnCo record for Floxuridine.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Hepatol",
"doi": "10.1016/j.jhep.2026.07.012",
"records": [
{
"id": "floxuridine",
"kind": "drug",
"name": "Floxuridine",
"url": "https://onco.cc/drugs/floxuridine/"
},
{
"id": "radioembolisation-tare",
"kind": "technology",
"name": "Radioembolisation",
"url": "https://onco.cc/technologies/radioembolisation-tare/"
},
{
"id": "tace",
"kind": "technology",
"name": "Transarterial chemoembolisation",
"url": "https://onco.cc/technologies/tace/"
}
]
}
},
{
"id": "https://doi.org/10.1002/jgc4.70285#onco-edge-paper",
"url": "https://doi.org/10.1002/jgc4.70285",
"title": "Understanding Barriers and Motivators of Familial Hypercholesterolemia Genetic Testing: Insights From the Singapore Public.",
"content_text": "Published in J Genet Couns on 1 October 2026; matched the OnCo record for FH.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "J Genet Couns",
"doi": "10.1002/jgc4.70285",
"records": [
{
"id": "fh",
"kind": "target",
"name": "FH",
"url": "https://onco.cc/targets/fh/"
}
]
}
},
{
"id": "https://doi.org/10.1111/tct.70518#onco-edge-paper",
"url": "https://doi.org/10.1111/tct.70518",
"title": "Weird, Witty and Worthwhile: Exploring the Benefits of Mnemonic-Based Medical Education.",
"content_text": "Published in Clin Teach on 1 October 2026; matched the OnCo record for Small intestine cancer.",
"date_published": "2026-10-01T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-10-01",
"precision": "day",
"venue": "Clin Teach",
"doi": "10.1111/tct.70518",
"records": [
{
"id": "small-bowel",
"kind": "cancer",
"name": "Small intestine cancer",
"url": "https://onco.cc/cancers/small-bowel/"
},
{
"id": "ccdc6",
"kind": "target",
"name": "CCDC6",
"url": "https://onco.cc/targets/ccdc6/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41423-026-01475-y#onco-edge-paper",
"url": "https://doi.org/10.1038/s41423-026-01475-y",
"title": "CAR signaling instructs divergent metabolic reprogramming and functional fates in αβ and γδ T cells.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched CAR-T cell therapy, JUN and PSCA.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1038/s41423-026-01475-y",
"records": [
{
"id": "car-t",
"kind": "technology",
"name": "CAR-T cell therapy",
"url": "https://onco.cc/technologies/car-t/"
},
{
"id": "jun",
"kind": "target",
"name": "JUN",
"url": "https://onco.cc/targets/jun/"
},
{
"id": "psca",
"kind": "target",
"name": "PSCA",
"url": "https://onco.cc/targets/psca/"
},
{
"id": "fos",
"kind": "target",
"name": "FOS",
"url": "https://onco.cc/targets/fos/"
},
{
"id": "fosb",
"kind": "target",
"name": "FOSB",
"url": "https://onco.cc/targets/fosb/"
}
]
}
},
{
"id": "https://doi.org/10.1186/s12964-026-03219-x#onco-edge-paper",
"url": "https://doi.org/10.1186/s12964-026-03219-x",
"title": "CDK7, CDK9, or CDK11 inhibition reduces neutrophil-driven inflammation and tissue damage in experimental autoimmune models.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched CDK4/6, CDK12 and CDK9.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1186/s12964-026-03219-x",
"records": [
{
"id": "cdk4-6",
"kind": "target",
"name": "CDK4/6",
"url": "https://onco.cc/targets/cdk4-6/"
},
{
"id": "cdk12",
"kind": "target",
"name": "CDK12",
"url": "https://onco.cc/targets/cdk12/"
},
{
"id": "cdk9",
"kind": "target",
"name": "CDK9",
"url": "https://onco.cc/targets/cdk9/"
},
{
"id": "cdk2",
"kind": "target",
"name": "CDK2",
"url": "https://onco.cc/targets/cdk2/"
}
]
}
},
{
"id": "https://doi.org/10.1128/jvi.00834-26#onco-edge-paper",
"url": "https://doi.org/10.1128/jvi.00834-26",
"title": "Changes in the translational landscape during red clover necrotic mosaic virus infection.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1128/jvi.00834-26",
"records": [
{
"id": "rna-seq",
"kind": "technology",
"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.celrep.2026.118035#onco-edge-paper",
"url": "https://doi.org/10.1016/j.celrep.2026.118035",
"title": "Distinct phases of immune system programming during ART-suppressed immunodeficiency virus infection.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1016/j.celrep.2026.118035",
"records": [
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s44319-026-00955-6#onco-edge-paper",
"url": "https://doi.org/10.1038/s44319-026-00955-6",
"title": "Greatwall kinase regulates acute myeloid leukaemia cell division through a non-canonical mechanism.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched MARK3.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1038/s44319-026-00955-6",
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{
"id": "mark3",
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"name": "MARK3",
"url": "https://onco.cc/targets/mark3/"
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]
}
},
{
"id": "https://doi.org/10.1016/j.jaci.2026.08.030#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jaci.2026.08.030",
"title": "Hyperactive STAT1 Promotes T Follicular Helper Type 1 Cell Differentiation to Trigger Autoimmunity.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched STAT1.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1016/j.jaci.2026.08.030",
"records": [
{
"id": "stat1",
"kind": "target",
"name": "STAT1",
"url": "https://onco.cc/targets/stat1/"
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]
}
},
{
"id": "https://doi.org/10.1371/journal.pgen.1012328#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pgen.1012328",
"title": "Immune markers mediate genetic relationships between immune diseases and psychiatric disorders.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched Interleukin-6 and IL-6 receptor.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1371/journal.pgen.1012328",
"records": [
{
"id": "il6",
"kind": "target",
"name": "Interleukin-6 and IL-6 receptor",
"url": "https://onco.cc/targets/il6/"
}
]
}
},
{
"id": "https://doi.org/10.1073/pnas.2614738123#onco-edge-paper",
"url": "https://doi.org/10.1073/pnas.2614738123",
"title": "LAT condensation gates PLCγ1 activation via bimodal LAT phosphorylation.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched Logic-gated therapeutics, State and TEC.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1073/pnas.2614738123",
"records": [
{
"id": "logic-gated-therapeutics",
"kind": "technology",
"name": "Logic-gated therapeutics",
"url": "https://onco.cc/technologies/logic-gated-therapeutics/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
},
{
"id": "tec",
"kind": "target",
"name": "TEC",
"url": "https://onco.cc/targets/tec/"
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]
}
},
{
"id": "https://doi.org/10.1038/s41588-026-02768-8#onco-edge-paper",
"url": "https://doi.org/10.1038/s41588-026-02768-8",
"title": "Lineage identity governs oncogene dependence in mouse NSCLC models of KRAS inhibitor resistance.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched Nintedanib, KRAS & RAS inhibitors and Genetically engineered mouse models.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1038/s41588-026-02768-8",
"records": [
{
"id": "nintedanib",
"kind": "drug",
"name": "Nintedanib",
"url": "https://onco.cc/drugs/nintedanib/"
},
{
"id": "kras-inhibitors",
"kind": "technology",
"name": "KRAS & RAS inhibitors",
"url": "https://onco.cc/technologies/kras-inhibitors/"
},
{
"id": "genetically-engineered-mouse-models",
"kind": "technology",
"name": "Genetically engineered mouse models",
"url": "https://onco.cc/technologies/genetically-engineered-mouse-models/"
},
{
"id": "kras",
"kind": "target",
"name": "KRAS",
"url": "https://onco.cc/targets/kras/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
},
{
"id": "nkx2-1",
"kind": "target",
"name": "NKX2-1",
"url": "https://onco.cc/targets/nkx2-1/"
}
]
}
},
{
"id": "https://doi.org/10.1182/bloodadvances.2026020173#onco-edge-paper",
"url": "https://doi.org/10.1182/bloodadvances.2026020173",
"title": "Novel KIR2DS4:HLA-B*35 interaction predicts HLA-B*35 positive patient survival post hematopoietic stem cell transplant.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched HLA-A, TNFRSF10B and HLA-B.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1182/bloodadvances.2026020173",
"records": [
{
"id": "hla-a",
"kind": "target",
"name": "HLA-A",
"url": "https://onco.cc/targets/hla-a/"
},
{
"id": "tnfrsf10b",
"kind": "target",
"name": "TNFRSF10B",
"url": "https://onco.cc/targets/tnfrsf10b/"
},
{
"id": "hla-b",
"kind": "target",
"name": "HLA-B",
"url": "https://onco.cc/targets/hla-b/"
},
{
"id": "kir2dl1",
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"url": "https://onco.cc/targets/kir2dl1/"
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]
}
},
{
"id": "https://doi.org/10.2147/ijwh.s638707#onco-edge-paper",
"url": "https://doi.org/10.2147/ijwh.s638707",
"title": "Plasma Proteome-Wide Mendelian Randomization with Multi-Layer Triangulation Identifies Druggable Targets for Uterine Leiomyoma.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched PARP inhibitors, PARP and RSPO3.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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"precision": "day",
"doi": "10.2147/ijwh.s638707",
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{
"id": "parp-inhibitor",
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"name": "PARP inhibitors",
"url": "https://onco.cc/technologies/parp-inhibitor/"
},
{
"id": "parp",
"kind": "target",
"name": "PARP",
"url": "https://onco.cc/targets/parp/"
},
{
"id": "rspo3",
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"name": "RSPO3",
"url": "https://onco.cc/targets/rspo3/"
},
{
"id": "eif2ak3",
"kind": "target",
"name": "EIF2AK3",
"url": "https://onco.cc/targets/eif2ak3/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41467-026-78144-1#onco-edge-paper",
"url": "https://doi.org/10.1038/s41467-026-78144-1",
"title": "Programmable DNA protonuclei reveal environmental context on protein phase separation.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched FUS.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1038/s41467-026-78144-1",
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{
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]
}
},
{
"id": "https://doi.org/10.1016/j.cell.2026.09.011#onco-edge-paper",
"url": "https://doi.org/10.1016/j.cell.2026.09.011",
"title": "Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched Sirolimus.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1016/j.cell.2026.09.011",
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{
"id": "sirolimus",
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"name": "Sirolimus",
"url": "https://onco.cc/drugs/sirolimus/"
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]
}
},
{
"id": "https://doi.org/10.1126/sciadv.aeb4023#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aeb4023",
"title": "Sensitizing tumor response to topoisomerase I antibody-drug conjugate by selective CDK7 inhibition.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched Antibody-drug conjugate, Topoisomerase I and MYC.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1126/sciadv.aeb4023",
"records": [
{
"id": "adc",
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"name": "Antibody-drug conjugate",
"url": "https://onco.cc/technologies/adc/"
},
{
"id": "top1",
"kind": "target",
"name": "Topoisomerase I",
"url": "https://onco.cc/targets/top1/"
},
{
"id": "myc-gene",
"kind": "target",
"name": "MYC",
"url": "https://onco.cc/targets/myc-gene/"
}
]
}
},
{
"id": "https://doi.org/10.1073/pnas.2616933123#onco-edge-paper",
"url": "https://doi.org/10.1073/pnas.2616933123",
"title": "Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.",
"content_text": "Published on 30 September 2026 after first appearing as a preprint; matched LPA and MCLA-129.",
"date_published": "2026-09-30T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-30",
"precision": "day",
"doi": "10.1073/pnas.2616933123",
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{
"id": "lpa",
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"name": "LPA",
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},
{
"id": "mcla-129",
"kind": "drug",
"name": "MCLA-129",
"url": "https://onco.cc/drugs/mcla-129/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.prro.2026.07.014#onco-edge-paper",
"url": "https://doi.org/10.1016/j.prro.2026.07.014",
"title": "Androgen Deprivation Therapy (ADT) and Radiotherapy (RT) with Imaging Evaluation Longitudinally (ARIEL) trial: protocol, early results, and implications of neoadjuvant ADT for focal RT boost in prostate cancer.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched Multiparametric prostate MRI, Androgen deprivation & AR pathway inhibitors and MET.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-29",
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"doi": "10.1016/j.prro.2026.07.014",
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{
"id": "mp-mri",
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"name": "Multiparametric prostate MRI",
"url": "https://onco.cc/technologies/mp-mri/"
},
{
"id": "androgen-deprivation",
"kind": "technology",
"name": "Androgen deprivation & AR pathway inhibitors",
"url": "https://onco.cc/technologies/androgen-deprivation/"
},
{
"id": "met",
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"name": "MET",
"url": "https://onco.cc/targets/met/"
},
{
"id": "ell",
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]
}
},
{
"id": "https://doi.org/10.2147/lctt.s642874#onco-edge-paper",
"url": "https://doi.org/10.2147/lctt.s642874",
"title": "Can We Extend Beyond 2 Years of Adjuvant ALK TKI Established by ALINA and ELEVATE in Resected Early Stage <i>ALK+</i> NSCLC a Disease with High Predilection for CNS Metastasis with Novel Clinical Trial Designs?",
"content_text": "Published in Lung Cancer (Auckl) on 29 September 2026; found by the roadmap watch for ALINA.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-29",
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"venue": "Lung Cancer (Auckl)",
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{
"id": "alina",
"kind": "trial",
"name": "ALINA",
"url": "https://onco.cc/trials/alina/"
},
{
"id": "lung-cancer-evidence-roadmap",
"kind": "roadmap",
"name": "Lung cancer roadmap: from Doll and Hill and the naming of tobacco, through the cytotoxic plateau, computed tomography screening, EGFR and ALK, immunotherapy by PD-L1, the perioperative trials and PACIFIC, to DLL3 in small-cell disease and a 2032 registry watch",
"url": "https://onco.cc/roadmaps/lung-cancer-evidence-roadmap/"
},
{
"id": "targeted-therapy-roadmap",
"kind": "roadmap",
"name": "Targeted therapy roadmap: imatinib → designed for resistance → the undruggable drivers fall",
"url": "https://onco.cc/roadmaps/targeted-therapy-roadmap/"
}
]
}
},
{
"id": "https://doi.org/10.1093/bioinformatics/btag726#onco-edge-paper",
"url": "https://doi.org/10.1093/bioinformatics/btag726",
"title": "CSGDA: A Cell State-Guided Graph Domain Adaptation Network for Single-Cell Drug Response Prediction.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched Cisplatin, Single-cell & spatial profiling and Platinum agents.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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{
"id": "cisplatin",
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"name": "Cisplatin",
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{
"id": "single-cell-spatial",
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"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "platinum",
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"name": "Platinum agents",
"url": "https://onco.cc/technologies/platinum/"
},
{
"id": "state-arc",
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"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
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]
}
},
{
"id": "https://doi.org/10.1002/advs.78035#onco-edge-paper",
"url": "https://doi.org/10.1002/advs.78035",
"title": "Long-Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched Senolytics after cancer treatment.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-29",
"precision": "day",
"doi": "10.1002/advs.78035",
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{
"id": "rejuv-frontier-senolytics",
"kind": "technology",
"name": "Senolytics after cancer treatment",
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}
]
}
},
{
"id": "https://doi.org/10.1016/j.bbadis.2026.168486#onco-edge-paper",
"url": "https://doi.org/10.1016/j.bbadis.2026.168486",
"title": "Loss of PIMREG impairs double-strand break signaling and repair.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched Temozolomide, ATR and ATM.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"doi": "10.1016/j.bbadis.2026.168486",
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{
"id": "temozolomide",
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"name": "Temozolomide",
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{
"id": "atr",
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"name": "ATR",
"url": "https://onco.cc/targets/atr/"
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{
"id": "atm",
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"name": "ATM",
"url": "https://onco.cc/targets/atm/"
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}
},
{
"id": "https://doi.org/10.1371/journal.pone.0341400#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pone.0341400",
"title": "Network of interactions between the tumor necrosis factor superfamily members and small S100 proteins.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched CD70 and TNFSF10.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"doi": "10.1371/journal.pone.0341400",
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{
"id": "cd70",
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"name": "CD70",
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{
"id": "tnfsf10",
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},
{
"id": "https://doi.org/10.7554/elife.109268#onco-edge-paper",
"url": "https://doi.org/10.7554/elife.109268",
"title": "Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-29",
"precision": "day",
"doi": "10.7554/elife.109268",
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{
"id": "single-cell-spatial",
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}
]
}
},
{
"id": "https://doi.org/10.1158/2159-8290.cd-25-1596#onco-edge-paper",
"url": "https://doi.org/10.1158/2159-8290.cd-25-1596",
"title": "Spatial modulation of RAF by RAF/MEK glue enables full-dose combination with pan-RAF inhibitor and potent RAS-mutant tumor-selective MAPK and growth inhibition.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched ARAF.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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{
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},
{
"id": "https://doi.org/10.1158/1541-7786.mcr-26-0216#onco-edge-paper",
"url": "https://doi.org/10.1158/1541-7786.mcr-26-0216",
"title": "Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched Azacitidine, Decitabine + cedazuridine and Single-cell & spatial profiling.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-29",
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"doi": "10.1158/1541-7786.mcr-26-0216",
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{
"id": "azacitidine",
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"name": "Azacitidine",
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},
{
"id": "decitabine-cedazuridine",
"kind": "drug",
"name": "Decitabine + cedazuridine",
"url": "https://onco.cc/drugs/decitabine-cedazuridine/"
},
{
"id": "single-cell-spatial",
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"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "spatial-transcriptomics",
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"name": "Spatial transcriptomics",
"url": "https://onco.cc/technologies/spatial-transcriptomics/"
}
]
}
},
{
"id": "https://doi.org/10.1371/journal.pcbi.1014790#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pcbi.1014790",
"title": "Spatiotemporal modeling of GPCR signaling: The role of endosomal dynamics and receptor recycling.",
"content_text": "Published on 29 September 2026 after first appearing as a preprint; matched Abiraterone acetate, Docetaxel and Cisplatin.",
"date_published": "2026-09-29T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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{
"id": "abiraterone",
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"name": "Abiraterone acetate",
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},
{
"id": "docetaxel",
"kind": "drug",
"name": "Docetaxel",
"url": "https://onco.cc/drugs/docetaxel/"
},
{
"id": "cisplatin",
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"name": "Cisplatin",
"url": "https://onco.cc/drugs/cisplatin/"
},
{
"id": "leucovorin",
"kind": "drug",
"name": "Leucovorin",
"url": "https://onco.cc/drugs/leucovorin/"
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]
}
},
{
"id": "https://doi.org/10.1038/s41591-026-04618-w#onco-edge-paper",
"url": "https://doi.org/10.1038/s41591-026-04618-w",
"title": "Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study.",
"content_text": "Published in Nat Med on 22 September 2026; found by the roadmap watch for PATHFINDER 2.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Nat Med",
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{
"id": "pathfinder-2",
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{
"id": "ctdna-tests",
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"name": "ctDNA tests roadmap: from a curiosity in plasma to blood tests that decide treatment",
"url": "https://onco.cc/roadmaps/ctdna-tests/"
},
{
"id": "early-detection-roadmap",
"kind": "roadmap",
"name": "Early detection roadmap: organ screening → blood tests for many cancers",
"url": "https://onco.cc/roadmaps/early-detection-roadmap/"
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]
}
},
{
"id": "https://doi.org/10.1038/s41591-026-04652-8#onco-edge-paper",
"url": "https://doi.org/10.1038/s41591-026-04652-8",
"title": "Performance of a multi-cancer early detection test in the randomized controlled NHS-Galleri trial.",
"content_text": "Published in Nat Med on 22 September 2026; found by the roadmap watch for NHS-Galleri.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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"venue": "Nat Med",
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{
"id": "nhs-galleri",
"kind": "trial",
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{
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"url": "https://onco.cc/roadmaps/ctdna-tests/"
},
{
"id": "early-detection-roadmap",
"kind": "roadmap",
"name": "Early detection roadmap: organ screening → blood tests for many cancers",
"url": "https://onco.cc/roadmaps/early-detection-roadmap/"
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]
}
},
{
"id": "https://doi.org/10.1016/j.cell.2026.08.049#onco-edge-paper",
"url": "https://doi.org/10.1016/j.cell.2026.08.049",
"title": "Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation.",
"content_text": "Published in Cell on 22 September 2026; matched the OnCo record for IRF1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Cell",
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{
"id": "irf1",
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"name": "IRF1",
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{
"id": "spop",
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}
},
{
"id": "https://doi.org/10.1158/2159-8290.cd-25-1652#onco-edge-paper",
"url": "https://doi.org/10.1158/2159-8290.cd-25-1652",
"title": "The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer.",
"content_text": "Published in Cancer Discov on 22 September 2026; matched the OnCo record for BMP2.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Cancer Discov",
"doi": "10.1158/2159-8290.cd-25-1652",
"records": [
{
"id": "bmp2",
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}
},
{
"id": "https://doi.org/10.1073/pnas.2611716123#onco-edge-paper",
"url": "https://doi.org/10.1073/pnas.2611716123",
"title": "A role for heavy chain-modification in protecting hyaluronan from free radical fragmentation during inflammation.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched State and CLTC.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-28",
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"doi": "10.1073/pnas.2611716123",
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{
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"name": "State",
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},
{
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}
},
{
"id": "https://doi.org/10.1016/j.vaccine.2026.129170#onco-edge-paper",
"url": "https://doi.org/10.1016/j.vaccine.2026.129170",
"title": "Aboriginal and Torres Strait Islander adolescent and parent perspectives on human papillomavirus vaccination through the School Immunisation Program in Queensland, Australia: a qualitative study.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched HPV & HBV vaccination and SET.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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{
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},
{
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}
},
{
"id": "https://doi.org/10.1186/s40900-026-00976-4#onco-edge-paper",
"url": "https://doi.org/10.1186/s40900-026-00976-4",
"title": "EXCEL-Punjabi: the process of using a community based participatory research approach for a culturally-tailored exercise oncology intervention.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched Exercise & lifestyle oncology.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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"precision": "day",
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{
"id": "exercise-oncology",
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]
}
},
{
"id": "https://doi.org/10.1038/s41375-026-03145-4#onco-edge-paper",
"url": "https://doi.org/10.1038/s41375-026-03145-4",
"title": "Exploiting an epigenetic resistance mechanism to PI3-kinase inhibition in leukemic stem cells.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched EZH2.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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},
{
"id": "https://doi.org/10.1093/jncics/pkag101#onco-edge-paper",
"url": "https://doi.org/10.1093/jncics/pkag101",
"title": "Genetic and cellular architecture of breast cancer risk across ancestries.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling and Atlas.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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"doi": "10.1093/jncics/pkag101",
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{
"id": "single-cell-spatial",
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},
{
"id": "atlas-aignostics",
"kind": "technology",
"name": "Atlas",
"url": "https://onco.cc/technologies/atlas-aignostics/"
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]
}
},
{
"id": "https://doi.org/10.1007/s12029-026-01604-w#onco-edge-paper",
"url": "https://doi.org/10.1007/s12029-026-01604-w",
"title": "Impact of Socioeconomic Status on Early Gastric Cancer Outcomes and Treatment Disparity: a SEER analysis.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched EDNRA.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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},
{
"id": "https://doi.org/10.1186/s12911-026-03486-1#onco-edge-paper",
"url": "https://doi.org/10.1186/s12911-026-03486-1",
"title": "Interpretable machine learning models for predicting tocilizumab response in rheumatoid arthritis using clinical data.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched Tocilizumab.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-28",
"precision": "day",
"doi": "10.1186/s12911-026-03486-1",
"records": [
{
"id": "tocilizumab",
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"name": "Tocilizumab",
"url": "https://onco.cc/drugs/tocilizumab/"
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]
}
},
{
"id": "https://doi.org/10.1093/infdis/jiag488#onco-edge-paper",
"url": "https://doi.org/10.1093/infdis/jiag488",
"title": "Low birthweight and prematurity, but not malaria chemoprevention, are associated with reduced pneumococcal vaccine immunogenicity in Ugandan infants.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched Chemoprevention & risk-reducing surgery.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-28",
"precision": "day",
"doi": "10.1093/infdis/jiag488",
"records": [
{
"id": "chemoprevention",
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"name": "Chemoprevention & risk-reducing surgery",
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]
}
},
{
"id": "https://doi.org/10.1038/s44318-026-00915-9#onco-edge-paper",
"url": "https://doi.org/10.1038/s44318-026-00915-9",
"title": "MCM10 and SLD-2/RECQL4 jointly activate the CMG helicase during metazoan DNA replication initiation.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched Synthetic lethality approaches and RECQL4.",
"date_published": "2026-09-28T00:00:00Z",
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"paper"
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"_onco": {
"kind": "paper",
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{
"id": "synthetic-lethality-approaches",
"kind": "technology",
"name": "Synthetic lethality approaches",
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{
"id": "recql4",
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"name": "RECQL4",
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}
},
{
"id": "https://doi.org/10.1080/16549716.2026.2735552#onco-edge-paper",
"url": "https://doi.org/10.1080/16549716.2026.2735552",
"title": "Perspectives of women and healthcare providers on facilitators and barriers to cervical cancer screening in the rural Kilimanjaro region Tanzania: a qualitative study.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched CCDC6.",
"date_published": "2026-09-28T00:00:00Z",
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"paper"
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"kind": "paper",
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{
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{
"id": "https://doi.org/10.1208/s12248-026-01295-y#onco-edge-paper",
"url": "https://doi.org/10.1208/s12248-026-01295-y",
"title": "Population Pharmacokinetics and Exposure-response Analysis of Durvalumab in Patients with Limited-stage Small-cell Lung Cancer in the Phase 3 ADRIATIC Study.",
"content_text": "Published in AAPS J on 28 September 2026; found by the roadmap watch for ADRIATIC.",
"date_published": "2026-09-28T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"venue": "AAPS J",
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{
"id": "adriatic",
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"name": "ADRIATIC",
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{
"id": "lung-cancer-evidence-roadmap",
"kind": "roadmap",
"name": "Lung cancer roadmap: from Doll and Hill and the naming of tobacco, through the cytotoxic plateau, computed tomography screening, EGFR and ALK, immunotherapy by PD-L1, the perioperative trials and PACIFIC, to DLL3 in small-cell disease and a 2032 registry watch",
"url": "https://onco.cc/roadmaps/lung-cancer-evidence-roadmap/"
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},
{
"id": "https://doi.org/10.1007/s00404-026-08581-2#onco-edge-paper",
"url": "https://doi.org/10.1007/s00404-026-08581-2",
"title": "Risk-reducing salpingo-oophorectomy in patients with gBRCA-mutated breast cancer.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched HER2, BRCA1 / BRCA2 and EGF.",
"date_published": "2026-09-28T00:00:00Z",
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"paper"
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"kind": "paper",
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{
"id": "her2",
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},
{
"id": "brca",
"kind": "target",
"name": "BRCA1 / BRCA2",
"url": "https://onco.cc/targets/brca/"
},
{
"id": "egf",
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"name": "EGF",
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}
},
{
"id": "https://doi.org/10.12688/f1000research.188625.2#onco-edge-paper",
"url": "https://doi.org/10.12688/f1000research.188625.2",
"title": "The Beekeeping Sector of Kazakhstan and Contributions to the Pharmaceutical Industry: Promising Flavonoids with the Pharmacokinetic Properties Via the Computational Evaluations.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched ABCB1.",
"date_published": "2026-09-28T00:00:00Z",
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"paper"
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"_onco": {
"kind": "paper",
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{
"id": "abcb1",
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},
{
"id": "https://doi.org/10.1007/s10552-026-02259-5#onco-edge-paper",
"url": "https://doi.org/10.1007/s10552-026-02259-5",
"title": "The relationship between activities of daily living, frailty, and care dependency in older adults with lung cancer.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched MET and Frailty and late effects in survivors.",
"date_published": "2026-09-28T00:00:00Z",
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"paper"
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"_onco": {
"kind": "paper",
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{
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},
{
"id": "rejuv-age-frailty-and-late-effects",
"kind": "technology",
"name": "Frailty and late effects in survivors",
"url": "https://onco.cc/technologies/rejuv-age-frailty-and-late-effects/"
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}
},
{
"id": "https://doi.org/10.1038/s44319-026-00941-y#onco-edge-paper",
"url": "https://doi.org/10.1038/s44319-026-00941-y",
"title": "UHRF1 overexpression generates distinct senescent states with different Tp53 dependencies.",
"content_text": "Published on 28 September 2026 after first appearing as a preprint; matched TP53, Senolytics after cancer treatment and ATM.",
"date_published": "2026-09-28T00:00:00Z",
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"paper"
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"kind": "paper",
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{
"id": "tp53",
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{
"id": "rejuv-frontier-senolytics",
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"name": "Senolytics after cancer treatment",
"url": "https://onco.cc/technologies/rejuv-frontier-senolytics/"
},
{
"id": "atm",
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"name": "ATM",
"url": "https://onco.cc/targets/atm/"
},
{
"id": "navitoclax",
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"name": "Navitoclax",
"url": "https://onco.cc/drugs/navitoclax/"
}
]
}
},
{
"id": "https://doi.org/10.1182/blood.2026034660#onco-edge-paper",
"url": "https://doi.org/10.1182/blood.2026034660",
"title": "Melatonin, circadian metabolism, mitochondrial remodeling, and cell size dynamics in primitive hematopoietic stem cells.",
"content_text": "Published in Blood on 21 September 2026; matched the OnCo record for LMNA.",
"date_published": "2026-09-21T00:00:00Z",
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"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Blood",
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{
"id": "lmna",
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"name": "LMNA",
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}
},
{
"id": "https://doi.org/10.1002/advs.78010#onco-edge-paper",
"url": "https://doi.org/10.1002/advs.78010",
"title": "Acoustically Activatable Drug-Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors.",
"content_text": "Published on 27 September 2026 after first appearing as a preprint; matched Ultrasound.",
"date_published": "2026-09-27T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-27",
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"doi": "10.1002/advs.78010",
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{
"id": "ultrasound",
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"name": "Ultrasound",
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]
}
},
{
"id": "https://doi.org/10.1002/pros.70259#onco-edge-paper",
"url": "https://doi.org/10.1002/pros.70259",
"title": "Is a Few Too Many? Alcohol Consumption and Prostate Cancer Upgrading During Active Surveillance.",
"content_text": "Published on 27 September 2026 after first appearing as a preprint; matched Active surveillance and ELL.",
"date_published": "2026-09-27T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-27",
"precision": "day",
"doi": "10.1002/pros.70259",
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{
"id": "active-surveillance",
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"name": "Active surveillance",
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{
"id": "ell",
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}
},
{
"id": "https://doi.org/10.1007/s00429-026-03166-w#onco-edge-paper",
"url": "https://doi.org/10.1007/s00429-026-03166-w",
"title": "Autoencoders for unsupervised analysis of rat myeloarchitecture.",
"content_text": "Published on 26 September 2026 after first appearing as a preprint; matched Pathology & radiology foundation models.",
"date_published": "2026-09-26T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-26",
"precision": "day",
"doi": "10.1007/s00429-026-03166-w",
"records": [
{
"id": "pathology-foundation-model",
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"name": "Pathology & radiology foundation models",
"url": "https://onco.cc/technologies/pathology-foundation-model/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.jconrel.2026.115414#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jconrel.2026.115414",
"title": "Collagen targeting IL-12 combined with doxorubicin enhances the anti-tumor effect against osteosarcoma.",
"content_text": "Published on 26 September 2026 after first appearing as a preprint; matched Doxorubicin and VWF.",
"date_published": "2026-09-26T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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{
"id": "doxorubicin",
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},
{
"id": "vwf",
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]
}
},
{
"id": "https://doi.org/10.1007/s12308-026-00737-y#onco-edge-paper",
"url": "https://doi.org/10.1007/s12308-026-00737-y",
"title": "Primary ALK-positive anaplastic large cell lymphoma of the urinary bladder in a pediatric patient: a case report and review of literature.",
"content_text": "Published on 26 September 2026 after first appearing as a preprint; matched CD30, CT and ALK.",
"date_published": "2026-09-26T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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{
"id": "ct",
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"name": "CT",
"url": "https://onco.cc/technologies/ct/"
},
{
"id": "alk",
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"name": "ALK",
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},
{
"id": "brentuximab-vedotin",
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"name": "Brentuximab vedotin",
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}
},
{
"id": "https://doi.org/10.1093/neuonc/noag235#onco-edge-paper",
"url": "https://doi.org/10.1093/neuonc/noag235",
"title": "Stem cell morphology defines functional heterogeneity and therapeutic vulnerabilities in glioblastoma.",
"content_text": "Published on 26 September 2026 after first appearing as a preprint; matched Temozolomide, Single-cell & spatial profiling and Patient-derived organoids.",
"date_published": "2026-09-26T00:00:00Z",
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"id": "temozolomide",
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{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "organoids",
"kind": "technology",
"name": "Patient-derived organoids",
"url": "https://onco.cc/technologies/organoids/"
},
{
"id": "spatial-transcriptomics",
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"name": "Spatial transcriptomics",
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},
{
"id": "state-arc",
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}
},
{
"id": "https://doi.org/10.1038/s42003-026-10898-2#onco-edge-paper",
"url": "https://doi.org/10.1038/s42003-026-10898-2",
"title": "Unexpected functional role of the transactivation domain for nuclear import of STAT5.",
"content_text": "Published on 26 September 2026 after first appearing as a preprint; matched Erythropoietin receptor and STAT5.",
"date_published": "2026-09-26T00:00:00Z",
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"_onco": {
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"id": "epor",
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"name": "Erythropoietin receptor",
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{
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}
},
{
"id": "https://doi.org/10.1126/sciadv.aeh0675#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aeh0675",
"title": "Converting lysosomes into photothermal organelles enables nanoparticle-free tumor ablation via intracellular vapor bubbles.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Sunitinib.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"precision": "day",
"doi": "10.1126/sciadv.aeh0675",
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{
"id": "sunitinib",
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}
},
{
"id": "https://doi.org/10.1080/15592294.2026.2732477#onco-edge-paper",
"url": "https://doi.org/10.1080/15592294.2026.2732477",
"title": "Differential methylation at novel putative imprinting control regions on chromosome 20 associated with childhood obesity.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched DNA methylation profiling.",
"date_published": "2026-09-25T00:00:00Z",
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"paper"
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"_onco": {
"kind": "paper",
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"id": "methylation-profiling",
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]
}
},
{
"id": "https://doi.org/10.1080/15459624.2026.2721327#onco-edge-paper",
"url": "https://doi.org/10.1080/15459624.2026.2721327",
"title": "Evolution of occupational health risks among waste incinerator workers: A four-decade review.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched CFLAR.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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},
{
"id": "https://doi.org/10.1126/sciadv.aeh7889#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aeh7889",
"title": "FACT-(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched H3C14.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"doi": "10.1126/sciadv.aeh7889",
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},
{
"id": "https://doi.org/10.1371/journal.pcbi.1014034#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pcbi.1014034",
"title": "Fast structural search for classification of gut bacterial mucin O-glycan degrading enzymes.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched State.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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"doi": "10.1371/journal.pcbi.1014034",
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}
},
{
"id": "https://doi.org/10.1007/s00604-026-08422-8#onco-edge-paper",
"url": "https://doi.org/10.1007/s00604-026-08422-8",
"title": "Fe<sub>3</sub>O<sub>4</sub>-Au cluster-satellite particles as direct colorimetric reporters in a smartphone-quantified lateral flow immunoassay for prostate-specific antigen.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched KLK2 and KLK3.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
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{
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}
},
{
"id": "https://doi.org/10.1038/s41431-026-02244-1#onco-edge-paper",
"url": "https://doi.org/10.1038/s41431-026-02244-1",
"title": "Interdisciplinary management and genetic evaluation of pediatric cancer predisposition syndromes: a retrospective cohort study.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Germline (hereditary) testing.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
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]
}
},
{
"id": "https://doi.org/10.1126/sciadv.aec8202#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aec8202",
"title": "Optical microscopy predictions of focal recurrence in glioblastoma.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Cytotoxic chemotherapy.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
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}
},
{
"id": "https://doi.org/10.1016/j.neo.2026.101371#onco-edge-paper",
"url": "https://doi.org/10.1016/j.neo.2026.101371",
"title": "PDLIM2 in lung adenocarcinoma metastasis.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched KRAS, TP53 and ELL.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
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],
"_onco": {
"kind": "paper",
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{
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{
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},
{
"id": "https://doi.org/10.2174/0115734056499038260921072239#onco-edge-paper",
"url": "https://doi.org/10.2174/0115734056499038260921072239",
"title": "Preoperative Noninvasive Assessment for Predicting Steatosis Grade in Hepatocellular Carcinoma Patients with Chronic Hepatitis B: Comparison of Attenuation Imaging with Controlled Attenuation Parameter.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Ultrasound, PSMD2 and PSMD1.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-25",
"precision": "day",
"doi": "10.2174/0115734056499038260921072239",
"records": [
{
"id": "ultrasound",
"kind": "technology",
"name": "Ultrasound",
"url": "https://onco.cc/technologies/ultrasound/"
},
{
"id": "psmd2",
"kind": "target",
"name": "PSMD2",
"url": "https://onco.cc/targets/psmd2/"
},
{
"id": "psmd1",
"kind": "target",
"name": "PSMD1",
"url": "https://onco.cc/targets/psmd1/"
},
{
"id": "tg",
"kind": "target",
"name": "TG",
"url": "https://onco.cc/targets/tg/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s00418-026-02532-3#onco-edge-paper",
"url": "https://doi.org/10.1007/s00418-026-02532-3",
"title": "Proteomic study for the prediction of μ CT imaging with iodine.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Atlas, FLG and SET.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-25",
"precision": "day",
"doi": "10.1007/s00418-026-02532-3",
"records": [
{
"id": "atlas-aignostics",
"kind": "technology",
"name": "Atlas",
"url": "https://onco.cc/technologies/atlas-aignostics/"
},
{
"id": "flg",
"kind": "target",
"name": "FLG",
"url": "https://onco.cc/targets/flg/"
},
{
"id": "set",
"kind": "target",
"name": "SET",
"url": "https://onco.cc/targets/set/"
}
]
}
},
{
"id": "https://doi.org/10.1126/sciimmunol.aeb8726#onco-edge-paper",
"url": "https://doi.org/10.1126/sciimmunol.aeb8726",
"title": "Specific targeting of MR1-antigen complexes using nanobodies.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Bispecific antibodies, CD3 and HLA-A.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-25",
"precision": "day",
"doi": "10.1126/sciimmunol.aeb8726",
"records": [
{
"id": "bispecific-antibody",
"kind": "technology",
"name": "Bispecific antibodies",
"url": "https://onco.cc/technologies/bispecific-antibody/"
},
{
"id": "cd3",
"kind": "target",
"name": "CD3",
"url": "https://onco.cc/targets/cd3/"
},
{
"id": "hla-a",
"kind": "target",
"name": "HLA-A",
"url": "https://onco.cc/targets/hla-a/"
},
{
"id": "mcla-129",
"kind": "drug",
"name": "MCLA-129",
"url": "https://onco.cc/drugs/mcla-129/"
}
]
}
},
{
"id": "https://doi.org/10.1371/journal.pcbi.1014801#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pcbi.1014801",
"title": "Topologically-based parameter inference for agent-based model selection from spatiotemporal cellular data.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling and Nicheformer.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-25",
"precision": "day",
"doi": "10.1371/journal.pcbi.1014801",
"records": [
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "nicheformer",
"kind": "technology",
"name": "Nicheformer",
"url": "https://onco.cc/technologies/nicheformer/"
}
]
}
},
{
"id": "https://doi.org/10.7554/elife.111443#onco-edge-paper",
"url": "https://doi.org/10.7554/elife.111443",
"title": "Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and GyrB.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched State, Mismatch repair proteins and MLH1.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-25",
"precision": "day",
"doi": "10.7554/elife.111443",
"records": [
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
},
{
"id": "mmr",
"kind": "target",
"name": "Mismatch repair proteins",
"url": "https://onco.cc/targets/mmr/"
},
{
"id": "mlh1",
"kind": "target",
"name": "MLH1",
"url": "https://onco.cc/targets/mlh1/"
},
{
"id": "pms2",
"kind": "target",
"name": "PMS2",
"url": "https://onco.cc/targets/pms2/"
},
{
"id": "hsp90aa1",
"kind": "target",
"name": "HSP90AA1",
"url": "https://onco.cc/targets/hsp90aa1/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s12013-026-02188-9#onco-edge-paper",
"url": "https://doi.org/10.1007/s12013-026-02188-9",
"title": "Umbilical Cord Mesenchymal Stem Cells Improve PINK1/PARKIN-Mediated Mitophagy Inhibition in Preeclampsia.",
"content_text": "Published on 25 September 2026 after first appearing as a preprint; matched Mesenchymal stromal cells for tissue damage.",
"date_published": "2026-09-25T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-25",
"precision": "day",
"doi": "10.1007/s12013-026-02188-9",
"records": [
{
"id": "rejuv-frontier-mesenchymal-stromal-cells",
"kind": "technology",
"name": "Mesenchymal stromal cells for tissue damage",
"url": "https://onco.cc/technologies/rejuv-frontier-mesenchymal-stromal-cells/"
}
]
}
},
{
"id": "https://doi.org/10.1200/jco-25-02737#onco-edge-paper",
"url": "https://doi.org/10.1200/jco-25-02737",
"title": "Association Between Patient-Reported Outcomes and Health Care Resource Utilization: Toward Developing Patient-Centered Value Measures in Cancer Care.",
"content_text": "Published in J Clin Oncol on 18 September 2026; matched the OnCo record for Early-stage classical Hodgkin lymphoma.",
"date_published": "2026-09-18T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-18",
"precision": "day",
"venue": "J Clin Oncol",
"doi": "10.1200/jco-25-02737",
"records": [
{
"id": "early-stage-classical-hodgkin-lymphoma",
"kind": "cancer",
"name": "Early-stage classical Hodgkin lymphoma",
"url": "https://onco.cc/cancers/early-stage-classical-hodgkin-lymphoma/"
}
]
}
},
{
"id": "https://doi.org/10.1158/2159-8290.cd-nw2026-0090#onco-edge-paper",
"url": "https://doi.org/10.1158/2159-8290.cd-nw2026-0090",
"title": "Phase III Trials Test First-Line Options in Advanced NSCLC.",
"content_text": "Published in Cancer Discov on 18 September 2026; matched the OnCo record for Amivantamab.",
"date_published": "2026-09-18T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-18",
"precision": "day",
"venue": "Cancer Discov",
"doi": "10.1158/2159-8290.cd-nw2026-0090",
"records": [
{
"id": "amivantamab",
"kind": "drug",
"name": "Amivantamab",
"url": "https://onco.cc/drugs/amivantamab/"
},
{
"id": "ivonescimab",
"kind": "drug",
"name": "Ivonescimab",
"url": "https://onco.cc/drugs/ivonescimab/"
},
{
"id": "zipalertinib",
"kind": "drug",
"name": "Zipalertinib",
"url": "https://onco.cc/drugs/zipalertinib/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.ccell.2026.08.015#onco-edge-paper",
"url": "https://doi.org/10.1016/j.ccell.2026.08.015",
"title": "γδ T cells modulate anti-tumor immunity in small cell lung cancer.",
"content_text": "Published in Cancer Cell on 18 September 2026; matched the OnCo record for Zoledronic acid.",
"date_published": "2026-09-18T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-18",
"precision": "day",
"venue": "Cancer Cell",
"doi": "10.1016/j.ccell.2026.08.015",
"records": [
{
"id": "zoledronic-acid",
"kind": "drug",
"name": "Zoledronic acid",
"url": "https://onco.cc/drugs/zoledronic-acid/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "t-cell-engager",
"kind": "technology",
"name": "T-cell engagers",
"url": "https://onco.cc/technologies/t-cell-engager/"
},
{
"id": "dll3",
"kind": "target",
"name": "DLL3",
"url": "https://onco.cc/targets/dll3/"
},
{
"id": "cd3",
"kind": "target",
"name": "CD3",
"url": "https://onco.cc/targets/cd3/"
},
{
"id": "pd1",
"kind": "target",
"name": "PD-1",
"url": "https://onco.cc/targets/pd1/"
},
{
"id": "pdl1",
"kind": "target",
"name": "PD-L1",
"url": "https://onco.cc/targets/pdl1/"
}
]
}
},
{
"id": "https://doi.org/10.1182/bloodadvances.2026019911#onco-edge-paper",
"url": "https://doi.org/10.1182/bloodadvances.2026019911",
"title": "A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling, GATA2 and STAG2.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1182/bloodadvances.2026019911",
"records": [
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "gata2",
"kind": "target",
"name": "GATA2",
"url": "https://onco.cc/targets/gata2/"
},
{
"id": "stag2",
"kind": "target",
"name": "STAG2",
"url": "https://onco.cc/targets/stag2/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s10048-026-00944-w#onco-edge-paper",
"url": "https://doi.org/10.1007/s10048-026-00944-w",
"title": "A rare ATM variant in a Colombian family with chorea-ataxia syndrome: implications for an early diagnosis.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched Whole-exome & whole-genome sequencing and ATM.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1007/s10048-026-00944-w",
"records": [
{
"id": "wes-wgs",
"kind": "technology",
"name": "Whole-exome & whole-genome sequencing",
"url": "https://onco.cc/technologies/wes-wgs/"
},
{
"id": "atm",
"kind": "target",
"name": "ATM",
"url": "https://onco.cc/targets/atm/"
}
]
}
},
{
"id": "https://doi.org/10.1523/jneurosci.0240-26.2026#onco-edge-paper",
"url": "https://doi.org/10.1523/jneurosci.0240-26.2026",
"title": "ASCL1 and OLIG2 Expression Dynamics Control Glial Cell Fate and Regional Diversity in the Dorsal Forebrain.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched State, ASCL1 and OLIG2.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1523/jneurosci.0240-26.2026",
"records": [
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
},
{
"id": "ascl1",
"kind": "target",
"name": "ASCL1",
"url": "https://onco.cc/targets/ascl1/"
},
{
"id": "olig2",
"kind": "target",
"name": "OLIG2",
"url": "https://onco.cc/targets/olig2/"
}
]
}
},
{
"id": "https://doi.org/10.1093/bioinformatics/btag714#onco-edge-paper",
"url": "https://doi.org/10.1093/bioinformatics/btag714",
"title": "DesignMaster: A Multi-Conditional Diffusion Framework for Rational PROTAC Design.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched PROTACs & molecular glues.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1093/bioinformatics/btag714",
"records": [
{
"id": "protac-degrader",
"kind": "technology",
"name": "PROTACs & molecular glues",
"url": "https://onco.cc/technologies/protac-degrader/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s00520-026-11179-8#onco-edge-paper",
"url": "https://doi.org/10.1007/s00520-026-11179-8",
"title": "Exploring the feasibility of exercise training during (neo)adjuvant chemotherapy in women with early-stage breast cancer: a pilot study examining immune and metabolic outcomes.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched Exercise & lifestyle oncology.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1007/s00520-026-11179-8",
"records": [
{
"id": "exercise-oncology",
"kind": "technology",
"name": "Exercise & lifestyle oncology",
"url": "https://onco.cc/technologies/exercise-oncology/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41388-026-03997-1#onco-edge-paper",
"url": "https://doi.org/10.1038/s41388-026-03997-1",
"title": "Phylogenetic and phylodynamic approaches to understanding the evolution of non-small cell lung cancer using single-cell sequencing.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched Nintedanib, Whole-exome & whole-genome sequencing and Single-cell & spatial profiling.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1038/s41388-026-03997-1",
"records": [
{
"id": "nintedanib",
"kind": "drug",
"name": "Nintedanib",
"url": "https://onco.cc/drugs/nintedanib/"
},
{
"id": "wes-wgs",
"kind": "technology",
"name": "Whole-exome & whole-genome sequencing",
"url": "https://onco.cc/technologies/wes-wgs/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s00280-026-04951-4#onco-edge-paper",
"url": "https://doi.org/10.1007/s00280-026-04951-4",
"title": "Population pharmacokinetic analysis of pirtobrutinib, a non-covalent BTK inhibitor, in patients with hematological malignancies from the Phase 1/2 BRUIN study.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched BTK, Pirtobrutinib and State.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1007/s00280-026-04951-4",
"records": [
{
"id": "btk",
"kind": "target",
"name": "BTK",
"url": "https://onco.cc/targets/btk/"
},
{
"id": "pirtobrutinib",
"kind": "drug",
"name": "Pirtobrutinib",
"url": "https://onco.cc/drugs/pirtobrutinib/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.ejca.2026.117064#onco-edge-paper",
"url": "https://doi.org/10.1016/j.ejca.2026.117064",
"title": "Reflections on adjuvant pembrolizumab for triple-negative breast cancer treated with the KEYNOTE-522 regimen: Is it really necessary?",
"content_text": "Published in Eur J Cancer on 24 September 2026; found by the roadmap watch for KEYNOTE-522.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"venue": "Eur J Cancer",
"doi": "10.1016/j.ejca.2026.117064",
"records": [
{
"id": "keynote-522",
"kind": "trial",
"name": "KEYNOTE-522",
"url": "https://onco.cc/trials/keynote-522/"
},
{
"id": "immunotherapy-roadmap",
"kind": "roadmap",
"name": "Immunotherapy roadmap: Coley's toxins → checkpoint inhibitors → engineered immunity",
"url": "https://onco.cc/roadmaps/immunotherapy-roadmap/"
},
{
"id": "surgery-roadmap",
"kind": "roadmap",
"name": "Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work",
"url": "https://onco.cc/roadmaps/surgery-roadmap/"
},
{
"id": "tnbc-history",
"kind": "roadmap",
"name": "TNBC roadmap: from 'nothing to target' to ADC + immunotherapy first line",
"url": "https://onco.cc/roadmaps/tnbc-history/"
},
{
"id": "trial-modernisation-roadmap",
"kind": "roadmap",
"name": "Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on",
"url": "https://onco.cc/roadmaps/trial-modernisation-roadmap/"
},
{
"id": "tnbc-roadmap",
"kind": "roadmap",
"name": "Triple-negative breast cancer roadmap: from a remainder defined by three negative tests to immunotherapy, antibody-drug conjugates and the residual disease problem",
"url": "https://onco.cc/roadmaps/tnbc-roadmap/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41375-026-03139-2#onco-edge-paper",
"url": "https://doi.org/10.1038/s41375-026-03139-2",
"title": "Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling.",
"content_text": "Published on 24 September 2026 after first appearing as a preprint; matched Fedratinib, JAK2 and MPL.",
"date_published": "2026-09-24T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-24",
"precision": "day",
"doi": "10.1038/s41375-026-03139-2",
"records": [
{
"id": "fedratinib",
"kind": "drug",
"name": "Fedratinib",
"url": "https://onco.cc/drugs/fedratinib/"
},
{
"id": "jak2",
"kind": "target",
"name": "JAK2",
"url": "https://onco.cc/targets/jak2/"
},
{
"id": "mpl",
"kind": "target",
"name": "MPL",
"url": "https://onco.cc/targets/mpl/"
},
{
"id": "calr",
"kind": "target",
"name": "CALR",
"url": "https://onco.cc/targets/calr/"
},
{
"id": "tyk2",
"kind": "target",
"name": "TYK2",
"url": "https://onco.cc/targets/tyk2/"
},
{
"id": "ednra",
"kind": "target",
"name": "EDNRA",
"url": "https://onco.cc/targets/ednra/"
}
]
}
},
{
"id": "https://doi.org/10.1126/science.aec6129#onco-edge-paper",
"url": "https://doi.org/10.1126/science.aec6129",
"title": "An expert-level generalist AI for abdominal CT diagnosis.",
"content_text": "Published in Science on 17 September 2026; matched the OnCo record for RaDaR.",
"date_published": "2026-09-17T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-17",
"precision": "day",
"venue": "Science",
"doi": "10.1126/science.aec6129",
"records": [
{
"id": "radar-mrd",
"kind": "drug",
"name": "RaDaR",
"url": "https://onco.cc/drugs/radar-mrd/"
}
]
}
},
{
"id": "https://doi.org/10.1158/2159-8290.cd-nw2026-0088#onco-edge-paper",
"url": "https://doi.org/10.1158/2159-8290.cd-nw2026-0088",
"title": "Anti-B7-H3 ADCs Take Center Stage against SCLC at WCLC.",
"content_text": "Published in Cancer Discov on 17 September 2026; matched the OnCo record for YL201.",
"date_published": "2026-09-17T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-17",
"precision": "day",
"venue": "Cancer Discov",
"doi": "10.1158/2159-8290.cd-nw2026-0088",
"records": [
{
"id": "yl201",
"kind": "drug",
"name": "YL201",
"url": "https://onco.cc/drugs/yl201/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41591-026-04646-6#onco-edge-paper",
"url": "https://doi.org/10.1038/s41591-026-04646-6",
"title": "Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma.",
"content_text": "Published in Nat Med on 17 September 2026; matched the OnCo record for Diffuse midline glioma, H3 K27-altered.",
"date_published": "2026-09-17T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-17",
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"venue": "Nat Med",
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{
"id": "dipg-dmg",
"kind": "cancer",
"name": "Diffuse midline glioma, H3 K27-altered",
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}
},
{
"id": "https://doi.org/10.1016/j.annonc.2026.09.005#onco-edge-paper",
"url": "https://doi.org/10.1016/j.annonc.2026.09.005",
"title": "Navigating uncertainties and evidence gaps in adjuvant therapy for premenopausal women with HR+/HER2- breast cancer.",
"content_text": "Published in Ann Oncol on 17 September 2026; matched the OnCo record for Goserelin / leuprolide.",
"date_published": "2026-09-17T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-17",
"precision": "day",
"venue": "Ann Oncol",
"doi": "10.1016/j.annonc.2026.09.005",
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{
"id": "goserelin",
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"name": "Goserelin / leuprolide",
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},
{
"id": "https://doi.org/10.1530/erc-26-0314#onco-edge-paper",
"url": "https://doi.org/10.1530/erc-26-0314",
"title": "18F-CETO in Adrenocortical Carcinoma: First Clinical-Translational Study of An Adrenocortical-targeting PET Tracer.",
"content_text": "Published in Endocr Relat Cancer on 23 September 2026; matched the OnCo record for CYP11B1.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
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"venue": "Endocr Relat Cancer",
"doi": "10.1530/erc-26-0314",
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{
"id": "cyp11b1",
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}
},
{
"id": "https://doi.org/10.1038/s42003-026-10743-6#onco-edge-paper",
"url": "https://doi.org/10.1038/s42003-026-10743-6",
"title": "A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal inhibitor that binds the peptidyl transferase center.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Elongation factor 2 and State.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
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"doi": "10.1038/s42003-026-10743-6",
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{
"id": "eef2",
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"name": "Elongation factor 2",
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{
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}
},
{
"id": "https://doi.org/10.1002/advs.77757#onco-edge-paper",
"url": "https://doi.org/10.1002/advs.77757",
"title": "A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence.",
"content_text": "Published in Adv Sci (Weinh) on 23 September 2026; matched the OnCo record for HMGA2.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
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"venue": "Adv Sci (Weinh)",
"doi": "10.1002/advs.77757",
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{
"id": "hmga2",
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},
{
"id": "https://doi.org/10.1080/19490976.2026.2736902#onco-edge-paper",
"url": "https://doi.org/10.1080/19490976.2026.2736902",
"title": "A probiotic <i>Bifidobacterium pseudocatenulatum</i> converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice.",
"content_text": "Published in Gut Microbes on 23 September 2026; matched the OnCo record for SIRT1.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
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"venue": "Gut Microbes",
"doi": "10.1080/19490976.2026.2736902",
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{
"id": "sirt1",
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"name": "SIRT1",
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{
"id": "https://doi.org/10.1002/1878-0261.70295#onco-edge-paper",
"url": "https://doi.org/10.1002/1878-0261.70295",
"title": "Cancer-associated mutations in endometriosis reframe a benign disease through molecular oncology.",
"content_text": "Published in Mol Oncol on 23 September 2026; matched the OnCo record for ARID1A.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
"precision": "day",
"venue": "Mol Oncol",
"doi": "10.1002/1878-0261.70295",
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{
"id": "arid1a",
"kind": "target",
"name": "ARID1A",
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{
"id": "https://doi.org/10.1038/s41467-026-75680-8#onco-edge-paper",
"url": "https://doi.org/10.1038/s41467-026-75680-8",
"title": "Efficient differential expression analysis of large-scale single-cell transcriptomics data using Dreamlet.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
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"doi": "10.1038/s41467-026-75680-8",
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{
"id": "single-cell-spatial",
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]
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},
{
"id": "https://doi.org/10.1152/ajpcell.00626.2025#onco-edge-paper",
"url": "https://doi.org/10.1152/ajpcell.00626.2025",
"title": "Establishment of a cell line-based 3D co-culture model of the endometrium for studying endometrial receptivity.",
"content_text": "Published in Am J Physiol Cell Physiol on 23 September 2026; matched the OnCo record for HEY1.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
"precision": "day",
"venue": "Am J Physiol Cell Physiol",
"doi": "10.1152/ajpcell.00626.2025",
"records": [
{
"id": "hey1",
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"name": "HEY1",
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},
{
"id": "https://doi.org/10.2340/1651-226x.2026.46486#onco-edge-paper",
"url": "https://doi.org/10.2340/1651-226x.2026.46486",
"title": "Exceptional response to alpelisib in a heavily pretreated patient with metastatic breast cancer carrying a PIK3CA mutation outside SOLAR-1 eligible mutations: a case report.",
"content_text": "Published in Acta Oncol on 23 September 2026; found by the roadmap watch for SOLAR-1.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
"precision": "day",
"venue": "Acta Oncol",
"doi": "10.2340/1651-226x.2026.46486",
"records": [
{
"id": "solar-1",
"kind": "trial",
"name": "SOLAR-1",
"url": "https://onco.cc/trials/solar-1/"
},
{
"id": "hormonal-therapy-roadmap",
"kind": "roadmap",
"name": "Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test",
"url": "https://onco.cc/roadmaps/hormonal-therapy-roadmap/"
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]
}
},
{
"id": "https://doi.org/10.1038/s41467-026-75681-7#onco-edge-paper",
"url": "https://doi.org/10.1038/s41467-026-75681-7",
"title": "Fast, flexible analysis of differences in cellular composition with crumblr.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
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"doi": "10.1038/s41467-026-75681-7",
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{
"id": "single-cell-spatial",
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]
}
},
{
"id": "https://doi.org/10.1242/jcs.264937#onco-edge-paper",
"url": "https://doi.org/10.1242/jcs.264937",
"title": "FGD1 restrains actomyosin contractility to promote suprabasal junction maturation in stratified keratinocytes.",
"content_text": "Published in J Cell Sci on 23 September 2026; matched the OnCo record for FGD1.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
"precision": "day",
"venue": "J Cell Sci",
"doi": "10.1242/jcs.264937",
"records": [
{
"id": "fgd1",
"kind": "target",
"name": "FGD1",
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},
{
"id": "https://doi.org/10.1007/s10495-026-02439-3#onco-edge-paper",
"url": "https://doi.org/10.1007/s10495-026-02439-3",
"title": "GLG1 in cancer-associated fibroblasts promotes bladder cancer growth while limiting tumor apoptosis.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and Ki-67.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"doi": "10.1007/s10495-026-02439-3",
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{
"id": "rna-seq",
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"name": "RNA sequencing & expression profiling",
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},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "mki67",
"kind": "target",
"name": "Ki-67",
"url": "https://onco.cc/targets/mki67/"
},
{
"id": "smad2",
"kind": "target",
"name": "SMAD2",
"url": "https://onco.cc/targets/smad2/"
},
{
"id": "hsp90b1",
"kind": "target",
"name": "HSP90B1",
"url": "https://onco.cc/targets/hsp90b1/"
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},
{
"id": "https://doi.org/10.1080/10255842.2026.2736274#onco-edge-paper",
"url": "https://doi.org/10.1080/10255842.2026.2736274",
"title": "Identification of anoikis-related and cell matrix adhesion genes in the progression of colon adenocarcinoma using bioinformatics analysis.",
"content_text": "Published in Comput Methods Biomech Biomed Engin on 23 September 2026; matched the OnCo record for SLC6A2.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
"precision": "day",
"venue": "Comput Methods Biomech Biomed Engin",
"doi": "10.1080/10255842.2026.2736274",
"records": [
{
"id": "slc6a2",
"kind": "target",
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},
{
"id": "https://doi.org/10.1136/rmdopen-2026-007198#onco-edge-paper",
"url": "https://doi.org/10.1136/rmdopen-2026-007198",
"title": "Integrated serum proteomics and autoantibody analyses reveal a biomarker signature predictive of flare during biologic tapering in rheumatoid arthritis.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics and SET.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"doi": "10.1136/rmdopen-2026-007198",
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{
"id": "proteomics",
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"name": "Proteomics & phosphoproteomics",
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{
"id": "set",
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},
{
"id": "https://doi.org/10.1021/acssensors.6c01933#onco-edge-paper",
"url": "https://doi.org/10.1021/acssensors.6c01933",
"title": "Isolation and Purification-Free Digital Single-Small Extracellular Vesicle Biosensing with Scalable Plasmonic Arrays.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Optical & fluorescence imaging, Liquid biopsy and MIR21.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"kind": "paper",
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"doi": "10.1021/acssensors.6c01933",
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{
"id": "optical-imaging",
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"name": "Optical & fluorescence imaging",
"url": "https://onco.cc/technologies/optical-imaging/"
},
{
"id": "liquid-biopsy",
"kind": "technology",
"name": "Liquid biopsy",
"url": "https://onco.cc/technologies/liquid-biopsy/"
},
{
"id": "mir21",
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"name": "MIR21",
"url": "https://onco.cc/targets/mir21/"
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},
{
"id": "https://doi.org/10.1177/03000605261488089#onco-edge-paper",
"url": "https://doi.org/10.1177/03000605261488089",
"title": "Multiomics analysis identifies <i>RNASET2</i> as a potential candidate target associated with lung adenocarcinoma.",
"content_text": "Published in J Int Med Res on 23 September 2026; matched the OnCo record for RNASET2.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
"precision": "day",
"venue": "J Int Med Res",
"doi": "10.1177/03000605261488089",
"records": [
{
"id": "rnaset2",
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"name": "RNASET2",
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}
},
{
"id": "https://doi.org/10.1007/s10142-026-02050-4#onco-edge-paper",
"url": "https://doi.org/10.1007/s10142-026-02050-4",
"title": "Mutations in untranslated non-coding regions of EGFR, AKT1 & HRAS modulate their expression regulatory networks to facilitate progression of colorectal cancer.",
"content_text": "Published in Funct Integr Genomics on 23 September 2026; matched the OnCo record for HRAS.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-23",
"precision": "day",
"venue": "Funct Integr Genomics",
"doi": "10.1007/s10142-026-02050-4",
"records": [
{
"id": "hras",
"kind": "target",
"name": "HRAS",
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},
{
"id": "https://doi.org/10.1073/pnas.2606222123#onco-edge-paper",
"url": "https://doi.org/10.1073/pnas.2606222123",
"title": "Neonatal enteric infection disrupts the microbiota-gut-brain axis through pattern recognition receptors and altered neuroimmune signaling.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched PSMC1.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"doi": "10.1073/pnas.2606222123",
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{
"id": "https://doi.org/10.1007/s11060-026-05806-x#onco-edge-paper",
"url": "https://doi.org/10.1007/s11060-026-05806-x",
"title": "nTMS-determined cortical excitability is associated with overall survival in patients with motor-eloquent glioblastoma.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched MGMT.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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{
"id": "https://doi.org/10.1126/sciadv.aeh9099#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aeh9099",
"title": "Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Topotecan, EGFR and Topoisomerase I.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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{
"id": "egfr",
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"name": "EGFR",
"url": "https://onco.cc/targets/egfr/"
},
{
"id": "top1",
"kind": "target",
"name": "Topoisomerase I",
"url": "https://onco.cc/targets/top1/"
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{
"id": "state-arc",
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{
"id": "https://doi.org/10.1126/sciadv.aeg3967#onco-edge-paper",
"url": "https://doi.org/10.1126/sciadv.aeg3967",
"title": "Structural mechanisms of SAMD9 autoinhibition and pathogenic dysregulation.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched SAMD9L and SAMD9.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"_onco": {
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{
"id": "https://doi.org/10.1113/jp290946#onco-edge-paper",
"url": "https://doi.org/10.1113/jp290946",
"title": "The influence of force on the encoding and perception of affective touch.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched CD96.",
"date_published": "2026-09-23T00:00:00Z",
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"_onco": {
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{
"id": "https://doi.org/10.1038/s41586-026-11050-0#onco-edge-paper",
"url": "https://doi.org/10.1038/s41586-026-11050-0",
"title": "The lipidomic architecture of the mouse brain.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Atlas and NBN.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
"paper"
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"_onco": {
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{
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},
{
"id": "https://doi.org/10.1186/s10020-026-01648-5#onco-edge-paper",
"url": "https://doi.org/10.1186/s10020-026-01648-5",
"title": "Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases.",
"content_text": "Published on 23 September 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics.",
"date_published": "2026-09-23T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
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},
{
"id": "https://doi.org/10.1200/jco-26-01914#onco-edge-paper",
"url": "https://doi.org/10.1200/jco-26-01914",
"title": "Bridging the Gap: From Molecular Residual Disease to Curative Opportunity: Circulating Tumor DNA-Guided Surveillance After Curative Resection for Stage I to III Colorectal Cancer.",
"content_text": "Published in J Clin Oncol on 16 September 2026; matched the OnCo record for Localised anal squamous cell carcinoma.",
"date_published": "2026-09-16T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-16",
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"venue": "J Clin Oncol",
"doi": "10.1200/jco-26-01914",
"records": [
{
"id": "localised-anal-cancer",
"kind": "cancer",
"name": "Localised anal squamous cell carcinoma",
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]
}
},
{
"id": "https://doi.org/10.1016/j.ccell.2026.08.012#onco-edge-paper",
"url": "https://doi.org/10.1016/j.ccell.2026.08.012",
"title": "Chemotherapy-free phase 1/2 trial of HRS-4642 plus adebrelimab in previously treated metastatic KRAS G12D-mutant pancreatic cancer.",
"content_text": "Published in Cancer Cell on 16 September 2026; matched the OnCo record for Adebrelimab.",
"date_published": "2026-09-16T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-16",
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"venue": "Cancer Cell",
"doi": "10.1016/j.ccell.2026.08.012",
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{
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{
"id": "https://doi.org/10.1200/jco-26-02254#onco-edge-paper",
"url": "https://doi.org/10.1200/jco-26-02254",
"title": "Erratum: Biomarker-Stratified Phase II Trial of Trastuzumab Rezetecan in Advanced Salivary Gland Carcinoma Across Cohorts With High and Low Human Epidermal Growth Factor Receptor 2 Expression.",
"content_text": "Published in J Clin Oncol on 16 September 2026; matched the OnCo record for Trastuzumab rezetecan.",
"date_published": "2026-09-16T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-16",
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"venue": "J Clin Oncol",
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{
"id": "trastuzumab-rezetecan",
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{
"id": "https://doi.org/10.1038/s41586-026-11055-9#onco-edge-paper",
"url": "https://doi.org/10.1038/s41586-026-11055-9",
"title": "Identification of broadly tumour-reactive γδ TCRs from multiple myeloma.",
"content_text": "Published in Nature on 16 September 2026; matched the OnCo record for HLA-C.",
"date_published": "2026-09-16T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-16",
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"venue": "Nature",
"doi": "10.1038/s41586-026-11055-9",
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"id": "https://doi.org/10.1038/s41586-026-11020-6#onco-edge-paper",
"url": "https://doi.org/10.1038/s41586-026-11020-6",
"title": "Mitochondrial fission factor senses and governs ferroptosis.",
"content_text": "Published in Nature on 16 September 2026; matched the OnCo record for PRKCB.",
"date_published": "2026-09-16T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-16",
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"venue": "Nature",
"doi": "10.1038/s41586-026-11020-6",
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{
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{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-sevabertinib-locally-advanced-or-metastatic-non-squamous-non-small#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-sevabertinib-locally-advanced-or-metastatic-non-squamous-non-small",
"title": "FDA grants accelerated approval to sevabertinib for locally advanced or metastatic non-squamous non-small cell lung cancer",
"content_text": "On September 9, 2026, the Food and Drug Administration granted accelerated approval to sevabertinib (Hyrnuo, Bayer Healthcare Pharmaceuticals Inc.), a kinase inhibitor, for adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain (TKD) activating mutations, as detected by an FDA-authorized test.",
"date_published": "2026-09-09T00:00:00Z",
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"_onco": {
"kind": "approval",
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"venue": "FDA",
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{
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{
"id": "lung-cancer",
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{
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{
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{
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{
"id": "https://doi.org/10.1371/journal.pcbi.1013101#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pcbi.1013101",
"title": "A physiology-based mathematical model of the renin-angiotensin system, bone remodeling, and calcium homeostasis: Effects of estrogen and renin-angiotensin system inhibitors.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched Mathematical models of cancer.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"doi": "10.1371/journal.pcbi.1013101",
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{
"id": "https://doi.org/10.1016/j.jbc.2026.113588#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jbc.2026.113588",
"title": "A prostate cancer-specific super-enhancer at 1q42.3 regulates the CAPN2 and KRT19.",
"content_text": "Published in J Biol Chem on 22 September 2026; matched the OnCo record for ETV5.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "J Biol Chem",
"doi": "10.1016/j.jbc.2026.113588",
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{
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{
"id": "https://doi.org/10.1016/j.celrep.2026.118033#onco-edge-paper",
"url": "https://doi.org/10.1016/j.celrep.2026.118033",
"title": "A USP28-BRD4 axis contributes to the acceleration of breast cancer growth by hyperglycemia.",
"content_text": "Published in Cell Rep on 22 September 2026; matched the OnCo record for USP28.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Cell Rep",
"doi": "10.1016/j.celrep.2026.118033",
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{
"id": "usp28",
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{
"id": "https://doi.org/10.1016/j.jbc.2026.113591#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jbc.2026.113591",
"title": "Activation-induced cytidine deaminase sustains glycolytic flux through MYST1 acetyltransferase-dependent lactylation in hepatocellular carcinoma.",
"content_text": "Published in J Biol Chem on 22 September 2026; matched the OnCo record for CDA.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "J Biol Chem",
"doi": "10.1016/j.jbc.2026.113591",
"records": [
{
"id": "cda",
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"name": "CDA",
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{
"id": "https://doi.org/10.2196/88672#onco-edge-paper",
"url": "https://doi.org/10.2196/88672",
"title": "Application of aiAtlas Version 1.2 to Simulate Variant Gene Function Restoration and Rescue Thresholds in Rare Diseases: Validation Case Study.",
"content_text": "Published in JMIR Bioinform Biotechnol on 22 September 2026; matched the OnCo record for ERCC2.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "JMIR Bioinform Biotechnol",
"doi": "10.2196/88672",
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{
"id": "https://doi.org/10.1186/s12985-026-03303-1#onco-edge-paper",
"url": "https://doi.org/10.1186/s12985-026-03303-1",
"title": "Assessment of combined antiviral drug treatment against selected α-, β-, and γ-herpesviruses.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched Small-molecule kinase inhibitors, CDK4/6 inhibitors and Abemaciclib.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"doi": "10.1186/s12985-026-03303-1",
"records": [
{
"id": "kinase-inhibitors",
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"name": "Small-molecule kinase inhibitors",
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{
"id": "cdk46-inhibitor",
"kind": "technology",
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"url": "https://onco.cc/technologies/cdk46-inhibitor/"
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{
"id": "abemaciclib",
"kind": "drug",
"name": "Abemaciclib",
"url": "https://onco.cc/drugs/abemaciclib/"
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},
{
"id": "https://doi.org/10.1007/s11060-026-05804-z#onco-edge-paper",
"url": "https://doi.org/10.1007/s11060-026-05804-z",
"title": "BKCa channel deletion modulates the DNA damage response to electron ultra-high dose rate irradiation in glioblastoma cells.",
"content_text": "Published in J Neurooncol on 22 September 2026; matched the OnCo record for TP53BP1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "J Neurooncol",
"doi": "10.1007/s11060-026-05804-z",
"records": [
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{
"id": "https://doi.org/10.1080/22221751.2026.2732702#onco-edge-paper",
"url": "https://doi.org/10.1080/22221751.2026.2732702",
"title": "Breaking the deadlock of metallo-β-lactamases: evidence and prospects for Aztreonam/Avibactam.",
"content_text": "Published in Emerg Microbes Infect on 22 September 2026; matched the OnCo record for ATM.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Emerg Microbes Infect",
"doi": "10.1080/22221751.2026.2732702",
"records": [
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{
"id": "https://doi.org/10.1016/j.tranon.2026.103048#onco-edge-paper",
"url": "https://doi.org/10.1016/j.tranon.2026.103048",
"title": "Calcitriol alleviates ARID2-deficient gastric cancer metastasis via inhibition of the Wnt/β-catenin signaling pathway.",
"content_text": "Published in Transl Oncol on 22 September 2026; matched the OnCo record for ARID2.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Transl Oncol",
"doi": "10.1016/j.tranon.2026.103048",
"records": [
{
"id": "arid2",
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{
"id": "https://doi.org/10.1371/journal.pgph.0007122#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pgph.0007122",
"title": "Cost and cost-effectiveness of alternative screening and diagnostic pathways for achieving hepatitis C elimination in the country of Georgia.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched Abiraterone acetate, Docetaxel and Leucovorin.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
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"id": "abiraterone",
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{
"id": "docetaxel",
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{
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{
"id": "https://doi.org/10.1007/s10928-026-10061-8#onco-edge-paper",
"url": "https://doi.org/10.1007/s10928-026-10061-8",
"title": "Development of an isavuconazole physiologically-based pharmacokinetic model for adult and pediatric populations.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched Azacitidine, Decitabine + cedazuridine and MAX.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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{
"id": "decitabine-cedazuridine",
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{
"id": "https://doi.org/10.1016/j.kint.2026.07.035#onco-edge-paper",
"url": "https://doi.org/10.1016/j.kint.2026.07.035",
"title": "Donor and recipient immune programs underlying delayed graft function in kidney transplantation revealed by temporal single-cell profiling.",
"content_text": "Published in Kidney Int on 22 September 2026; matched the OnCo record for AREG.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"date": "2026-09-22",
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"venue": "Kidney Int",
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{
"id": "https://doi.org/10.1073/pnas.2603770123#onco-edge-paper",
"url": "https://doi.org/10.1073/pnas.2603770123",
"title": "Dynamic remodeling of the transcriptional landscape drives Merkel cell specification and mechanosensory differentiation.",
"content_text": "Published in Proc Natl Acad Sci U S A on 22 September 2026; matched the OnCo record for TUBB3.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"date": "2026-09-22",
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"venue": "Proc Natl Acad Sci U S A",
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{
"id": "https://doi.org/10.1007/s12194-026-01144-9#onco-edge-paper",
"url": "https://doi.org/10.1007/s12194-026-01144-9",
"title": "Evaluation of the image quality index with MRI motion artifacts on tumor segmentation using deep learning.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched MRI.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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{
"id": "https://doi.org/10.1186/s43556-026-00588-0#onco-edge-paper",
"url": "https://doi.org/10.1186/s43556-026-00588-0",
"title": "Fine-tuning the lysine-arginine duet: a dietary approach to suppress tumor growth.",
"content_text": "Published in Mol Biomed on 22 September 2026; matched the OnCo record for HBB.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
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"date": "2026-09-22",
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"venue": "Mol Biomed",
"doi": "10.1186/s43556-026-00588-0",
"records": [
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{
"id": "https://doi.org/10.1080/15257770.2026.2735915#onco-edge-paper",
"url": "https://doi.org/10.1080/15257770.2026.2735915",
"title": "From genomic instability to epigenetic regulation: the role of DNA repair gene variants and non-coding RNAs in colorectal carcinogenesis.",
"content_text": "Published in Nucleosides Nucleotides Nucleic Acids on 22 September 2026; matched the OnCo record for ERCC1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Nucleosides Nucleotides Nucleic Acids",
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{
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"url": "https://doi.org/10.1016/j.tranon.2026.103040",
"title": "Genetic evaluation of encorafenib-associated kinases RAF1 and MAPK8 in pancreatic cancer: Exploratory mediation by circulating immune traits.",
"content_text": "Published in Transl Oncol on 22 September 2026; matched the OnCo record for MAPK8.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Transl Oncol",
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{
"id": "https://doi.org/10.1080/2162402x.2026.2736333#onco-edge-paper",
"url": "https://doi.org/10.1080/2162402x.2026.2736333",
"title": "IL-15 trans-presentation at the innate-adaptive interface: mechanisms and translation in cancer immunotherapy.",
"content_text": "Published in Oncoimmunology on 22 September 2026; matched the OnCo record for IL2RB.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Oncoimmunology",
"doi": "10.1080/2162402x.2026.2736333",
"records": [
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"name": "IL2RB",
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{
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{
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{
"id": "https://doi.org/10.1007/s00401-026-03089-0#onco-edge-paper",
"url": "https://doi.org/10.1007/s00401-026-03089-0",
"title": "Integrated multi-omics identifies lineage-dependent myeloid cells recruitment and the APP-CD74 axis as an immunoregulatory target in pediatric high-grade glioma.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and State.",
"date_published": "2026-09-22T00:00:00Z",
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"_onco": {
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{
"id": "https://doi.org/10.1016/j.mce.2026.112924#onco-edge-paper",
"url": "https://doi.org/10.1016/j.mce.2026.112924",
"title": "Integrative Genetic Analyses Identify Mitochondrial-Related Genes Associated With Female Reproductive Disorders.",
"content_text": "Published in Mol Cell Endocrinol on 22 September 2026; matched the OnCo record for ALDH2.",
"date_published": "2026-09-22T00:00:00Z",
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"_onco": {
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{
"id": "https://doi.org/10.1016/j.ygeno.2026.111324#onco-edge-paper",
"url": "https://doi.org/10.1016/j.ygeno.2026.111324",
"title": "Integrative profiling of multi-modal plasma cfRNA signatures enables detection and prognostic risk stratification in breast cancer.",
"content_text": "Published in Genomics on 22 September 2026; matched the OnCo record for DLST.",
"date_published": "2026-09-22T00:00:00Z",
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Genomics",
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"title": "Ki-67 expression and rates of pathologic complete response in T1cN0M0 triple-negative breast cancer: a national cancer database analysis.",
"content_text": "Published in Breast Cancer Res Treat on 22 September 2026; matched the OnCo record for Invasive lobular carcinoma of the breast.",
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"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Breast Cancer Res Treat",
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{
"id": "invasive-lobular-carcinoma",
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{
"id": "https://doi.org/10.1007/s12105-026-01967-3#onco-edge-paper",
"url": "https://doi.org/10.1007/s12105-026-01967-3",
"title": "Low-Grade Salivary Myoepithelial Carcinoma of the Upper Lip Harboring a Novel CARMN/miR143HG::PLAG1 Fusion.",
"content_text": "Published in Head Neck Pathol on 22 September 2026; matched the OnCo record for PLAG1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"venue": "Head Neck Pathol",
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{
"id": "https://doi.org/10.3724/abbs.2026109#onco-edge-paper",
"url": "https://doi.org/10.3724/abbs.2026109",
"title": "Midazolam suppresses glioma progression by attenuating neuronal activity and downregulating IGF1 signaling.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, AKT and Ki-67.",
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"id": "akt",
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{
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{
"id": "https://doi.org/10.1080/15257770.2026.2733331#onco-edge-paper",
"url": "https://doi.org/10.1080/15257770.2026.2733331",
"title": "miR-324-5p acts as an independent prognostic biomarker and inhibits pediatric medulloblastoma progression by targeting HOXA9.",
"content_text": "Published in Nucleosides Nucleotides Nucleic Acids on 22 September 2026; matched the OnCo record for HOXA9.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Nucleosides Nucleotides Nucleic Acids",
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{
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{
"id": "https://doi.org/10.1016/j.jhepr.2026.102042#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jhepr.2026.102042",
"title": "Modeling Liver Cancer Molecular and Histological Features by CRISPR Editing of Porcine Hepatocytes.",
"content_text": "Published in JHEP Rep on 22 September 2026; matched the OnCo record for AXIN1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "JHEP Rep",
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{
"id": "https://doi.org/10.1080/2162402x.2026.2736339#onco-edge-paper",
"url": "https://doi.org/10.1080/2162402x.2026.2736339",
"title": "Modular mRNA cocktail enables synergistic activation of antigen-specific T cells for cancer immunotherapy.",
"content_text": "Published in Oncoimmunology on 22 September 2026; matched the OnCo record for CD80.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
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"venue": "Oncoimmunology",
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{
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{
"id": "https://doi.org/10.1172/jci.insight.209036#onco-edge-paper",
"url": "https://doi.org/10.1172/jci.insight.209036",
"title": "Molecular underpinnings of metastatic small renal masses.",
"content_text": "Published in JCI Insight on 22 September 2026; matched the OnCo record for SRMS.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "JCI Insight",
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{
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{
"id": "https://doi.org/10.1016/j.bbadis.2026.168473#onco-edge-paper",
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"title": "Obesity associated elevated leptin might contribute to paclitaxel resistance via PLCB1/IP3R1 axis in head and neck cancers.",
"content_text": "Published in Biochim Biophys Acta Mol Basis Dis on 22 September 2026; matched the OnCo record for ITPR1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "Biochim Biophys Acta Mol Basis Dis",
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{
"id": "https://doi.org/10.1371/journal.pcbi.1014041#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pcbi.1014041",
"title": "OT-knn: A neighborhood-aware optimal transport framework for aligning spatial transcriptomics data.",
"content_text": "Published on 22 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling and Spatial transcriptomics.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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{
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{
"id": "https://doi.org/10.1159/dne/aclag006#onco-edge-paper",
"url": "https://doi.org/10.1159/dne/aclag006",
"title": "Peripheral biomarkers of anxiety in autism and attention deficit/hyperactivity disorder.",
"content_text": "Published in Dev Neurosci on 22 September 2026; matched the OnCo record for CX3CL1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
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"venue": "Dev Neurosci",
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{
"id": "https://doi.org/10.1038/s41417-026-01083-y#onco-edge-paper",
"url": "https://doi.org/10.1038/s41417-026-01083-y",
"title": "POLE2 of tumor cells promotes OPN secretion based on PCLAF to drive M2 macrophage polarization in clear cell renal cell carcinoma.",
"content_text": "Published in Cancer Gene Ther on 22 September 2026; matched the OnCo record for NFATC2.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "Cancer Gene Ther",
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"records": [
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{
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"title": "Predictive molecular signatures for successful tapering of canakinumab in systemic juvenile idiopathic arthritis.",
"content_text": "Published in Ann Rheum Dis on 22 September 2026; matched the OnCo record for BCL6.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "Ann Rheum Dis",
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"records": [
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{
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{
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{
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"url": "https://doi.org/10.7554/elife.101386",
"title": "PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development.",
"content_text": "Published in Elife on 22 September 2026; matched the OnCo record for SFPQ.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "Elife",
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{
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"title": "Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma.",
"content_text": "Published in Mol Med on 22 September 2026; matched the OnCo record for HDAC5.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Mol Med",
"doi": "10.1186/s10020-026-01652-9",
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{
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"title": "Real-world data from patients treated with chemotherapy for biliary tract cancer: insights from a prognostic model. ☆.",
"content_text": "Published in JHEP Rep on 22 September 2026; matched the OnCo record for PSEN2.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"date": "2026-09-22",
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"venue": "JHEP Rep",
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{
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{
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"url": "https://doi.org/10.1038/s41416-026-03615-7",
"title": "Reproductive factors and the expression of stromal markers in benign breast biopsy samples.",
"content_text": "Published in Br J Cancer on 22 September 2026; matched the OnCo record for TNC.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Br J Cancer",
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"records": [
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{
"id": "https://doi.org/10.1172/jci.insight.204032#onco-edge-paper",
"url": "https://doi.org/10.1172/jci.insight.204032",
"title": "Right ventricular pressure overload disturbs T-tubule maturation via MEF2D's transcriptional regulation of BIN1.",
"content_text": "Published in JCI Insight on 22 September 2026; matched the OnCo record for MEF2D.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "JCI Insight",
"doi": "10.1172/jci.insight.204032",
"records": [
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{
"id": "https://doi.org/10.3791/73188#onco-edge-paper",
"url": "https://doi.org/10.3791/73188",
"title": "Role of the miR-1298/Bone Morphogenetic Protein 7 Axis in Colorectal Cancer.",
"content_text": "Published in J Vis Exp on 22 September 2026; matched the OnCo record for BMP7.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"date": "2026-09-22",
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"venue": "J Vis Exp",
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{
"id": "https://doi.org/10.1016/j.celrep.2026.118013#onco-edge-paper",
"url": "https://doi.org/10.1016/j.celrep.2026.118013",
"title": "SDCBP competes with CBL to stabilize PES1 and promote c-Myc translation in ESCC tumorigenesis.",
"content_text": "Published in Cell Rep on 22 September 2026; matched the OnCo record for CBL.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Cell Rep",
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"records": [
{
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{
"id": "https://doi.org/10.1007/s00383-026-06590-5#onco-edge-paper",
"url": "https://doi.org/10.1007/s00383-026-06590-5",
"title": "Semi-automated erythema quantification in infantile haemangioma receiving propranolol: a pilot feasibility study.",
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"_onco": {
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{
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"title": "Spatiotemporally controlled degradation of CDK6 <i>via</i> light-triggered ROS generation: uncovering the proximity effect-mediated dual target depletion.",
"content_text": "Published in Org Biomol Chem on 22 September 2026; matched the OnCo record for CCND3.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "Org Biomol Chem",
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{
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"title": "Structural and functional divergence of cancer hotspot mutations in CREBBP.",
"content_text": "Published in Proc Natl Acad Sci U S A on 22 September 2026; matched the OnCo record for CREBBP.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Proc Natl Acad Sci U S A",
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{
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"url": "https://doi.org/10.1042/bcj20260584",
"title": "Structural organization of TAM receptor ectodomains.",
"content_text": "Published in Biochem J on 22 September 2026; matched the OnCo record for MERTK.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Biochem J",
"doi": "10.1042/bcj20260584",
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{
"id": "mertk",
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{
"id": "https://doi.org/10.1515/jpem-2026-0398#onco-edge-paper",
"url": "https://doi.org/10.1515/jpem-2026-0398",
"title": "Successful management of paediatric chronic SIAD with oral urea: report of two cases.",
"content_text": "Published in J Pediatr Endocrinol Metab on 22 September 2026; matched the OnCo record for Paediatric low-grade glioma.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "J Pediatr Endocrinol Metab",
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"records": [
{
"id": "paediatric-low-grade-glioma",
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},
{
"id": "https://doi.org/10.1002/path.70133#onco-edge-paper",
"url": "https://doi.org/10.1002/path.70133",
"title": "Targeting PPP1R14B overcomes immunotherapy resistance in prostate cancer by restoring CD8+ T-cell infiltration via the Nrf2/CX3CL1 axis.",
"content_text": "Published in J Pathol on 22 September 2026; matched the OnCo record for CX3CL1.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "J Pathol",
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{
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{
"id": "https://doi.org/10.1093/g3journal/jkag265#onco-edge-paper",
"url": "https://doi.org/10.1093/g3journal/jkag265",
"title": "The Drosophila FET ortholog Cabeza is an essential cofactor for ETV4-mediated activation of GGAA microsatellite neoenhancers.",
"content_text": "Published in G3 (Bethesda) on 22 September 2026; matched the OnCo record for ETV4.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "G3 (Bethesda)",
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{
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{
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},
{
"id": "https://doi.org/10.1016/j.patol.2026.100899#onco-edge-paper",
"url": "https://doi.org/10.1016/j.patol.2026.100899",
"title": "The pathological significance of DNA damage-inducible transcript 3 immunohistochemistry in the diagnosis of myxoid liposarcoma.",
"content_text": "Published in Rev Esp Patol on 22 September 2026; matched the OnCo record for DDIT3.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
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"venue": "Rev Esp Patol",
"doi": "10.1016/j.patol.2026.100899",
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{
"id": "ddit3",
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{
"id": "https://doi.org/10.1007/s00508-026-02821-w#onco-edge-paper",
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"title": "Tumor-induced osteomalacia caused by fibroblast growth factor 23 excess : Delayed diagnosis resulting from overlooked hypophosphatemia-A case report.",
"content_text": "Published in Wien Klin Wochenschr on 22 September 2026; matched the OnCo record for FGF23.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Wien Klin Wochenschr",
"doi": "10.1007/s00508-026-02821-w",
"records": [
{
"id": "fgf23",
"kind": "target",
"name": "FGF23",
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},
{
"id": "https://doi.org/10.1111/trf.70401#onco-edge-paper",
"url": "https://doi.org/10.1111/trf.70401",
"title": "Unexpected neonatal ABO discrepancy revealing ABO*cisAB.05 during routine cord blood testing.",
"content_text": "Published in Transfusion on 22 September 2026; matched the OnCo record for ABO.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Transfusion",
"doi": "10.1111/trf.70401",
"records": [
{
"id": "abo",
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},
{
"id": "https://doi.org/10.1177/10668969261457884#onco-edge-paper",
"url": "https://doi.org/10.1177/10668969261457884",
"title": "Uterine Tumor Resembling Ovarian Sex Cord Tumor With <i>GREB1::NCOA2</i> Fusion and Neuroendocrine Marker Expression: A Case Report and Literature Review.",
"content_text": "Published in Int J Surg Pathol on 22 September 2026; matched the OnCo record for NCOA2.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "Int J Surg Pathol",
"doi": "10.1177/10668969261457884",
"records": [
{
"id": "ncoa2",
"kind": "target",
"name": "NCOA2",
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{
"id": "https://doi.org/10.1038/s44319-026-00934-x#onco-edge-paper",
"url": "https://doi.org/10.1038/s44319-026-00934-x",
"title": "VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease.",
"content_text": "Published in EMBO Rep on 22 September 2026; matched the OnCo record for CEBPA.",
"date_published": "2026-09-22T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-22",
"precision": "day",
"venue": "EMBO Rep",
"doi": "10.1038/s44319-026-00934-x",
"records": [
{
"id": "cebpa",
"kind": "target",
"name": "CEBPA",
"url": "https://onco.cc/targets/cebpa/"
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{
"id": "https://doi.org/10.1038/s41586-026-11137-8#onco-edge-paper",
"url": "https://doi.org/10.1038/s41586-026-11137-8",
"title": "Author Correction: Erythropoietin receptor on cDC1s dictates immune tolerance.",
"content_text": "Published in Nature on 15 September 2026; matched the OnCo record for Erythropoietin receptor.",
"date_published": "2026-09-15T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-15",
"precision": "day",
"venue": "Nature",
"doi": "10.1038/s41586-026-11137-8",
"records": [
{
"id": "epor",
"kind": "target",
"name": "Erythropoietin receptor",
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},
{
"id": "https://doi.org/10.1200/jco-26-00285#onco-edge-paper",
"url": "https://doi.org/10.1200/jco-26-00285",
"title": "Circulating Tumor DNA Profiling Defines Risk Classification in Patients With Ewing Sarcoma: A Report From the Children's Oncology Group and the LEOPARD Study.",
"content_text": "Published in J Clin Oncol on 15 September 2026; matched the OnCo record for STAG2.",
"date_published": "2026-09-15T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-15",
"precision": "day",
"venue": "J Clin Oncol",
"doi": "10.1200/jco-26-00285",
"records": [
{
"id": "stag2",
"kind": "target",
"name": "STAG2",
"url": "https://onco.cc/targets/stag2/"
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{
"id": "https://doi.org/10.1038/s41591-026-04559-4#onco-edge-paper",
"url": "https://doi.org/10.1038/s41591-026-04559-4",
"title": "Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRAS<sup>G12D</sup> mutations: a phase 1 trial.",
"content_text": "Published in Nat Med on 15 September 2026; matched the OnCo record for GFH375.",
"date_published": "2026-09-15T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-15",
"precision": "day",
"venue": "Nat Med",
"doi": "10.1038/s41591-026-04559-4",
"records": [
{
"id": "gfh375",
"kind": "drug",
"name": "GFH375",
"url": "https://onco.cc/drugs/gfh375/"
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]
}
},
{
"id": "https://doi.org/10.1158/2159-8290.cd-26-0447#onco-edge-paper",
"url": "https://doi.org/10.1158/2159-8290.cd-26-0447",
"title": "Targeting BLVRB Overcomes Immunosuppression and Potentiates Immunotherapy in Monocytic Acute Myeloid Leukemia.",
"content_text": "Published in Cancer Discov on 15 September 2026; matched the OnCo record for MAFB.",
"date_published": "2026-09-15T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-15",
"precision": "day",
"venue": "Cancer Discov",
"doi": "10.1158/2159-8290.cd-26-0447",
"records": [
{
"id": "mafb",
"kind": "target",
"name": "MAFB",
"url": "https://onco.cc/targets/mafb/"
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{
"id": "https://doi.org/10.1002/fsn3.72380#onco-edge-paper",
"url": "https://doi.org/10.1002/fsn3.72380",
"title": "<i>Citrus reticulata</i> Essential Oil as a Bioactive Food Ingredient: Composition Variability, Extraction, Functional Bioactivities, and Cross-Study Quantitative Analysis.",
"content_text": "Published in Food Sci Nutr on 21 September 2026; found by the roadmap watch for CROSS.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Food Sci Nutr",
"doi": "10.1002/fsn3.72380",
"records": [
{
"id": "cross",
"kind": "trial",
"name": "CROSS",
"url": "https://onco.cc/trials/cross/"
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{
"id": "chemotherapy-roadmap",
"kind": "roadmap",
"name": "Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs",
"url": "https://onco.cc/roadmaps/chemotherapy-roadmap/"
},
{
"id": "radiation-roadmap",
"kind": "roadmap",
"name": "Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH",
"url": "https://onco.cc/roadmaps/radiation-roadmap/"
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]
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},
{
"id": "https://doi.org/10.1158/2643-3230.bcd-26-0115#onco-edge-paper",
"url": "https://doi.org/10.1158/2643-3230.bcd-26-0115",
"title": "A Phase I/II Trial of Anti-CD22/CD19 CAR-T Cell Therapy, CART2219.1, in Adult and Pediatric Relapsed/Refractory B-ALL.",
"content_text": "Published in Blood Cancer Discov on 21 September 2026; matched the OnCo record for Acute lymphoblastic leukaemia.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Blood Cancer Discov",
"doi": "10.1158/2643-3230.bcd-26-0115",
"records": [
{
"id": "all-leukemia",
"kind": "cancer",
"name": "Acute lymphoblastic leukaemia",
"url": "https://onco.cc/cancers/all-leukemia/"
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{
"id": "bach2",
"kind": "target",
"name": "BACH2",
"url": "https://onco.cc/targets/bach2/"
},
{
"id": "cd22",
"kind": "target",
"name": "CD22",
"url": "https://onco.cc/targets/cd22/"
},
{
"id": "lef1",
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"url": "https://onco.cc/targets/lef1/"
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{
"id": "https://doi.org/10.1523/eneuro.0017-26.2026#onco-edge-paper",
"url": "https://doi.org/10.1523/eneuro.0017-26.2026",
"title": "An Allometric Approach to Fine-Mapping Subcortical Volume Alterations in RASopathies.",
"content_text": "Published in eNeuro on 21 September 2026; matched the OnCo record for SOS1.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "eNeuro",
"doi": "10.1523/eneuro.0017-26.2026",
"records": [
{
"id": "sos1",
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]
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{
"id": "https://doi.org/10.1016/j.kint.2026.07.038#onco-edge-paper",
"url": "https://doi.org/10.1016/j.kint.2026.07.038",
"title": "Androgens Drive SOX9 Upregulation in Injured Proximal Tubular Cells.",
"content_text": "Published in Kidney Int on 21 September 2026; matched the OnCo record for SOX9.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Kidney Int",
"doi": "10.1016/j.kint.2026.07.038",
"records": [
{
"id": "sox9",
"kind": "target",
"name": "SOX9",
"url": "https://onco.cc/targets/sox9/"
},
{
"id": "cisplatin",
"kind": "drug",
"name": "Cisplatin",
"url": "https://onco.cc/drugs/cisplatin/"
},
{
"id": "platinum",
"kind": "technology",
"name": "Platinum agents",
"url": "https://onco.cc/technologies/platinum/"
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{
"id": "androgen-receptor",
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"url": "https://onco.cc/targets/androgen-receptor/"
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},
{
"id": "https://doi.org/10.1002/mus.70404#onco-edge-paper",
"url": "https://doi.org/10.1002/mus.70404",
"title": "Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy.",
"content_text": "Published in Muscle Nerve on 21 September 2026; matched the OnCo record for Small intestine cancer.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Muscle Nerve",
"doi": "10.1002/mus.70404",
"records": [
{
"id": "small-bowel",
"kind": "cancer",
"name": "Small intestine cancer",
"url": "https://onco.cc/cancers/small-bowel/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41392-026-02870-7#onco-edge-paper",
"url": "https://doi.org/10.1038/s41392-026-02870-7",
"title": "BCLX<sub>L</sub> blockade rewires cell fate to overcome PARP inhibitor resistance in ovarian cancer.",
"content_text": "Published in Signal Transduct Target Ther on 21 September 2026; matched the OnCo record for BIM.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Signal Transduct Target Ther",
"doi": "10.1038/s41392-026-02870-7",
"records": [
{
"id": "bim",
"kind": "target",
"name": "BIM",
"url": "https://onco.cc/targets/bim/"
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}
},
{
"id": "https://doi.org/10.1007/s13205-026-05065-7#onco-edge-paper",
"url": "https://doi.org/10.1007/s13205-026-05065-7",
"title": "Carmofur inhibits ovarian cancer cell proliferation, migration, and invasion via disrupting the YAP-1/TEAD pathway: in vitro and in silico approaches.",
"content_text": "Published in 3 Biotech on 21 September 2026; matched the OnCo record for YAP1.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "3 Biotech",
"doi": "10.1007/s13205-026-05065-7",
"records": [
{
"id": "yap1",
"kind": "target",
"name": "YAP1",
"url": "https://onco.cc/targets/yap1/"
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},
{
"id": "https://doi.org/10.1016/j.tranon.2026.103045#onco-edge-paper",
"url": "https://doi.org/10.1016/j.tranon.2026.103045",
"title": "CD36 links fatty acid metabolism to tumor immune microenvironment remodeling in breast cancer.",
"content_text": "Published in Transl Oncol on 21 September 2026; matched the OnCo record for FGA.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Transl Oncol",
"doi": "10.1016/j.tranon.2026.103045",
"records": [
{
"id": "fga",
"kind": "target",
"name": "FGA",
"url": "https://onco.cc/targets/fga/"
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]
}
},
{
"id": "https://doi.org/10.3390/reports9030318#onco-edge-paper",
"url": "https://doi.org/10.3390/reports9030318",
"title": "Chemotherapy-Free Polatuzumab Vedotin and Rituximab (Pola-R) for Frail, Older Patients with Relapsed DLBCL: A Case for Geriatric Assessment and Shared Decision-Making.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Rituximab, Polatuzumab vedotin and Cytotoxic chemotherapy.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.3390/reports9030318",
"records": [
{
"id": "rituximab",
"kind": "drug",
"name": "Rituximab",
"url": "https://onco.cc/drugs/rituximab/"
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{
"id": "polatuzumab-vedotin",
"kind": "drug",
"name": "Polatuzumab vedotin",
"url": "https://onco.cc/drugs/polatuzumab-vedotin/"
},
{
"id": "cytotoxic-chemotherapy",
"kind": "technology",
"name": "Cytotoxic chemotherapy",
"url": "https://onco.cc/technologies/cytotoxic-chemotherapy/"
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{
"id": "geriatric-assessment",
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{
"id": "https://doi.org/10.1097/cji.0000000000000622#onco-edge-paper",
"url": "https://doi.org/10.1097/cji.0000000000000622",
"title": "Clinical Features, Treatment, and Outcomes of Sintilimab-induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.",
"content_text": "Published in J Immunother on 21 September 2026; matched the OnCo record for Human normal immunoglobulin.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "J Immunother",
"doi": "10.1097/cji.0000000000000622",
"records": [
{
"id": "human-normal-immunoglobulin",
"kind": "drug",
"name": "Human normal immunoglobulin",
"url": "https://onco.cc/drugs/human-normal-immunoglobulin/"
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]
}
},
{
"id": "https://doi.org/10.1038/s41378-026-01420-z#onco-edge-paper",
"url": "https://doi.org/10.1038/s41378-026-01420-z",
"title": "Code-multiplexed multi-frequency impedance cytometry with a unified deep-unfolding network.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.1038/s41378-026-01420-z",
"records": [
{
"id": "single-cell-spatial",
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"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
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]
}
},
{
"id": "https://doi.org/10.1016/j.bcp.2026.118492#onco-edge-paper",
"url": "https://doi.org/10.1016/j.bcp.2026.118492",
"title": "Combination pharmacotherapy for MASH: Potential synergistic approaches.",
"content_text": "Published in Biochem Pharmacol on 21 September 2026; matched the OnCo record for THRB.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Biochem Pharmacol",
"doi": "10.1016/j.bcp.2026.118492",
"records": [
{
"id": "thrb",
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"name": "THRB",
"url": "https://onco.cc/targets/thrb/"
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}
},
{
"id": "https://doi.org/10.1002/1545-5017.70678#onco-edge-paper",
"url": "https://doi.org/10.1002/1545-5017.70678",
"title": "Comparative Effectiveness of Antibiotic Prophylaxis Regimens in Pediatric Acute Myeloid Leukemia.",
"content_text": "Published in Pediatr Blood Cancer on 21 September 2026; matched the OnCo record for Acute myeloid leukaemia in children.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Pediatr Blood Cancer",
"doi": "10.1002/1545-5017.70678",
"records": [
{
"id": "aml-paediatric",
"kind": "cancer",
"name": "Acute myeloid leukaemia in children",
"url": "https://onco.cc/cancers/aml-paediatric/"
}
]
}
},
{
"id": "https://doi.org/10.7554/elife.113186#onco-edge-paper",
"url": "https://doi.org/10.7554/elife.113186",
"title": "Correction: Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis.",
"content_text": "Published in Elife on 21 September 2026; matched the OnCo record for LMO2.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Elife",
"doi": "10.7554/elife.113186",
"records": [
{
"id": "lmo2",
"kind": "target",
"name": "LMO2",
"url": "https://onco.cc/targets/lmo2/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s10616-026-01069-6#onco-edge-paper",
"url": "https://doi.org/10.1007/s10616-026-01069-6",
"title": "Deciphering the apoptotic properties of ergolide, a sesquiterpene lactone form <i>Inula oculus-christi</i>, in hepatocellular carcinoma.",
"content_text": "Published in Cytotechnology on 21 September 2026; matched the OnCo record for CASP8.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Cytotechnology",
"doi": "10.1007/s10616-026-01069-6",
"records": [
{
"id": "casp8",
"kind": "target",
"name": "CASP8",
"url": "https://onco.cc/targets/casp8/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41590-026-02655-8#onco-edge-paper",
"url": "https://doi.org/10.1038/s41590-026-02655-8",
"title": "Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and IRF4.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.1038/s41590-026-02655-8",
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{
"id": "rna-seq",
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"name": "RNA sequencing & expression profiling",
"url": "https://onco.cc/technologies/rna-seq/"
},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
},
{
"id": "irf4",
"kind": "target",
"name": "IRF4",
"url": "https://onco.cc/targets/irf4/"
},
{
"id": "jun",
"kind": "target",
"name": "JUN",
"url": "https://onco.cc/targets/jun/"
},
{
"id": "fos",
"kind": "target",
"name": "FOS",
"url": "https://onco.cc/targets/fos/"
},
{
"id": "fosb",
"kind": "target",
"name": "FOSB",
"url": "https://onco.cc/targets/fosb/"
}
]
}
},
{
"id": "https://doi.org/10.1080/13814788.2026.2729221#onco-edge-paper",
"url": "https://doi.org/10.1080/13814788.2026.2729221",
"title": "Discrepancies in low-value practices across cardiovascular disease prevention guidelines. A narrative review.",
"content_text": "Published in Eur J Gen Pract on 21 September 2026; matched the OnCo record for LPA.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Eur J Gen Pract",
"doi": "10.1080/13814788.2026.2729221",
"records": [
{
"id": "lpa",
"kind": "target",
"name": "LPA",
"url": "https://onco.cc/targets/lpa/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.cptl.2026.102799#onco-edge-paper",
"url": "https://doi.org/10.1016/j.cptl.2026.102799",
"title": "Disease-state-themed escape room simulations in undergraduate pharmacy education: A systematic review.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched MET, Med-Gemini and MedLM and State.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.1016/j.cptl.2026.102799",
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{
"id": "met",
"kind": "target",
"name": "MET",
"url": "https://onco.cc/targets/met/"
},
{
"id": "med-gemini",
"kind": "technology",
"name": "Med-Gemini and MedLM",
"url": "https://onco.cc/technologies/med-gemini/"
},
{
"id": "state-arc",
"kind": "technology",
"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
}
]
}
},
{
"id": "https://doi.org/10.1111/jop.70186#onco-edge-paper",
"url": "https://doi.org/10.1111/jop.70186",
"title": "Effects of Infrared and Dual-Wavelength Photobiomodulation Therapy on Mandibular Bone Healing Following Radiotherapy and Tooth Extraction: An Experimental Study.",
"content_text": "Published in J Oral Pathol Med on 21 September 2026; matched the OnCo record for BMP2.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "J Oral Pathol Med",
"doi": "10.1111/jop.70186",
"records": [
{
"id": "bmp2",
"kind": "target",
"name": "BMP2",
"url": "https://onco.cc/targets/bmp2/"
}
]
}
},
{
"id": "https://doi.org/10.1530/vb-26-0007#onco-edge-paper",
"url": "https://doi.org/10.1530/vb-26-0007",
"title": "Endothelial Plasticity as a Continuum in the Tumor Microenvironment.",
"content_text": "Published in Vasc Biol on 21 September 2026; matched the OnCo record for TEC.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Vasc Biol",
"doi": "10.1530/vb-26-0007",
"records": [
{
"id": "tec",
"kind": "target",
"name": "TEC",
"url": "https://onco.cc/targets/tec/"
}
]
}
},
{
"id": "https://doi.org/10.1002/exp2.70222#onco-edge-paper",
"url": "https://doi.org/10.1002/exp2.70222",
"title": "ER-Localized Deadenylase <i>PNLDC1</i> Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of <i>TUBB4B</i>.",
"content_text": "Published in Exploration (Beijing) on 21 September 2026; matched the OnCo record for Mebendazole.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Exploration (Beijing)",
"doi": "10.1002/exp2.70222",
"records": [
{
"id": "mebendazole",
"kind": "drug",
"name": "Mebendazole",
"url": "https://onco.cc/drugs/mebendazole/"
},
{
"id": "tubb4b",
"kind": "target",
"name": "TUBB4B",
"url": "https://onco.cc/targets/tubb4b/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.isci.2026.117507#onco-edge-paper",
"url": "https://doi.org/10.1016/j.isci.2026.117507",
"title": "Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Mirdametinib and MEK1/2.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"doi": "10.1016/j.isci.2026.117507",
"records": [
{
"id": "mirdametinib",
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"name": "Mirdametinib",
"url": "https://onco.cc/drugs/mirdametinib/"
},
{
"id": "mek",
"kind": "target",
"name": "MEK1/2",
"url": "https://onco.cc/targets/mek/"
}
]
}
},
{
"id": "https://doi.org/10.3390/biology15181672#onco-edge-paper",
"url": "https://doi.org/10.3390/biology15181672",
"title": "Exercise and Intestinal Barrier Integrity: Molecular Mechanisms and Therapeutic Potential in Gut Health and Disease.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched NFE2L2.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"doi": "10.3390/biology15181672",
"records": [
{
"id": "nfe2l2",
"kind": "target",
"name": "NFE2L2",
"url": "https://onco.cc/targets/nfe2l2/"
}
]
}
},
{
"id": "https://doi.org/10.1080/17501911.2026.2730905#onco-edge-paper",
"url": "https://doi.org/10.1080/17501911.2026.2730905",
"title": "Genome-wide DNA methylation landscapes in gallbladder carcinoma: revealing shared and distinct epigenetic signatures across subtypes.",
"content_text": "Published in Epigenomics on 21 September 2026; matched the OnCo record for Papillary carcinoma of the gallbladder.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Epigenomics",
"doi": "10.1080/17501911.2026.2730905",
"records": [
{
"id": "gallbladder-papillary-carcinoma",
"kind": "cancer",
"name": "Papillary carcinoma of the gallbladder",
"url": "https://onco.cc/cancers/gallbladder-papillary-carcinoma/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.plaphy.2026.111774#onco-edge-paper",
"url": "https://doi.org/10.1016/j.plaphy.2026.111774",
"title": "Genome-wide identification of MtTCTPs and functional analysis of MtTCTP3 as a positive regulator of nodulation in Medicago truncatula.",
"content_text": "Published in Plant Physiol Biochem on 21 September 2026; matched the OnCo record for TPT1.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Plant Physiol Biochem",
"doi": "10.1016/j.plaphy.2026.111774",
"records": [
{
"id": "tpt1",
"kind": "target",
"name": "TPT1",
"url": "https://onco.cc/targets/tpt1/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.tranon.2026.103044#onco-edge-paper",
"url": "https://doi.org/10.1016/j.tranon.2026.103044",
"title": "GMPS drives pancreatic cancer progression via suppressing DNA damage, STING activation and cellular senescence.",
"content_text": "Published in Transl Oncol on 21 September 2026; matched the OnCo record for GMPS.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Transl Oncol",
"doi": "10.1016/j.tranon.2026.103044",
"records": [
{
"id": "gmps",
"kind": "target",
"name": "GMPS",
"url": "https://onco.cc/targets/gmps/"
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]
}
},
{
"id": "https://doi.org/10.1038/s41392-026-02958-0#onco-edge-paper",
"url": "https://doi.org/10.1038/s41392-026-02958-0",
"title": "HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma.",
"content_text": "Published in Signal Transduct Target Ther on 21 September 2026; matched the OnCo record for RBX1.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Signal Transduct Target Ther",
"doi": "10.1038/s41392-026-02958-0",
"records": [
{
"id": "rbx1",
"kind": "target",
"name": "RBX1",
"url": "https://onco.cc/targets/rbx1/"
},
{
"id": "rit1",
"kind": "target",
"name": "RIT1",
"url": "https://onco.cc/targets/rit1/"
}
]
}
},
{
"id": "https://doi.org/10.1158/2326-6066.cir-26-0401#onco-edge-paper",
"url": "https://doi.org/10.1158/2326-6066.cir-26-0401",
"title": "IL-21 boosts T cell-therapy efficacy for solid tumors by enhancing mitochondrial Ca2+-mediated motility of effector CD8+ T cells.",
"content_text": "Published in Cancer Immunol Res on 21 September 2026; matched the OnCo record for TCR-T cell therapy.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Cancer Immunol Res",
"doi": "10.1158/2326-6066.cir-26-0401",
"records": [
{
"id": "tcr-t",
"kind": "technology",
"name": "TCR-T cell therapy",
"url": "https://onco.cc/technologies/tcr-t/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.freeradbiomed.2026.09.019#onco-edge-paper",
"url": "https://doi.org/10.1016/j.freeradbiomed.2026.09.019",
"title": "Inducing oxidative stress by targeting the cholesterol biosynthesis pathway augments the efficacy of bortezomib in multiple myeloma.",
"content_text": "Published in Free Radic Biol Med on 21 September 2026; matched the OnCo record for FOXO3.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Free Radic Biol Med",
"doi": "10.1016/j.freeradbiomed.2026.09.019",
"records": [
{
"id": "foxo3",
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"name": "FOXO3",
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}
},
{
"id": "https://doi.org/10.1038/s41392-026-02891-2#onco-edge-paper",
"url": "https://doi.org/10.1038/s41392-026-02891-2",
"title": "Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation.",
"content_text": "Published in Signal Transduct Target Ther on 21 September 2026; matched the OnCo record for Aumolertinib.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Signal Transduct Target Ther",
"doi": "10.1038/s41392-026-02891-2",
"records": [
{
"id": "aumolertinib",
"kind": "drug",
"name": "Aumolertinib",
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}
},
{
"id": "https://doi.org/10.1177/19450265261488655#onco-edge-paper",
"url": "https://doi.org/10.1177/19450265261488655",
"title": "Integrative Genetic and Bioinformatic Analysis of Androgen Pathway Gene Polymorphisms, Testosterone, and PSA Levels in Prostate Cancer.",
"content_text": "Published in Genet Test Mol Biomarkers on 21 September 2026; matched the OnCo record for CYP17A1.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Genet Test Mol Biomarkers",
"doi": "10.1177/19450265261488655",
"records": [
{
"id": "cyp17a1",
"kind": "target",
"name": "CYP17A1",
"url": "https://onco.cc/targets/cyp17a1/"
},
{
"id": "srd5a2",
"kind": "target",
"name": "5-alpha-reductase type 2",
"url": "https://onco.cc/targets/srd5a2/"
}
]
}
},
{
"id": "https://doi.org/10.1002/adma.75063#onco-edge-paper",
"url": "https://doi.org/10.1002/adma.75063",
"title": "Intermolecular Hydrogen Bonds Inducing Paramagnetism for Nondestructive CEST Imaging of Nitric Oxide.",
"content_text": "Published in Adv Mater on 21 September 2026; matched the OnCo record for CCND2.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Adv Mater",
"doi": "10.1002/adma.75063",
"records": [
{
"id": "ccnd2",
"kind": "target",
"name": "CCND2",
"url": "https://onco.cc/targets/ccnd2/"
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]
}
},
{
"id": "https://doi.org/10.1016/j.jtho.2026.106103#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jtho.2026.106103",
"title": "Long-Term Benefit With First-Line Osimertinib Monotherapy in EGFR-Mutated Advanced NSCLC in the Era of Intensified First-Line Therapy.",
"content_text": "Published in J Thorac Oncol on 21 September 2026; matched the OnCo record for LTB.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "J Thorac Oncol",
"doi": "10.1016/j.jtho.2026.106103",
"records": [
{
"id": "ltb",
"kind": "target",
"name": "LTB",
"url": "https://onco.cc/targets/ltb/"
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]
}
},
{
"id": "https://doi.org/10.1158/0008-5472.can-26-0823#onco-edge-paper",
"url": "https://doi.org/10.1158/0008-5472.can-26-0823",
"title": "Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and Single-cell & spatial profiling.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"doi": "10.1158/0008-5472.can-26-0823",
"records": [
{
"id": "rna-seq",
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"name": "RNA sequencing & expression profiling",
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},
{
"id": "single-cell-spatial",
"kind": "technology",
"name": "Single-cell & spatial profiling",
"url": "https://onco.cc/technologies/single-cell-spatial/"
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]
}
},
{
"id": "https://doi.org/10.1016/j.isci.2026.117573#onco-edge-paper",
"url": "https://doi.org/10.1016/j.isci.2026.117573",
"title": "Macrophages promote collagen deposition through circadian regulation of fibroblasts.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics and PDGFRA.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"doi": "10.1016/j.isci.2026.117573",
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{
"id": "proteomics",
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"name": "Proteomics & phosphoproteomics",
"url": "https://onco.cc/technologies/proteomics/"
},
{
"id": "pdgfra",
"kind": "target",
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"url": "https://onco.cc/targets/pdgfra/"
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]
}
},
{
"id": "https://doi.org/10.7554/elife.110703#onco-edge-paper",
"url": "https://doi.org/10.7554/elife.110703",
"title": "MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched KDM3B.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"doi": "10.7554/elife.110703",
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{
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}
},
{
"id": "https://doi.org/10.1038/s41416-026-03628-2#onco-edge-paper",
"url": "https://doi.org/10.1038/s41416-026-03628-2",
"title": "Methodological considerations in defining CBL as a prognostic biomarker in stage II melanoma.",
"content_text": "Published in Br J Cancer on 21 September 2026; matched the OnCo record for CBL.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Br J Cancer",
"doi": "10.1038/s41416-026-03628-2",
"records": [
{
"id": "cbl",
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"name": "CBL",
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}
},
{
"id": "https://doi.org/10.1016/j.tranon.2026.103029#onco-edge-paper",
"url": "https://doi.org/10.1016/j.tranon.2026.103029",
"title": "Multi-omics integration identifies prognostic genes linked to adaptive immunity response and radiosensitivity in cervical cancer.",
"content_text": "Published in Transl Oncol on 21 September 2026; matched the OnCo record for TCL1A.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Transl Oncol",
"doi": "10.1016/j.tranon.2026.103029",
"records": [
{
"id": "tcl1a",
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"name": "TCL1A",
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]
}
},
{
"id": "https://doi.org/10.1007/s11274-026-05286-1#onco-edge-paper",
"url": "https://doi.org/10.1007/s11274-026-05286-1",
"title": "Multifaceted biological activities of linalool: antimicrobial, antibiofilm, cytotoxic, antiproliferative and caspase-3/7 activity.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched PSMA7.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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{
"id": "psma7",
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}
},
{
"id": "https://doi.org/10.3390/nu18183101#onco-edge-paper",
"url": "https://doi.org/10.3390/nu18183101",
"title": "Nutrigenomics and Epigenetic Regulation in Cancer Prevention: Molecular Mechanisms, Dietary Bioactives, and Translational Perspectives.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched DNA methylation profiling, Chemoprevention & risk-reducing surgery and Histone deacetylases.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"doi": "10.3390/nu18183101",
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{
"id": "methylation-profiling",
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"name": "DNA methylation profiling",
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{
"id": "chemoprevention",
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"name": "Chemoprevention & risk-reducing surgery",
"url": "https://onco.cc/technologies/chemoprevention/"
},
{
"id": "hdac",
"kind": "target",
"name": "Histone deacetylases",
"url": "https://onco.cc/targets/hdac/"
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]
}
},
{
"id": "https://doi.org/10.1371/journal.pone.0351911#onco-edge-paper",
"url": "https://doi.org/10.1371/journal.pone.0351911",
"title": "Otoprotective effect of MnTBAP in cisplatin-induced hearing loss.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Sodium thiosulfate.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"kind": "paper",
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"doi": "10.1371/journal.pone.0351911",
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{
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}
},
{
"id": "https://doi.org/10.1136/jitc-2026-015178#onco-edge-paper",
"url": "https://doi.org/10.1136/jitc-2026-015178",
"title": "Phase 1 study of KHK2455, a long-acting, potent and selective IDO1 inhibitor, in combination with avelumab in patients with locally advanced or metastatic urothelial carcinoma.",
"content_text": "Published in J Immunother Cancer on 21 September 2026; matched the OnCo record for CCND2.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"venue": "J Immunother Cancer",
"doi": "10.1136/jitc-2026-015178",
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{
"id": "ccnd2",
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"name": "CCND2",
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},
{
"id": "https://doi.org/10.1186/s41747-026-00810-2#onco-edge-paper",
"url": "https://doi.org/10.1186/s41747-026-00810-2",
"title": "Radiomics and machine learning for differentiating pediatric intramedullary spinal tumors: a pilot study.",
"content_text": "Published in Eur Radiol Exp on 21 September 2026; matched the OnCo record for ITK.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Eur Radiol Exp",
"doi": "10.1186/s41747-026-00810-2",
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{
"id": "itk",
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{
"id": "https://doi.org/10.1002/acr.80167#onco-edge-paper",
"url": "https://doi.org/10.1002/acr.80167",
"title": "Real-world effectiveness and safety of secukinumab in giant cell arteritis: an Italian multicentre cohort study.",
"content_text": "Published in Arthritis Care Res (Hoboken) on 21 September 2026; matched the OnCo record for Tocilizumab.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Arthritis Care Res (Hoboken)",
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"records": [
{
"id": "tocilizumab",
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},
{
"id": "https://doi.org/10.1002/advs.77614#onco-edge-paper",
"url": "https://doi.org/10.1002/advs.77614",
"title": "Ribonucleotides Amplify Mitochondrial DNA-Driven cGAS-STING Activation via FdUMP-ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy.",
"content_text": "Published in Adv Sci (Weinh) on 21 September 2026; matched the OnCo record for Floxuridine.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"venue": "Adv Sci (Weinh)",
"doi": "10.1002/advs.77614",
"records": [
{
"id": "floxuridine",
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"name": "Floxuridine",
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{
"id": "tymp",
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}
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-26-1066#onco-edge-paper",
"url": "https://doi.org/10.1158/1078-0432.ccr-26-1066",
"title": "Safety and Efficacy of Ceralasertib plus Olaparib for Advanced/Metastatic Triple-Negative Breast Cancer in Three Molecular Strata: The Phase II VIOLETTE Study.",
"content_text": "Published in Clin Cancer Res on 21 September 2026; matched the OnCo record for Adavosertib.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Clin Cancer Res",
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"records": [
{
"id": "adavosertib",
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{
"id": "ceralasertib",
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{
"id": "wee1",
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},
{
"id": "https://doi.org/10.1002/ccr3.73599#onco-edge-paper",
"url": "https://doi.org/10.1002/ccr3.73599",
"title": "SMARCB1 (INI1)-Deficient Undifferentiated Rectal Carcinoma Mimicking Sarcoma: A Case Report and Literature Review.",
"content_text": "Published in Clin Case Rep on 21 September 2026; matched the OnCo record for Renal medullary carcinoma.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"venue": "Clin Case Rep",
"doi": "10.1002/ccr3.73599",
"records": [
{
"id": "renal-medullary-carcinoma",
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{
"id": "smarcb1",
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},
{
"id": "https://doi.org/10.1093/bjd/ljag418#onco-edge-paper",
"url": "https://doi.org/10.1093/bjd/ljag418",
"title": "Sustained response (ORR4) as an on-treatment prognostic marker in mogamulizumab-treated mycosis fungoides and Sézary syndrome: the FIL-MOGA study.",
"content_text": "Published in Br J Dermatol on 21 September 2026; matched the OnCo record for Mogamulizumab.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"venue": "Br J Dermatol",
"doi": "10.1093/bjd/ljag418",
"records": [
{
"id": "mogamulizumab",
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},
{
"id": "https://doi.org/10.1038/s41592-026-03219-2#onco-edge-paper",
"url": "https://doi.org/10.1038/s41592-026-03219-2",
"title": "SVPG: a pangenome-based structural variant detection approach and rapid augmentation of pangenome graphs with new samples.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Long-read sequencing and State.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.1038/s41592-026-03219-2",
"records": [
{
"id": "long-read-sequencing",
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{
"id": "state-arc",
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"name": "State",
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}
},
{
"id": "https://doi.org/10.1039/d6tb01432a#onco-edge-paper",
"url": "https://doi.org/10.1039/d6tb01432a",
"title": "Targeting CAF-induced oxidative phosphorylation in Dll4<sup>+</sup> leader cells with injectable BZA-loaded MPDA hydrogel suppresses collective invasion in salivary adenoid cystic carcinoma.",
"content_text": "Published in J Mater Chem B on 21 September 2026; matched the OnCo record for DLL4.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "J Mater Chem B",
"doi": "10.1039/d6tb01432a",
"records": [
{
"id": "dll4",
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"name": "DLL4",
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{
"id": "il6st",
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"url": "https://onco.cc/targets/il6st/"
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},
{
"id": "https://doi.org/10.1002/advs.77708#onco-edge-paper",
"url": "https://doi.org/10.1002/advs.77708",
"title": "Targeting the YAP-BST2 Axis Overcomes Intrinsic Anti-PD-1 Resistance in Metastatic Gastric Cancer.",
"content_text": "Published in Adv Sci (Weinh) on 21 September 2026; matched the OnCo record for ATP4B.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"venue": "Adv Sci (Weinh)",
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{
"id": "atp4b",
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},
{
"id": "https://doi.org/10.1016/j.jval.2026.08.009#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jval.2026.08.009",
"title": "The Implementation of NICE Severity Modifier in the Single Technology Appraisal of Mirvetuximab Soravtansine: External Assessment Group Perspective.",
"content_text": "Published in Value Health on 21 September 2026; matched the OnCo record for KCNH1.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"venue": "Value Health",
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"records": [
{
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},
{
"id": "https://doi.org/10.3390/children13091282#onco-edge-paper",
"url": "https://doi.org/10.3390/children13091282",
"title": "The Situation and Factors Associated with Dental Caries Among Preschool Children in Nakhon Si Thammarat Province, Thailand.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Azacitidine and Decitabine + cedazuridine.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
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{
"id": "azacitidine",
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{
"id": "decitabine-cedazuridine",
"kind": "drug",
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]
}
},
{
"id": "https://doi.org/10.1002/hed.70417#onco-edge-paper",
"url": "https://doi.org/10.1002/hed.70417",
"title": "Toripalimab Plus TPF as Induction Chemoimmunotherapy for the Treatment of Locally Advanced Hypopharyngeal Carcinoma: A Prospective Phase II Study.",
"content_text": "Published in Head Neck on 21 September 2026; matched the OnCo record for Toripalimab.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"venue": "Head Neck",
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"records": [
{
"id": "toripalimab",
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},
{
"id": "https://doi.org/10.1093/sexmed/qfag090#onco-edge-paper",
"url": "https://doi.org/10.1093/sexmed/qfag090",
"title": "Translation, cross-cultural adaptation of longitudinal curriculum objectives in sexual health to Brazilian medical education.",
"content_text": "Published in Sex Med on 21 September 2026; matched the OnCo record for NR4A3.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Sex Med",
"doi": "10.1093/sexmed/qfag090",
"records": [
{
"id": "nr4a3",
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},
{
"id": "https://doi.org/10.1002/art.70348#onco-edge-paper",
"url": "https://doi.org/10.1002/art.70348",
"title": "Treatment approaches to macrophage activation syndrome in real life and priorities for future research: results from the international METAPHOR project.",
"content_text": "Published in Arthritis Rheumatol on 21 September 2026; matched the OnCo record for Emapalumab.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-21",
"precision": "day",
"venue": "Arthritis Rheumatol",
"doi": "10.1002/art.70348",
"records": [
{
"id": "emapalumab",
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"name": "Emapalumab",
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},
{
"id": "https://doi.org/10.3390/cancers18183060#onco-edge-paper",
"url": "https://doi.org/10.3390/cancers18183060",
"title": "Treatment Strategies for Advanced Cutaneous Squamous Cell Carcinoma Following Anti-PD-1 Immunotherapy Failure: A Systematic Review of the Literature and Ongoing Trials.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Oncolytic viruses, EGFR and PD-1.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.3390/cancers18183060",
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{
"id": "oncolytic-virus",
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{
"id": "egfr",
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"name": "EGFR",
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{
"id": "pd1",
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{
"id": "ipilimumab",
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{
"id": "egf",
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},
{
"id": "https://doi.org/10.3390/microorganisms14092110#onco-edge-paper",
"url": "https://doi.org/10.3390/microorganisms14092110",
"title": "Virotherapy for Spinal and Spinal Cord Tumors: Current Evidence and Future Perspectives.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Oncolytic viruses.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.3390/microorganisms14092110",
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"id": "oncolytic-virus",
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}
},
{
"id": "https://doi.org/10.1080/00016489.2026.2686988#onco-edge-paper",
"url": "https://doi.org/10.1080/00016489.2026.2686988",
"title": "What happens next: unexpected malignancies after extracapsular dissection of parotid tumors.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched MET and CCDC6.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
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{
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{
"id": "https://doi.org/10.3390/ijms27188420#onco-edge-paper",
"url": "https://doi.org/10.3390/ijms27188420",
"title": "Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.",
"content_text": "Published on 21 September 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.",
"date_published": "2026-09-21T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-21",
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"doi": "10.3390/ijms27188420",
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},
{
"id": "https://doi.org/10.1038/s43018-026-01237-9#onco-edge-paper",
"url": "https://doi.org/10.1038/s43018-026-01237-9",
"title": "Circulating tumor DNA-guided de-escalation or escalation of adjuvant therapy in high-risk stage II and stage III colon cancer: the phase 2 PEGASUS trial.",
"content_text": "Published in Nat Cancer on 14 September 2026; matched the OnCo record for FOLFIRI.",
"date_published": "2026-09-14T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-14",
"precision": "day",
"venue": "Nat Cancer",
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"records": [
{
"id": "folfiri",
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"name": "FOLFIRI",
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},
{
"id": "https://doi.org/10.1016/j.cell.2026.08.030#onco-edge-paper",
"url": "https://doi.org/10.1016/j.cell.2026.08.030",
"title": "Copper ion-induced MYH9 polymerization executes cuproptosis.",
"content_text": "Published in Cell on 14 September 2026; matched the OnCo record for MYH9.",
"date_published": "2026-09-14T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-14",
"precision": "day",
"venue": "Cell",
"doi": "10.1016/j.cell.2026.08.030",
"records": [
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},
{
"id": "https://doi.org/10.1200/jco-26-00556#onco-edge-paper",
"url": "https://doi.org/10.1200/jco-26-00556",
"title": "P-Loop/αC-Helix Compressing Mutations and Exon 20 Insertions in <i>EGFR</i>-Mutant NSCLC: A Rapidly Evolving Therapeutic Landscape.",
"content_text": "Published in J Clin Oncol on 14 September 2026; matched the OnCo record for Afatinib.",
"date_published": "2026-09-14T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-14",
"precision": "day",
"venue": "J Clin Oncol",
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"records": [
{
"id": "afatinib",
"kind": "drug",
"name": "Afatinib",
"url": "https://onco.cc/drugs/afatinib/"
},
{
"id": "amivantamab",
"kind": "drug",
"name": "Amivantamab",
"url": "https://onco.cc/drugs/amivantamab/"
},
{
"id": "sunvozertinib",
"kind": "drug",
"name": "Sunvozertinib",
"url": "https://onco.cc/drugs/sunvozertinib/"
},
{
"id": "zipalertinib",
"kind": "drug",
"name": "Zipalertinib",
"url": "https://onco.cc/drugs/zipalertinib/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.cell.2026.08.031#onco-edge-paper",
"url": "https://doi.org/10.1016/j.cell.2026.08.031",
"title": "Programmed ribosomal frameshifting triggers translational stress to promote viral replication.",
"content_text": "Published in Cell on 14 September 2026; matched the OnCo record for NDRG1.",
"date_published": "2026-09-14T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-14",
"precision": "day",
"venue": "Cell",
"doi": "10.1016/j.cell.2026.08.031",
"records": [
{
"id": "ndrg1",
"kind": "target",
"name": "NDRG1",
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]
}
},
{
"id": "https://doi.org/10.1186/s42826-026-00298-2#onco-edge-paper",
"url": "https://doi.org/10.1186/s42826-026-00298-2",
"title": "Advancing neurofibromatosis research: a comparative review of animal models and their utility in dissecting the tumor microenvironment.",
"content_text": "Published in Lab Anim Res on 20 September 2026; matched the OnCo record for Genetically engineered mouse models.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Lab Anim Res",
"doi": "10.1186/s42826-026-00298-2",
"records": [
{
"id": "genetically-engineered-mouse-models",
"kind": "technology",
"name": "Genetically engineered mouse models",
"url": "https://onco.cc/technologies/genetically-engineered-mouse-models/"
}
]
}
},
{
"id": "https://doi.org/10.1038/s41388-026-03989-1#onco-edge-paper",
"url": "https://doi.org/10.1038/s41388-026-03989-1",
"title": "Beyond the blood-brain barrier: humanised mice, the missing link in glioblastoma research.",
"content_text": "Published in Oncogene on 20 September 2026; matched the OnCo record for Humanised mouse models.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Oncogene",
"doi": "10.1038/s41388-026-03989-1",
"records": [
{
"id": "humanised-mouse-models",
"kind": "technology",
"name": "Humanised mouse models",
"url": "https://onco.cc/technologies/humanised-mouse-models/"
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]
}
},
{
"id": "https://doi.org/10.3390/cells15181712#onco-edge-paper",
"url": "https://doi.org/10.3390/cells15181712",
"title": "Bone Aging and Glycative Stress: Convergent and Divergent Mechanisms Driving Skeletal Deterioration.",
"content_text": "Published on 20 September 2026 after first appearing as a preprint; matched Senolytics after cancer treatment and RANK ligand.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"doi": "10.3390/cells15181712",
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{
"id": "rejuv-frontier-senolytics",
"kind": "technology",
"name": "Senolytics after cancer treatment",
"url": "https://onco.cc/technologies/rejuv-frontier-senolytics/"
},
{
"id": "rankl",
"kind": "target",
"name": "RANK ligand",
"url": "https://onco.cc/targets/rankl/"
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]
}
},
{
"id": "https://doi.org/10.1007/s10552-026-02252-y#onco-edge-paper",
"url": "https://doi.org/10.1007/s10552-026-02252-y",
"title": "Bridging the data latency gap: automated extraction of genomic biomarkers from unstructured clinical documents to support real-world oncology data.",
"content_text": "Published in Cancer Causes Control on 20 September 2026; matched the OnCo record for Oncotype DX.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Cancer Causes Control",
"doi": "10.1007/s10552-026-02252-y",
"records": [
{
"id": "oncotype-dx",
"kind": "drug",
"name": "Oncotype DX",
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}
},
{
"id": "https://doi.org/10.1016/j.critrevonc.2026.105608#onco-edge-paper",
"url": "https://doi.org/10.1016/j.critrevonc.2026.105608",
"title": "Current Management and Investigational Therapeutic Strategies in Penile Squamous Cell Carcinoma: A Narrative Review.",
"content_text": "Published in Crit Rev Oncol Hematol on 20 September 2026; matched the OnCo record for Penile cancer.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Crit Rev Oncol Hematol",
"doi": "10.1016/j.critrevonc.2026.105608",
"records": [
{
"id": "penile",
"kind": "cancer",
"name": "Penile cancer",
"url": "https://onco.cc/cancers/penile/"
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]
}
},
{
"id": "https://doi.org/10.1002/jso.70405#onco-edge-paper",
"url": "https://doi.org/10.1002/jso.70405",
"title": "Dynamic ctDNA Monitoring Predicts Recurrence and Guides Therapy in Postoperative Hepatocellular Carcinoma.",
"content_text": "Published in J Surg Oncol on 20 September 2026; matched the OnCo record for ASXL1.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "J Surg Oncol",
"doi": "10.1002/jso.70405",
"records": [
{
"id": "asxl1",
"kind": "target",
"name": "ASXL1",
"url": "https://onco.cc/targets/asxl1/"
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{
"id": "https://doi.org/10.1016/j.critrevonc.2026.105607#onco-edge-paper",
"url": "https://doi.org/10.1016/j.critrevonc.2026.105607",
"title": "Emerging Patterns of Kidney Cancer in Young Adults: Where Do We Stand? Emerging Patterns of Kidney Cancer in Young Adults: Where Do We Stand?",
"content_text": "Published in Crit Rev Oncol Hematol on 20 September 2026; matched the OnCo record for Belzutifan.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Crit Rev Oncol Hematol",
"doi": "10.1016/j.critrevonc.2026.105607",
"records": [
{
"id": "belzutifan",
"kind": "drug",
"name": "Belzutifan",
"url": "https://onco.cc/drugs/belzutifan/"
},
{
"id": "renal-medullary-carcinoma",
"kind": "cancer",
"name": "Renal medullary carcinoma",
"url": "https://onco.cc/cancers/renal-medullary-carcinoma/"
}
]
}
},
{
"id": "https://doi.org/10.3390/ijms27188374#onco-edge-paper",
"url": "https://doi.org/10.3390/ijms27188374",
"title": "From Damage to Dysregulation: Reframing Oxidative Stress and Redox Homeostasis in Central Nervous System Disease.",
"content_text": "Published on 20 September 2026 after first appearing as a preprint; matched State and SET.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"doi": "10.3390/ijms27188374",
"records": [
{
"id": "state-arc",
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"name": "State",
"url": "https://onco.cc/technologies/state-arc/"
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{
"id": "set",
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"name": "SET",
"url": "https://onco.cc/targets/set/"
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]
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},
{
"id": "https://doi.org/10.1007/s12012-026-10191-y#onco-edge-paper",
"url": "https://doi.org/10.1007/s12012-026-10191-y",
"title": "Genetic and Molecular Determinants of Cancer Therapy-Related Cardiovascular Toxicity.",
"content_text": "Published in Cardiovasc Toxicol on 20 September 2026; matched the OnCo record for HER4.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Cardiovasc Toxicol",
"doi": "10.1007/s12012-026-10191-y",
"records": [
{
"id": "erbb4",
"kind": "target",
"name": "HER4",
"url": "https://onco.cc/targets/erbb4/"
},
{
"id": "nrg1",
"kind": "target",
"name": "NRG1",
"url": "https://onco.cc/targets/nrg1/"
},
{
"id": "strain-echocardiography-gls",
"kind": "technology",
"name": "Strain echocardiography",
"url": "https://onco.cc/technologies/strain-echocardiography-gls/"
},
{
"id": "top2b",
"kind": "target",
"name": "TOP2B",
"url": "https://onco.cc/targets/top2b/"
}
]
}
},
{
"id": "https://doi.org/10.1111/bjh.70850#onco-edge-paper",
"url": "https://doi.org/10.1111/bjh.70850",
"title": "Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia-Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups.",
"content_text": "Published in Br J Haematol on 20 September 2026; matched the OnCo record for Acute lymphoblastic leukaemia.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Br J Haematol",
"doi": "10.1111/bjh.70850",
"records": [
{
"id": "all-leukemia",
"kind": "cancer",
"name": "Acute lymphoblastic leukaemia",
"url": "https://onco.cc/cancers/all-leukemia/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.actbio.2026.09.035#onco-edge-paper",
"url": "https://doi.org/10.1016/j.actbio.2026.09.035",
"title": "Leukemic Stem Cell-Targeted Liposomal Nanoimmunotherapy Reverses Immune Evasion and Inhibits Fusion Oncoprotein-Driven Acute Myeloid Leukemia by Silencing B-Cell Lymphoma 2.",
"content_text": "Published in Acta Biomater on 20 September 2026; matched the OnCo record for CD123.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Acta Biomater",
"doi": "10.1016/j.actbio.2026.09.035",
"records": [
{
"id": "cd123",
"kind": "target",
"name": "CD123",
"url": "https://onco.cc/targets/cd123/"
},
{
"id": "mllt3",
"kind": "target",
"name": "MLLT3",
"url": "https://onco.cc/targets/mllt3/"
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]
}
},
{
"id": "https://doi.org/10.1002/ijc.70745#onco-edge-paper",
"url": "https://doi.org/10.1002/ijc.70745",
"title": "Longitudinal Associations of Oxaliplatin Treatment With Chemotherapy-Induced Peripheral Neuropathy in Colorectal cancer Survivors up to 2 Years Post-Treatment.",
"content_text": "Published in Int J Cancer on 20 September 2026; matched the OnCo record for CAPOX.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Int J Cancer",
"doi": "10.1002/ijc.70745",
"records": [
{
"id": "capox",
"kind": "drug",
"name": "CAPOX",
"url": "https://onco.cc/drugs/capox/"
}
]
}
},
{
"id": "https://doi.org/10.1002/jcla.70351#onco-edge-paper",
"url": "https://doi.org/10.1002/jcla.70351",
"title": "Low-Concentration Enhancement Effect: Enabling Sensitive Detection of EML4-ALK Variants via Multiplex RT-MIRA.",
"content_text": "Published in J Clin Lab Anal on 20 September 2026; matched the OnCo record for EML4.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "J Clin Lab Anal",
"doi": "10.1002/jcla.70351",
"records": [
{
"id": "eml4",
"kind": "target",
"name": "EML4",
"url": "https://onco.cc/targets/eml4/"
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]
}
},
{
"id": "https://doi.org/10.1007/s10552-026-02242-0#onco-edge-paper",
"url": "https://doi.org/10.1007/s10552-026-02242-0",
"title": "Predictors of perceived value of multi-cancer early detection testing: a national PRECEDE-PROCEED framework study.",
"content_text": "Published in Cancer Causes Control on 20 September 2026; matched the OnCo record for Multi-cancer early detection.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Cancer Causes Control",
"doi": "10.1007/s10552-026-02242-0",
"records": [
{
"id": "mced",
"kind": "technology",
"name": "Multi-cancer early detection",
"url": "https://onco.cc/technologies/mced/"
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]
}
},
{
"id": "https://doi.org/10.3390/nu18183086#onco-edge-paper",
"url": "https://doi.org/10.3390/nu18183086",
"title": "Probe-Based Confocal Laser Endomicroscopy During Immune Checkpoint Inhibitor Therapy: A Translational Framework Linking Intestinal Barrier Function, Microbiota, and Clinical Outcomes.",
"content_text": "Published on 20 September 2026 after first appearing as a preprint; matched Immune checkpoint inhibitors.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"doi": "10.3390/nu18183086",
"records": [
{
"id": "checkpoint-inhibitor",
"kind": "technology",
"name": "Immune checkpoint inhibitors",
"url": "https://onco.cc/technologies/checkpoint-inhibitor/"
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]
}
},
{
"id": "https://doi.org/10.1080/13543776.2026.2735861#onco-edge-paper",
"url": "https://doi.org/10.1080/13543776.2026.2735861",
"title": "Progress with FAK inhibitors in the patent literature (2020-present).",
"content_text": "Published in Expert Opin Ther Pat on 20 September 2026; matched the OnCo record for Avutometinib + defactinib.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Expert Opin Ther Pat",
"doi": "10.1080/13543776.2026.2735861",
"records": [
{
"id": "avutometinib-defactinib",
"kind": "drug",
"name": "Avutometinib + defactinib",
"url": "https://onco.cc/drugs/avutometinib-defactinib/"
}
]
}
},
{
"id": "https://doi.org/10.1016/j.biortech.2026.135869#onco-edge-paper",
"url": "https://doi.org/10.1016/j.biortech.2026.135869",
"title": "Simultaneous multi-pollutant removal from photovoltaic wastewater by aluminum-modified biochar-enhanced partial nitritation-anammox process.",
"content_text": "Published in Bioresour Technol on 20 September 2026; matched the OnCo record for Secretory carcinoma of the breast.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Bioresour Technol",
"doi": "10.1016/j.biortech.2026.135869",
"records": [
{
"id": "secretory-carcinoma-breast",
"kind": "cancer",
"name": "Secretory carcinoma of the breast",
"url": "https://onco.cc/cancers/secretory-carcinoma-breast/"
}
]
}
},
{
"id": "https://doi.org/10.3390/cells15181713#onco-edge-paper",
"url": "https://doi.org/10.3390/cells15181713",
"title": "The p53-Associated Regulation of ATF4 mRNA Expression Involves p21 and p130 in a Stress-Dependent Manner.",
"content_text": "Published on 20 September 2026 after first appearing as a preprint; matched CDKN1A.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
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"doi": "10.3390/cells15181713",
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},
{
"id": "https://doi.org/10.1080/14796694.2026.2732570#onco-edge-paper",
"url": "https://doi.org/10.1080/14796694.2026.2732570",
"title": "Translating avelumab maintenance into clinical practice: nationwide outcomes in Czech patients with advanced or metastatic urothelial carcinoma.",
"content_text": "Published in Future Oncol on 20 September 2026; matched the OnCo record for Avelumab.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Future Oncol",
"doi": "10.1080/14796694.2026.2732570",
"records": [
{
"id": "avelumab",
"kind": "drug",
"name": "Avelumab",
"url": "https://onco.cc/drugs/avelumab/"
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]
}
},
{
"id": "https://doi.org/10.1016/j.clinme.2026.100643#onco-edge-paper",
"url": "https://doi.org/10.1016/j.clinme.2026.100643",
"title": "Updates to contemporary care of glioblastoma.",
"content_text": "Published in Clin Med (Lond) on 20 September 2026; matched the OnCo record for Tumour treating fields.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Clin Med (Lond)",
"doi": "10.1016/j.clinme.2026.100643",
"records": [
{
"id": "ttfields",
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"name": "Tumour treating fields",
"url": "https://onco.cc/technologies/ttfields/"
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}
},
{
"id": "https://doi.org/10.1007/s13577-026-01454-5#onco-edge-paper",
"url": "https://doi.org/10.1007/s13577-026-01454-5",
"title": "Upstream regulatory mechanisms and clinical significance of IQGAP2 deficiency in affecting PI3K activity to drive cell proliferation.",
"content_text": "Published in Hum Cell on 20 September 2026; matched the OnCo record for AREG.",
"date_published": "2026-09-20T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-20",
"precision": "day",
"venue": "Hum Cell",
"doi": "10.1007/s13577-026-01454-5",
"records": [
{
"id": "areg",
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"name": "AREG",
"url": "https://onco.cc/targets/areg/"
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{
"id": "ereg",
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"url": "https://onco.cc/targets/ereg/"
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{
"id": "iqgap1",
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"url": "https://onco.cc/targets/iqgap1/"
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}
},
{
"id": "https://doi.org/10.1096/fba.2026-00185#onco-edge-paper",
"url": "https://doi.org/10.1096/fba.2026-00185",
"title": "<i>XIST</i> Is a Key Modulator Associated With the Adhesome Network.",
"content_text": "Published on 19 September 2026 after first appearing as a preprint; matched Atlas.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"doi": "10.1096/fba.2026-00185",
"records": [
{
"id": "atlas-aignostics",
"kind": "technology",
"name": "Atlas",
"url": "https://onco.cc/technologies/atlas-aignostics/"
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]
}
},
{
"id": "https://doi.org/10.1016/j.bioorg.2026.110552#onco-edge-paper",
"url": "https://doi.org/10.1016/j.bioorg.2026.110552",
"title": "A pyridone-fused imidazo[1,2-a]pyridine hybrid binds to tubulin at the vinblastine site, depolymerizes microtubules and inhibits Cancer cell proliferation.",
"content_text": "Published in Bioorg Chem on 19 September 2026; matched the OnCo record for Vinblastine.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Bioorg Chem",
"doi": "10.1016/j.bioorg.2026.110552",
"records": [
{
"id": "vinblastine",
"kind": "drug",
"name": "Vinblastine",
"url": "https://onco.cc/drugs/vinblastine/"
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}
},
{
"id": "https://doi.org/10.1007/s10689-026-00603-x#onco-edge-paper",
"url": "https://doi.org/10.1007/s10689-026-00603-x",
"title": "A systematic review of cancer risks associated with MITF variants.",
"content_text": "Published on 19 September 2026 after first appearing as a preprint; matched MITF.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"doi": "10.1007/s10689-026-00603-x",
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{
"id": "mitf",
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{
"id": "https://doi.org/10.1007/s12308-026-00734-1#onco-edge-paper",
"url": "https://doi.org/10.1007/s12308-026-00734-1",
"title": "Acute myeloid leukemia arising in treated chronic lymphocytic leukemia/small lymphocytic lymphoma: a challenge in analysis of lineage relationship.",
"content_text": "Published in J Hematop on 19 September 2026; matched the OnCo record for CD123.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
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"_onco": {
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"venue": "J Hematop",
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"url": "https://doi.org/10.1002/mc.70177",
"title": "ARID2 Loss Destabilizes PBAF and Drives Colorectal Cancer.",
"content_text": "Published in Mol Carcinog on 19 September 2026; matched the OnCo record for ARID1A.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Mol Carcinog",
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{
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{
"id": "https://doi.org/10.1016/j.ctarc.2026.101444#onco-edge-paper",
"url": "https://doi.org/10.1016/j.ctarc.2026.101444",
"title": "Beyond Exons 19 and 21: mapping the clinical and molecular diversity of uncommon EGFR mutations in a Brazilian NSCLC cohort.",
"content_text": "Published in Cancer Treat Res Commun on 19 September 2026; matched the OnCo record for STK11.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
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"date": "2026-09-19",
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"venue": "Cancer Treat Res Commun",
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{
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"title": "Beyond poly(ADP-ribose) polymerase inhibition: emerging therapeutic strategies for germline BRCA1/2-mutated and PALB2-mutated breast cancers.",
"content_text": "Published in Curr Opin Oncol on 19 September 2026; matched the OnCo record for POLQ.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Curr Opin Oncol",
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{
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{
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{
"id": "https://doi.org/10.1038/s41393-026-01275-1#onco-edge-paper",
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"title": "Blood flow restricted exercise with and without transcutaneous spinal cord stimulation via telehealth in persons with tetraplegia. A protocol for randomized clinical trial.",
"content_text": "Published in Spinal Cord on 19 September 2026; matched the OnCo record for Basal-like 1 triple-negative breast cancer.",
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"_onco": {
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"venue": "Spinal Cord",
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{
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{
"id": "https://doi.org/10.1002/jha2.70385#onco-edge-paper",
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"title": "Clinicopathologic Characteristics of Somatic <i>TP53</i> Mutations in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Systematic Review.",
"content_text": "Published in EJHaem on 19 September 2026; matched the OnCo record for BCR::ABL1.",
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"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"venue": "EJHaem",
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{
"id": "https://doi.org/10.1016/j.critrevonc.2026.105610#onco-edge-paper",
"url": "https://doi.org/10.1016/j.critrevonc.2026.105610",
"title": "CRISPR and Gene Editing Approaches in Prostate Cancer: Clinical Applications and Therapeutic Potential.",
"content_text": "Published in Crit Rev Oncol Hematol on 19 September 2026; matched the OnCo record for TMPRSS2.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Crit Rev Oncol Hematol",
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{
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{
"id": "https://doi.org/10.1016/j.ymthe.2026.09.020#onco-edge-paper",
"url": "https://doi.org/10.1016/j.ymthe.2026.09.020",
"title": "Development of CRISPR_SCD001, an Autologous Hematopoietic Stem Cell Gene Therapy for Sickle Cell Disease after CRISPR-Cas9 Mediated Correction.",
"content_text": "Published in Mol Ther on 19 September 2026; matched the OnCo record for HBB.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Mol Ther",
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{
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{
"id": "plerixafor",
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{
"id": "https://doi.org/10.1136/bmjpo-2026-004903#onco-edge-paper",
"url": "https://doi.org/10.1136/bmjpo-2026-004903",
"title": "Distribution, socioeconomic inequalities and contributing factors of anaemia prevalence across wealth index among Indian adolescent girls: multivariate decomposition analysis of nationally representative survey.",
"content_text": "Published in BMJ Paediatr Open on 19 September 2026; matched the OnCo record for HB-200.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "BMJ Paediatr Open",
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{
"id": "hb-200",
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{
"id": "https://doi.org/10.1016/j.radonc.2026.111784#onco-edge-paper",
"url": "https://doi.org/10.1016/j.radonc.2026.111784",
"title": "Efficacy and safety of omitting the clinical target volume in limited-stage small cell lung cancer: a large-scale multicenter real-world study.",
"content_text": "Published in Radiother Oncol on 19 September 2026; matched the OnCo record for Limited-stage small-cell lung cancer.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Radiother Oncol",
"doi": "10.1016/j.radonc.2026.111784",
"records": [
{
"id": "limited-stage-sclc",
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{
"id": "https://doi.org/10.1016/j.compbiolchem.2026.109395#onco-edge-paper",
"url": "https://doi.org/10.1016/j.compbiolchem.2026.109395",
"title": "Elucidating the molecular nexus between dental developmental anomalies and chronic inflammatory diseases: A computational systems biology analysis of genomic sequence homology using matrix factorization.",
"content_text": "Published in Comput Biol Chem on 19 September 2026; matched the OnCo record for MERTK.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Comput Biol Chem",
"doi": "10.1016/j.compbiolchem.2026.109395",
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{
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{
"id": "https://doi.org/10.3390/bioengineering13091086#onco-edge-paper",
"url": "https://doi.org/10.3390/bioengineering13091086",
"title": "Extracellular Vesicles and Their Role in Osteogenesis.",
"content_text": "Published on 19 September 2026 after first appearing as a preprint; matched Mesenchymal stromal cells for tissue damage.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"doi": "10.3390/bioengineering13091086",
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{
"id": "https://doi.org/10.1007/s12282-026-01916-6#onco-edge-paper",
"url": "https://doi.org/10.1007/s12282-026-01916-6",
"title": "Five-year outcomes of partial breast proton beam therapy without lumpectomy for early-stage breast cancer: an interventional prospective study.",
"content_text": "Published on 19 September 2026 after first appearing as a preprint; matched MRI, Proton therapy and Estrogen receptor.",
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"tags": [
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"_onco": {
"kind": "paper",
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{
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{
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{
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{
"id": "https://doi.org/10.1007/s12032-026-03388-2#onco-edge-paper",
"url": "https://doi.org/10.1007/s12032-026-03388-2",
"title": "Gastrodin enhances the spleen immune function in erythroleukemia by regulating T-cell receptor signaling pathway.",
"content_text": "Published in Med Oncol on 19 September 2026; matched the OnCo record for ITK.",
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"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Med Oncol",
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{
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{
"id": "https://doi.org/10.1007/s00259-026-08191-9#onco-edge-paper",
"url": "https://doi.org/10.1007/s00259-026-08191-9",
"title": "Head-to-head comparison of [¹⁸F]F-PSMA-1007 PET/CT and [⁶⁸Ga]Ga-PSMA-11 PET/CT for intraprostatic tumour detection and localisation using histopathology as reference: A prospective single-centre diagnostic accuracy study.",
"content_text": "Published in Eur J Nucl Med Mol Imaging on 19 September 2026; matched the OnCo record for Gallium-68 gozetotide.",
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"tags": [
"paper"
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"_onco": {
"kind": "paper",
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"venue": "Eur J Nucl Med Mol Imaging",
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{
"id": "https://doi.org/10.1177/10668969261480728#onco-edge-paper",
"url": "https://doi.org/10.1177/10668969261480728",
"title": "Hepatocellular Carcinoma With a Grade 3 Neuroendocrine Tumor Component: A Case Report.",
"content_text": "Published in Int J Surg Pathol on 19 September 2026; matched the OnCo record for Grade 3 well-differentiated neuroendocrine tumour.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
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"venue": "Int J Surg Pathol",
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{
"id": "https://doi.org/10.1038/s41420-026-03344-z#onco-edge-paper",
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"title": "Immunogenic cell death as a mechanism of synergy between sunitinib and <sup>177</sup>Lu-DOTATATE peptide receptor radionuclide therapy in pancreatic neuroendocrine tumors.",
"content_text": "Published in Cell Death Discov on 19 September 2026; matched the OnCo record for Lutetium-177 dotatate.",
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"tags": [
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"_onco": {
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"venue": "Cell Death Discov",
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{
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{
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{
"id": "https://doi.org/10.1016/j.bcp.2026.118491#onco-edge-paper",
"url": "https://doi.org/10.1016/j.bcp.2026.118491",
"title": "In vivo CAR‑T cell therapy: mechanisms, clinical advances and optimization strategies.",
"content_text": "Published in Biochem Pharmacol on 19 September 2026; matched the OnCo record for In vivo CAR-T.",
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"tags": [
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"_onco": {
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"date": "2026-09-19",
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"venue": "Biochem Pharmacol",
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{
"id": "https://doi.org/10.1080/19932820.2026.2735579#onco-edge-paper",
"url": "https://doi.org/10.1080/19932820.2026.2735579",
"title": "Integrating immunophenotyping and morphology in the diagnosis of acute leukemia at the National Oncology Center, Sana'a, Yemen.",
"content_text": "Published in Libyan J Med on 19 September 2026; matched the OnCo record for Anal high-grade squamous intraepithelial lesions.",
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"_onco": {
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"venue": "Libyan J Med",
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{
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{
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{
"id": "https://doi.org/10.1016/j.oraloncology.2026.108124#onco-edge-paper",
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"title": "Investigating the impact of margins on the management of oropharyngeal cancer treated with transoral robotic surgery: a survey of head and neck oncologists' treatment patterns.",
"content_text": "Published in Oral Oncol on 19 September 2026; matched the OnCo record for Transoral robotic surgery.",
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"_onco": {
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"venue": "Oral Oncol",
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{
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"url": "https://doi.org/10.1016/j.bcp.2026.118490",
"title": "IRF1-driven chromatin and transcriptional regulation determines the anti-tumor responses to all-trans retinoic acid across cancer types.",
"content_text": "Published in Biochem Pharmacol on 19 September 2026; matched the OnCo record for Acute promyelocytic leukaemia.",
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"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Biochem Pharmacol",
"doi": "10.1016/j.bcp.2026.118490",
"records": [
{
"id": "apl",
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{
"id": "https://doi.org/10.1016/j.cellsig.2026.112895#onco-edge-paper",
"url": "https://doi.org/10.1016/j.cellsig.2026.112895",
"title": "Lenalidomide triggers ferroptosis in multiple myeloma by blocking the c-Maf/USP7 signaling pathway to induce the ubiquitination and degradation of FTH1.",
"content_text": "Published in Cell Signal on 19 September 2026; matched the OnCo record for MAF.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Cell Signal",
"doi": "10.1016/j.cellsig.2026.112895",
"records": [
{
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{
"id": "https://doi.org/10.1007/s00109-026-02718-1#onco-edge-paper",
"url": "https://doi.org/10.1007/s00109-026-02718-1",
"title": "MicroRNA-122 as a regulator and biomarker of liver disease.",
"content_text": "Published in J Mol Med (Berl) on 19 September 2026; matched the OnCo record for FOXO3.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "J Mol Med (Berl)",
"doi": "10.1007/s00109-026-02718-1",
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},
{
"id": "https://doi.org/10.3390/cells15181705#onco-edge-paper",
"url": "https://doi.org/10.3390/cells15181705",
"title": "Neuregulin-1 as a Context-Dependent Regulator of Neuroinflammation and Neural Repair: Mechanisms, Disease Relevance, and Therapeutic Challenges.",
"content_text": "Published on 19 September 2026 after first appearing as a preprint; matched HER2, HER4 and NRG1.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"doi": "10.3390/cells15181705",
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"id": "her2",
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{
"id": "erbb4",
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"name": "HER4",
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{
"id": "nrg1",
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{
"id": "egf",
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{
"id": "https://doi.org/10.1038/s41416-026-03608-6#onco-edge-paper",
"url": "https://doi.org/10.1038/s41416-026-03608-6",
"title": "PAX9 activates autophagy through a transcription-dependent mechanism, promoting EGFR degradation to restrict cell survival in oral cancer.",
"content_text": "Published in Br J Cancer on 19 September 2026; matched the OnCo record for PAX9.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
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"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Br J Cancer",
"doi": "10.1038/s41416-026-03608-6",
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{
"id": "pax9",
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{
"id": "https://doi.org/10.1007/s10555-026-10381-8#onco-edge-paper",
"url": "https://doi.org/10.1007/s10555-026-10381-8",
"title": "Precision therapeutic strategies for advanced gastrointestinal stromal tumors.",
"content_text": "Published in Cancer Metastasis Rev on 19 September 2026; matched the OnCo record for Ripretinib.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Cancer Metastasis Rev",
"doi": "10.1007/s10555-026-10381-8",
"records": [
{
"id": "ripretinib",
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{
"id": "https://doi.org/10.1016/j.jtct.2026.09.008#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jtct.2026.09.008",
"title": "Prognostic Associations of Molecular MRD and Genomic Features in ZNF384-Rearranged B-ALL Undergoing Allo-HSCT.",
"content_text": "Published in Transplant Cell Ther on 19 September 2026; matched the OnCo record for CD33.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
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"venue": "Transplant Cell Ther",
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{
"id": "cd33",
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"name": "CD33",
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{
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{
"id": "ikzf1",
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{
"id": "tcf3",
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{
"id": "https://doi.org/10.1007/s40261-026-01592-6#onco-edge-paper",
"url": "https://doi.org/10.1007/s40261-026-01592-6",
"title": "Real-World Treatment Patterns, Healthcare Resource Use, and Costs in Patients with Follicular Lymphoma, Waldenström Macroglobulinemia, and Marginal Zone Lymphoma: A Claims-Based Study in the USA.",
"content_text": "Published in Clin Drug Investig on 19 September 2026; matched the OnCo record for Bendamustine.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Clin Drug Investig",
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"records": [
{
"id": "bendamustine",
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{
"id": "https://doi.org/10.1186/s12985-026-03132-2#onco-edge-paper",
"url": "https://doi.org/10.1186/s12985-026-03132-2",
"title": "Regulatory roles of G-quadruplexes and G-quadruplex-binding proteins across the enhancer and promoter of the HBV genome.",
"content_text": "Published in Virol J on 19 September 2026; matched the OnCo record for CNBP.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Virol J",
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{
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{
"id": "https://doi.org/10.1016/j.abb.2026.111003#onco-edge-paper",
"url": "https://doi.org/10.1016/j.abb.2026.111003",
"title": "ROS-Activated SHP-1 Signaling Underlies Artesunate-Mediated Inhibition of EMT and STAT3-Driven Prostate Cancer Progression.",
"content_text": "Published in Arch Biochem Biophys on 19 September 2026; matched the OnCo record for PTPN6.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Arch Biochem Biophys",
"doi": "10.1016/j.abb.2026.111003",
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{
"id": "ptpn6",
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"name": "PTPN6",
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{
"id": "https://doi.org/10.1177/10668969261479347#onco-edge-paper",
"url": "https://doi.org/10.1177/10668969261479347",
"title": "Salivary Duct Carcinoma With Rhabdoid and Signet-Ring Cell Features Mimicking Invasive Lobular Carcinoma of the Breast: A Case Report and Review of the Literature.",
"content_text": "Published in Int J Surg Pathol on 19 September 2026; matched the OnCo record for Invasive lobular carcinoma of the breast.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Int J Surg Pathol",
"doi": "10.1177/10668969261479347",
"records": [
{
"id": "invasive-lobular-carcinoma",
"kind": "cancer",
"name": "Invasive lobular carcinoma of the breast",
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{
"id": "salivary-duct-carcinoma",
"kind": "cancer",
"name": "Salivary duct carcinoma",
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]
}
},
{
"id": "https://doi.org/10.1177/10668969261472121#onco-edge-paper",
"url": "https://doi.org/10.1177/10668969261472121",
"title": "SOX17 and TRPS1 in Müllerian, Breast, and Mesothelial Tumors: Tissue-Based Specificity Profiles and Diagnostic Pitfalls in Malignant Serous Effusions.",
"content_text": "Published in Int J Surg Pathol on 19 September 2026; matched the OnCo record for SOX17.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Int J Surg Pathol",
"doi": "10.1177/10668969261472121",
"records": [
{
"id": "sox17",
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"name": "SOX17",
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{
"id": "trps1",
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}
},
{
"id": "https://doi.org/10.1016/j.jconrel.2026.115346#onco-edge-paper",
"url": "https://doi.org/10.1016/j.jconrel.2026.115346",
"title": "Stepwise neutrophil-to-neuron targeting nanotherapy for mitochondrial protection and blood-brain barrier preservation in ischemic stroke.",
"content_text": "Published in J Control Release on 19 September 2026; matched the OnCo record for TET1.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "J Control Release",
"doi": "10.1016/j.jconrel.2026.115346",
"records": [
{
"id": "tet1",
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"name": "TET1",
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{
"id": "https://doi.org/10.1007/s12185-026-04282-3#onco-edge-paper",
"url": "https://doi.org/10.1007/s12185-026-04282-3",
"title": "Strategies to prevent post-transplant relapse in acute myeloid leukemia and myelodysplastic syndromes.",
"content_text": "Published in Int J Hematol on 19 September 2026; matched the OnCo record for Decitabine.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Int J Hematol",
"doi": "10.1007/s12185-026-04282-3",
"records": [
{
"id": "decitabine",
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{
"id": "quizartinib",
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"name": "Quizartinib",
"url": "https://onco.cc/drugs/quizartinib/"
}
]
}
},
{
"id": "https://doi.org/10.1007/s11523-026-01245-w#onco-edge-paper",
"url": "https://doi.org/10.1007/s11523-026-01245-w",
"title": "Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer.",
"content_text": "Published in Target Oncol on 19 September 2026; matched the OnCo record for Tucatinib.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Target Oncol",
"doi": "10.1007/s11523-026-01245-w",
"records": [
{
"id": "tucatinib",
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"name": "Tucatinib",
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}
},
{
"id": "https://doi.org/10.1007/s11701-026-03986-2#onco-edge-paper",
"url": "https://doi.org/10.1007/s11701-026-03986-2",
"title": "TAPESTRY study: impact of prior transurethral resection of the prostate on outcomes after robot-assisted radical prostatectomy: a propensity score-matched cohort study.",
"content_text": "Published on 19 September 2026 after first appearing as a preprint; matched KLK3.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
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"date": "2026-09-19",
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"doi": "10.1007/s11701-026-03986-2",
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{
"id": "https://doi.org/10.1007/s10147-026-03192-y#onco-edge-paper",
"url": "https://doi.org/10.1007/s10147-026-03192-y",
"title": "Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study.",
"content_text": "Published in Int J Clin Oncol on 19 September 2026; matched the OnCo record for Amrubicin.",
"date_published": "2026-09-19T00:00:00Z",
"tags": [
"paper"
],
"_onco": {
"kind": "paper",
"date": "2026-09-19",
"precision": "day",
"venue": "Int J Clin Oncol",
"doi": "10.1007/s10147-026-03192-y",
"records": [
{
"id": "amrubicin",
"kind": "drug",
"name": "Amrubicin",
"url": "https://onco.cc/drugs/amrubicin/"
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}
},
{
"id": "https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-new-breast-cancer-treatment#onco-edge-approval",
"url": "https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-new-breast-cancer-treatment",
"title": "Accelerated approval: Camizestrant (US)",
"content_text": "Accelerated approval (Etcamah) The confirmatory requirement was still open 0.0 years later, when the FDA's table was read.",
"date_published": "2026-09-04T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-09-04",
"precision": "day",
"venue": "FDA",
"records": [
{
"id": "camizestrant",
"kind": "drug",
"name": "Camizestrant",
"url": "https://onco.cc/drugs/camizestrant/"
},
{
"id": "breast-hr-positive",
"kind": "cancer",
"name": "HR-positive / HER2-negative breast cancer",
"url": "https://onco.cc/cancers/breast-hr-positive/"
},
{
"id": "hr-positive-metastatic-post-cdk46",
"kind": "cancer",
"name": "HR-positive metastatic breast cancer after CDK4/6 inhibitors",
"url": "https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/"
},
{
"id": "estrogen-receptor",
"kind": "target",
"name": "Estrogen receptor",
"url": "https://onco.cc/targets/estrogen-receptor/"
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]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-camizestrant-cdk46-inhibitor-esr1-mutated-hr-positive-her2-negative#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-camizestrant-cdk46-inhibitor-esr1-mutated-hr-positive-her2-negative",
"title": "FDA grants accelerated approval to camizestrant with a CDK4/6 inhibitor for ESR1-Mutated HR-positive, HER2-negative locally advanced or metastatic breast cancer",
"content_text": "On September 4, 2026, the Food and Drug Administration granted accelerated approval to camizestrant (Etcamah, AstraZeneca), an estrogen receptor antagonist, in combination with a CDK4/6 inhibitor (abemaciclib, palbociclib, or ribociclib) for adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer upon detection of estrogen receptor-1 (ESR1) mutation during aromatase inhibitor and CDK4/6 inhibitor therapy, based on an FDA-authorized test.",
"date_published": "2026-09-04T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-09-04",
"precision": "day",
"venue": "FDA",
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{
"id": "camizestrant",
"kind": "drug",
"name": "Camizestrant",
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{
"id": "palbociclib",
"kind": "drug",
"name": "Palbociclib",
"url": "https://onco.cc/drugs/palbociclib/"
},
{
"id": "abemaciclib",
"kind": "drug",
"name": "Abemaciclib",
"url": "https://onco.cc/drugs/abemaciclib/"
},
{
"id": "ribociclib",
"kind": "drug",
"name": "Ribociclib",
"url": "https://onco.cc/drugs/ribociclib/"
},
{
"id": "breast-cancer",
"kind": "cancer",
"name": "Breast cancer",
"url": "https://onco.cc/cancers/breast-cancer/"
},
{
"id": "breast-hr-positive",
"kind": "cancer",
"name": "HR-positive / HER2-negative breast cancer",
"url": "https://onco.cc/cancers/breast-hr-positive/"
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]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-adagrasib-cetuximab-kras-g12c-mutated-colorectal-cancer#onco-edge-withdrawal",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-adagrasib-cetuximab-kras-g12c-mutated-colorectal-cancer",
"title": "Withdrawal: Adagrasib (US)",
"content_text": "Withdrawn: the indication came off the label 2.3 years after its accelerated approval.",
"date_published": "2026-09-01T00:00:00Z",
"tags": [
"withdrawal"
],
"_onco": {
"kind": "withdrawal",
"date": "2026-09-01",
"precision": "day",
"venue": "FDA",
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{
"id": "adagrasib",
"kind": "drug",
"name": "Adagrasib",
"url": "https://onco.cc/drugs/adagrasib/"
},
{
"id": "nsclc",
"kind": "cancer",
"name": "Non-small-cell lung cancer",
"url": "https://onco.cc/cancers/nsclc/"
},
{
"id": "colorectal",
"kind": "cancer",
"name": "Colorectal cancer",
"url": "https://onco.cc/cancers/colorectal/"
},
{
"id": "pancreatic",
"kind": "cancer",
"name": "Pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/pancreatic/"
},
{
"id": "kras-g12c-colorectal",
"kind": "cancer",
"name": "KRAS G12C-mutant colorectal cancer",
"url": "https://onco.cc/cancers/kras-g12c-colorectal/"
},
{
"id": "kras-g12c-nsclc",
"kind": "cancer",
"name": "KRAS G12C-mutant non-small-cell lung cancer",
"url": "https://onco.cc/cancers/kras-g12c-nsclc/"
}
]
}
},
{
"id": "https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2026/220910Orig1s000ltr.pdf#onco-edge-approval",
"url": "https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2026/220910Orig1s000ltr.pdf",
"title": "Approval: Daraxonrasib (US)",
"content_text": "NDA 220910 approved as Rasonque: adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or who are not candidates for multiagent systemic therapy.",
"date_published": "2026-08-26T00:00:00Z",
"tags": [
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"_onco": {
"kind": "approval",
"date": "2026-08-26",
"precision": "day",
"venue": "FDA",
"records": [
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"id": "daraxonrasib",
"kind": "drug",
"name": "Daraxonrasib",
"url": "https://onco.cc/drugs/daraxonrasib/"
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{
"id": "pancreatic",
"kind": "cancer",
"name": "Pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/pancreatic/"
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{
"id": "metastatic-pdac",
"kind": "cancer",
"name": "Metastatic pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/metastatic-pdac/"
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{
"id": "kras-g12c-pdac",
"kind": "cancer",
"name": "KRAS G12C-mutant pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/kras-g12c-pdac/"
},
{
"id": "nsclc",
"kind": "cancer",
"name": "Non-small-cell lung cancer",
"url": "https://onco.cc/cancers/nsclc/"
},
{
"id": "colorectal",
"kind": "cancer",
"name": "Colorectal cancer",
"url": "https://onco.cc/cancers/colorectal/"
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]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-daraxonrasib-metastatic-pancreatic-adenocarcinoma#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-daraxonrasib-metastatic-pancreatic-adenocarcinoma",
"title": "FDA approves daraxonrasib for metastatic pancreatic adenocarcinoma",
"content_text": "On August 26, 2026, the Food and Drug Administration approved daraxonrasib (RASONQUE, Revolution Medicines, Inc.), an inhibitor of the RAS GTPase family, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or who are not candidates for multiagent systemic therapy.",
"date_published": "2026-08-26T00:00:00Z",
"tags": [
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"_onco": {
"kind": "approval",
"date": "2026-08-26",
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"records": [
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"id": "daraxonrasib",
"kind": "drug",
"name": "Daraxonrasib",
"url": "https://onco.cc/drugs/daraxonrasib/"
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{
"id": "pancreatic",
"kind": "cancer",
"name": "Pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/pancreatic/"
},
{
"id": "urethral-adenocarcinoma",
"kind": "cancer",
"name": "Adenocarcinoma of the urethra",
"url": "https://onco.cc/cancers/urethral-adenocarcinoma/"
},
{
"id": "lung-adenocarcinoma",
"kind": "cancer",
"name": "Adenocarcinoma of the lung",
"url": "https://onco.cc/cancers/lung-adenocarcinoma/"
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}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-zanidatamab-hrii-and-tislelizumab-jsgr-her2-positive-gastric-gastroesophageal-junction#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-zanidatamab-hrii-and-tislelizumab-jsgr-her2-positive-gastric-gastroesophageal-junction",
"title": "FDA approves zanidatamab-hrii and tislelizumab-jsgr for HER2-positive gastric, gastroesophageal junction, or esophageal adenocarcinoma",
"content_text": "On August 25, 2026, the Food and Drug Administration approved zanidatamab-hrii (Ziihera, Jazz Pharmaceuticals) in combination with fluoropyrimidine- and platinum-containing chemotherapy and tislelizumab-jsgr (Tevimbra, BeOne Medicines USA, Inc.), as first-line treatment for adults with HER2-positive (IHC 3+ or IHC 2+/ISH+) unresectable locally advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma, as detected by an FDA-approved test, and in combination with fluoropyrimidine-, and platinum-containing chemotherapy, as first-line treatment for adults with HER2-positive (IHC 3+) unresectable locally advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma, as detected by an FDA-approved test.: dolutegravir.",
"date_published": "2026-08-25T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-08-25",
"precision": "day",
"venue": "FDA",
"records": [
{
"id": "tislelizumab",
"kind": "drug",
"name": "Tislelizumab",
"url": "https://onco.cc/drugs/tislelizumab/"
},
{
"id": "zanidatamab",
"kind": "drug",
"name": "Zanidatamab",
"url": "https://onco.cc/drugs/zanidatamab/"
},
{
"id": "platinum-etoposide",
"kind": "drug",
"name": "Platinum + etoposide",
"url": "https://onco.cc/drugs/platinum-etoposide/"
},
{
"id": "oesophageal-adenocarcinoma",
"kind": "cancer",
"name": "Oesophageal and junctional adenocarcinoma",
"url": "https://onco.cc/cancers/oesophageal-adenocarcinoma/"
},
{
"id": "urethral-adenocarcinoma",
"kind": "cancer",
"name": "Adenocarcinoma of the urethra",
"url": "https://onco.cc/cancers/urethral-adenocarcinoma/"
},
{
"id": "lung-adenocarcinoma",
"kind": "cancer",
"name": "Adenocarcinoma of the lung",
"url": "https://onco.cc/cancers/lung-adenocarcinoma/"
},
{
"id": "esophageal",
"kind": "cancer",
"name": "Oesophageal cancer",
"url": "https://onco.cc/cancers/esophageal/"
},
{
"id": "gastric",
"kind": "cancer",
"name": "Gastric & gastro-oesophageal junction cancer",
"url": "https://onco.cc/cancers/gastric/"
},
{
"id": "nsclc",
"kind": "cancer",
"name": "Non-small-cell lung cancer",
"url": "https://onco.cc/cancers/nsclc/"
},
{
"id": "hcc",
"kind": "cancer",
"name": "Hepatocellular carcinoma",
"url": "https://onco.cc/cancers/hcc/"
},
{
"id": "recurrent-metastatic-nasopharyngeal-carcinoma",
"kind": "cancer",
"name": "Recurrent and metastatic nasopharyngeal carcinoma",
"url": "https://onco.cc/cancers/recurrent-metastatic-nasopharyngeal-carcinoma/"
},
{
"id": "cholangiocarcinoma",
"kind": "cancer",
"name": "Biliary tract cancer",
"url": "https://onco.cc/cancers/cholangiocarcinoma/"
},
{
"id": "gallbladder",
"kind": "cancer",
"name": "Gallbladder cancer",
"url": "https://onco.cc/cancers/gallbladder/"
},
{
"id": "biliary-tract-cancer",
"kind": "cancer",
"name": "Biliary tract cancer",
"url": "https://onco.cc/cancers/biliary-tract-cancer/"
},
{
"id": "her2",
"kind": "target",
"name": "HER2",
"url": "https://onco.cc/targets/her2/"
}
]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-iberdomide-daratumumab-and-hyaluronidase-fihj-and-dexamethasone#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-iberdomide-daratumumab-and-hyaluronidase-fihj-and-dexamethasone",
"title": "FDA grants accelerated approval to iberdomide with daratumumab and hyaluronidase-fihj and dexamethasone for multiple myeloma",
"content_text": "On August 13, 2026, the Food and Drug Administration granted accelerated approval to iberdomide (Zenbexus, Bristol-Myers Squibb Company) in combination with daratumumab and hyaluronidase-fihj and dexamethasone for adults with multiple myeloma who have received at least one prior line of therapy including a proteasome inhibitor and an immunomodulatory agent.",
"date_published": "2026-08-13T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-08-13",
"precision": "day",
"venue": "FDA",
"records": [
{
"id": "dexamethasone",
"kind": "drug",
"name": "Dexamethasone",
"url": "https://onco.cc/drugs/dexamethasone/"
},
{
"id": "daratumumab",
"kind": "drug",
"name": "Daratumumab",
"url": "https://onco.cc/drugs/daratumumab/"
},
{
"id": "iberdomide",
"kind": "drug",
"name": "Iberdomide",
"url": "https://onco.cc/drugs/iberdomide/"
},
{
"id": "multiple-myeloma",
"kind": "cancer",
"name": "Multiple myeloma",
"url": "https://onco.cc/cancers/multiple-myeloma/"
},
{
"id": "smouldering-myeloma",
"kind": "cancer",
"name": "Smouldering multiple myeloma",
"url": "https://onco.cc/cancers/smouldering-myeloma/"
},
{
"id": "myeloma-transplant-eligible",
"kind": "cancer",
"name": "Newly diagnosed multiple myeloma, transplant-eligible",
"url": "https://onco.cc/cancers/myeloma-transplant-eligible/"
},
{
"id": "myeloma-transplant-ineligible",
"kind": "cancer",
"name": "Newly diagnosed multiple myeloma, transplant-ineligible",
"url": "https://onco.cc/cancers/myeloma-transplant-ineligible/"
},
{
"id": "plasma-cell-leukaemia",
"kind": "cancer",
"name": "Plasma cell leukaemia",
"url": "https://onco.cc/cancers/plasma-cell-leukaemia/"
},
{
"id": "all-leukemia",
"kind": "cancer",
"name": "Acute lymphoblastic leukaemia",
"url": "https://onco.cc/cancers/all-leukemia/"
},
{
"id": "dlbcl",
"kind": "cancer",
"name": "Diffuse large B-cell lymphoma",
"url": "https://onco.cc/cancers/dlbcl/"
},
{
"id": "hodgkin-lymphoma",
"kind": "cancer",
"name": "Hodgkin lymphoma",
"url": "https://onco.cc/cancers/hodgkin-lymphoma/"
}
]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-vusolimogene-oderparepvec-wtpg-combination-nivolumab-melanoma#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-vusolimogene-oderparepvec-wtpg-combination-nivolumab-melanoma",
"title": "FDA grants accelerated approval to vusolimogene oderparepvec-wtpg in combination with nivolumab for melanoma",
"content_text": "On August 6, 2026, the Food and Drug Administration granted accelerated approval to vusolimogene oderparepvec-wtpg (Tudriqev, Replimune, Inc.), a genetically modified oncolytic viral therapy, in combination with nivolumab for the treatment of adult patients with unresectable advanced cutaneous melanoma who experienced disease progression on a programmed death receptor-1 (PD-1)-blocking antibody-based regimen.",
"date_published": "2026-08-06T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-08-06",
"precision": "day",
"venue": "FDA",
"records": [
{
"id": "vusolimogene-oderparepvec",
"kind": "drug",
"name": "Vusolimogene oderparepvec",
"url": "https://onco.cc/drugs/vusolimogene-oderparepvec/"
},
{
"id": "nivolumab",
"kind": "drug",
"name": "Nivolumab",
"url": "https://onco.cc/drugs/nivolumab/"
},
{
"id": "relatlimab-nivolumab",
"kind": "drug",
"name": "Relatlimab + nivolumab",
"url": "https://onco.cc/drugs/relatlimab-nivolumab/"
},
{
"id": "melanoma",
"kind": "cancer",
"name": "Melanoma",
"url": "https://onco.cc/cancers/melanoma/"
},
{
"id": "nsclc",
"kind": "cancer",
"name": "Non-small-cell lung cancer",
"url": "https://onco.cc/cancers/nsclc/"
},
{
"id": "rcc",
"kind": "cancer",
"name": "Renal cell carcinoma",
"url": "https://onco.cc/cancers/rcc/"
},
{
"id": "hodgkin-lymphoma",
"kind": "cancer",
"name": "Hodgkin lymphoma",
"url": "https://onco.cc/cancers/hodgkin-lymphoma/"
},
{
"id": "colorectal",
"kind": "cancer",
"name": "Colorectal cancer",
"url": "https://onco.cc/cancers/colorectal/"
}
]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications",
"title": "Approval: ArteraAI Breast (US)",
"content_text": "FDA clearance: first digital-pathology-based risk stratification tool for early HR+/HER2- breast cancer.",
"date_published": "2026-07-31T00:00:00Z",
"tags": [
"approval"
],
"_onco": {
"kind": "approval",
"date": "2026-07-31",
"precision": "day",
"venue": "FDA",
"records": [
{
"id": "artera-ai-breast",
"kind": "drug",
"name": "ArteraAI Breast",
"url": "https://onco.cc/drugs/artera-ai-breast/"
},
{
"id": "breast-hr-positive",
"kind": "cancer",
"name": "HR-positive / HER2-negative breast cancer",
"url": "https://onco.cc/cancers/breast-hr-positive/"
},
{
"id": "atezolizumab",
"kind": "drug",
"name": "Atezolizumab",
"url": "https://onco.cc/drugs/atezolizumab/"
},
{
"id": "nsclc",
"kind": "cancer",
"name": "Non-small-cell lung cancer",
"url": "https://onco.cc/cancers/nsclc/"
},
{
"id": "sclc",
"kind": "cancer",
"name": "Small-cell lung cancer",
"url": "https://onco.cc/cancers/sclc/"
},
{
"id": "hcc",
"kind": "cancer",
"name": "Hepatocellular carcinoma",
"url": "https://onco.cc/cancers/hcc/"
},
{
"id": "hcc-advanced",
"kind": "cancer",
"name": "Advanced hepatocellular carcinoma",
"url": "https://onco.cc/cancers/hcc-advanced/"
},
{
"id": "urothelial",
"kind": "cancer",
"name": "Bladder & urothelial cancer",
"url": "https://onco.cc/cancers/urothelial/"
},
{
"id": "belantamab-mafodotin",
"kind": "drug",
"name": "Belantamab mafodotin",
"url": "https://onco.cc/drugs/belantamab-mafodotin/"
},
{
"id": "multiple-myeloma",
"kind": "cancer",
"name": "Multiple myeloma",
"url": "https://onco.cc/cancers/multiple-myeloma/"
},
{
"id": "myeloma-relapsed-refractory",
"kind": "cancer",
"name": "Relapsed or refractory multiple myeloma",
"url": "https://onco.cc/cancers/myeloma-relapsed-refractory/"
},
{
"id": "bcma",
"kind": "target",
"name": "BCMA",
"url": "https://onco.cc/targets/bcma/"
},
{
"id": "cemiplimab",
"kind": "drug",
"name": "Cemiplimab",
"url": "https://onco.cc/drugs/cemiplimab/"
},
{
"id": "melanoma",
"kind": "cancer",
"name": "Melanoma",
"url": "https://onco.cc/cancers/melanoma/"
},
{
"id": "pdl1-high-nsclc",
"kind": "cancer",
"name": "PD-L1-high non-small-cell lung cancer without a driver mutation",
"url": "https://onco.cc/cancers/pdl1-high-nsclc/"
},
{
"id": "cutaneous-scc",
"kind": "cancer",
"name": "Cutaneous squamous cell carcinoma",
"url": "https://onco.cc/cancers/cutaneous-scc/"
},
{
"id": "advanced-cutaneous-scc",
"kind": "cancer",
"name": "Advanced cutaneous squamous cell carcinoma",
"url": "https://onco.cc/cancers/advanced-cutaneous-scc/"
},
{
"id": "durvalumab",
"kind": "drug",
"name": "Durvalumab",
"url": "https://onco.cc/drugs/durvalumab/"
},
{
"id": "cholangiocarcinoma",
"kind": "cancer",
"name": "Biliary tract cancer",
"url": "https://onco.cc/cancers/cholangiocarcinoma/"
},
{
"id": "intrahepatic-cholangiocarcinoma",
"kind": "cancer",
"name": "Intrahepatic cholangiocarcinoma",
"url": "https://onco.cc/cancers/intrahepatic-cholangiocarcinoma/"
},
{
"id": "extrahepatic-cholangiocarcinoma",
"kind": "cancer",
"name": "Extrahepatic cholangiocarcinoma",
"url": "https://onco.cc/cancers/extrahepatic-cholangiocarcinoma/"
},
{
"id": "encorafenib",
"kind": "drug",
"name": "Encorafenib",
"url": "https://onco.cc/drugs/encorafenib/"
},
{
"id": "colorectal",
"kind": "cancer",
"name": "Colorectal cancer",
"url": "https://onco.cc/cancers/colorectal/"
},
{
"id": "braf-v600e-colorectal",
"kind": "cancer",
"name": "BRAF V600E-mutant colorectal cancer",
"url": "https://onco.cc/cancers/braf-v600e-colorectal/"
},
{
"id": "braf-v600e-nsclc",
"kind": "cancer",
"name": "BRAF V600E-mutant non-small-cell lung cancer",
"url": "https://onco.cc/cancers/braf-v600e-nsclc/"
},
{
"id": "pluvicto",
"kind": "drug",
"name": "Lutetium-177 vipivotide tetraxetan",
"url": "https://onco.cc/drugs/pluvicto/"
},
{
"id": "prostate",
"kind": "cancer",
"name": "Prostate cancer",
"url": "https://onco.cc/cancers/prostate/"
},
{
"id": "prostate-mcrpc",
"kind": "cancer",
"name": "Metastatic castration-resistant prostate cancer",
"url": "https://onco.cc/cancers/prostate-mcrpc/"
},
{
"id": "prostate-mhspc",
"kind": "cancer",
"name": "Metastatic hormone-sensitive prostate cancer",
"url": "https://onco.cc/cancers/prostate-mhspc/"
},
{
"id": "psma",
"kind": "target",
"name": "PSMA",
"url": "https://onco.cc/targets/psma/"
},
{
"id": "nivolumab",
"kind": "drug",
"name": "Nivolumab",
"url": "https://onco.cc/drugs/nivolumab/"
},
{
"id": "rcc",
"kind": "cancer",
"name": "Renal cell carcinoma",
"url": "https://onco.cc/cancers/rcc/"
},
{
"id": "hodgkin-lymphoma",
"kind": "cancer",
"name": "Hodgkin lymphoma",
"url": "https://onco.cc/cancers/hodgkin-lymphoma/"
},
{
"id": "optune",
"kind": "drug",
"name": "Optune / Optune Pax",
"url": "https://onco.cc/drugs/optune/"
},
{
"id": "glioblastoma",
"kind": "cancer",
"name": "Glioma & glioblastoma",
"url": "https://onco.cc/cancers/glioblastoma/"
},
{
"id": "pancreatic",
"kind": "cancer",
"name": "Pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/pancreatic/"
},
{
"id": "locally-advanced-pdac",
"kind": "cancer",
"name": "Locally advanced unresectable pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/locally-advanced-pdac/"
},
{
"id": "mesothelioma",
"kind": "cancer",
"name": "Mesothelioma",
"url": "https://onco.cc/cancers/mesothelioma/"
},
{
"id": "pembrolizumab",
"kind": "drug",
"name": "Pembrolizumab",
"url": "https://onco.cc/drugs/pembrolizumab/"
},
{
"id": "msi-high-pdac",
"kind": "cancer",
"name": "Mismatch repair deficient (MSI-high) pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/msi-high-pdac/"
},
{
"id": "tnbc",
"kind": "cancer",
"name": "Triple-negative breast cancer",
"url": "https://onco.cc/cancers/tnbc/"
},
{
"id": "head-and-neck",
"kind": "cancer",
"name": "Head and neck squamous cell carcinoma",
"url": "https://onco.cc/cancers/head-and-neck/"
},
{
"id": "pylarify",
"kind": "drug",
"name": "Piflufolastat F-18 / Pylarify TruVu",
"url": "https://onco.cc/drugs/pylarify/"
},
{
"id": "relacorilant",
"kind": "drug",
"name": "Relacorilant",
"url": "https://onco.cc/drugs/relacorilant/"
},
{
"id": "ovarian",
"kind": "cancer",
"name": "Ovarian cancer",
"url": "https://onco.cc/cancers/ovarian/"
},
{
"id": "platinum-resistant-ovarian-cancer",
"kind": "cancer",
"name": "Platinum-resistant ovarian cancer",
"url": "https://onco.cc/cancers/platinum-resistant-ovarian-cancer/"
},
{
"id": "advanced-adrenocortical-carcinoma",
"kind": "cancer",
"name": "Advanced and metastatic adrenocortical carcinoma",
"url": "https://onco.cc/cancers/advanced-adrenocortical-carcinoma/"
},
{
"id": "revumenib",
"kind": "drug",
"name": "Revumenib",
"url": "https://onco.cc/drugs/revumenib/"
},
{
"id": "aml",
"kind": "cancer",
"name": "Acute myeloid leukaemia",
"url": "https://onco.cc/cancers/aml/"
},
{
"id": "all-leukemia",
"kind": "cancer",
"name": "Acute lymphoblastic leukaemia",
"url": "https://onco.cc/cancers/all-leukemia/"
},
{
"id": "aml-npm1-kmt2a",
"kind": "cancer",
"name": "NPM1-mutated and KMT2A-rearranged acute myeloid leukaemia",
"url": "https://onco.cc/cancers/aml-npm1-kmt2a/"
},
{
"id": "menin",
"kind": "target",
"name": "Menin",
"url": "https://onco.cc/targets/menin/"
},
{
"id": "tarlatamab",
"kind": "drug",
"name": "Tarlatamab",
"url": "https://onco.cc/drugs/tarlatamab/"
},
{
"id": "extensive-stage-sclc",
"kind": "cancer",
"name": "Extensive-stage small-cell lung cancer",
"url": "https://onco.cc/cancers/extensive-stage-sclc/"
},
{
"id": "limited-stage-sclc",
"kind": "cancer",
"name": "Limited-stage small-cell lung cancer",
"url": "https://onco.cc/cancers/limited-stage-sclc/"
},
{
"id": "lung-cancer",
"kind": "cancer",
"name": "Lung cancer",
"url": "https://onco.cc/cancers/lung-cancer/"
},
{
"id": "dll3",
"kind": "target",
"name": "DLL3",
"url": "https://onco.cc/targets/dll3/"
},
{
"id": "teclistamab",
"kind": "drug",
"name": "Teclistamab",
"url": "https://onco.cc/drugs/teclistamab/"
},
{
"id": "cd3",
"kind": "target",
"name": "CD3",
"url": "https://onco.cc/targets/cd3/"
},
{
"id": "trastuzumab-deruxtecan",
"kind": "drug",
"name": "Trastuzumab deruxtecan",
"url": "https://onco.cc/drugs/trastuzumab-deruxtecan/"
},
{
"id": "breast-her2-positive",
"kind": "cancer",
"name": "HER2-positive breast cancer",
"url": "https://onco.cc/cancers/breast-her2-positive/"
},
{
"id": "gastric",
"kind": "cancer",
"name": "Gastric & gastro-oesophageal junction cancer",
"url": "https://onco.cc/cancers/gastric/"
},
{
"id": "gastric-her2-positive",
"kind": "cancer",
"name": "HER2-positive gastric cancer",
"url": "https://onco.cc/cancers/gastric-her2-positive/"
},
{
"id": "vepdegestrant",
"kind": "drug",
"name": "Vepdegestrant",
"url": "https://onco.cc/drugs/vepdegestrant/"
},
{
"id": "hr-positive-metastatic-post-cdk46",
"kind": "cancer",
"name": "HR-positive metastatic breast cancer after CDK4/6 inhibitors",
"url": "https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/"
},
{
"id": "estrogen-receptor",
"kind": "target",
"name": "Estrogen receptor",
"url": "https://onco.cc/targets/estrogen-receptor/"
},
{
"id": "vusolimogene-oderparepvec",
"kind": "drug",
"name": "Vusolimogene oderparepvec",
"url": "https://onco.cc/drugs/vusolimogene-oderparepvec/"
},
{
"id": "advanced-melanoma",
"kind": "cancer",
"name": "Advanced melanoma",
"url": "https://onco.cc/cancers/advanced-melanoma/"
},
{
"id": "zenocutuzumab",
"kind": "drug",
"name": "Zenocutuzumab",
"url": "https://onco.cc/drugs/zenocutuzumab/"
},
{
"id": "kras-wild-type-pdac",
"kind": "cancer",
"name": "KRAS wild-type pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/kras-wild-type-pdac/"
},
{
"id": "metastatic-pdac",
"kind": "cancer",
"name": "Metastatic pancreatic ductal adenocarcinoma",
"url": "https://onco.cc/cancers/metastatic-pdac/"
},
{
"id": "zongertinib",
"kind": "drug",
"name": "Zongertinib",
"url": "https://onco.cc/drugs/zongertinib/"
},
{
"id": "her2-mutant-nsclc",
"kind": "cancer",
"name": "HER2-mutant non-small-cell lung cancer",
"url": "https://onco.cc/cancers/her2-mutant-nsclc/"
},
{
"id": "her2",
"kind": "target",
"name": "HER2",
"url": "https://onco.cc/targets/her2/"
}
]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lutetium-lu-177-vipivotide-tetraxetan-androgen-receptor-pathway-inhibitor-therapy#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lutetium-lu-177-vipivotide-tetraxetan-androgen-receptor-pathway-inhibitor-therapy",
"title": "FDA approves lutetium Lu 177 vipivotide tetraxetan with androgen receptor pathway inhibitor therapy for metastatic androgen pathway modulation-naïve or -sensitive prostate cancer",
"content_text": "On July 31, 2026, the Food and Drug Administration approved lutetium Lu 177 vipivotide tetraxetan (Pluvicto, Novartis Pharmaceuticals Corporation) in combination with androgen receptor pathway inhibitor (ARPI) therapy for adults with prostate-specific membrane antigen (PSMA)-positive metastatic androgen pathway modulation-naïve or-sensitive (mAPMN/S) prostate cancer (previously referred to as metastatic hormone-sensitive prostate cancer).",
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"approval"
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"id": "pluvicto",
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"name": "Lutetium-177 vipivotide tetraxetan",
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},
{
"id": "prostate-mhspc",
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{
"id": "prostate",
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]
}
},
{
"id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-zidesamtinib-ros1-positive-non-small-cell-lung-cancer#onco-edge-approval",
"url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-zidesamtinib-ros1-positive-non-small-cell-lung-cancer",
"title": "FDA approves zidesamtinib for ROS1 -positive non-small cell lung cancer",
"content_text": "On July 22, 2026, the Food and Drug Administration approved zidesamtinib (Jideytro, Nuvalent, Inc.) for adults with locally advanced or metastatic ROS1 -positive non-small cell lung cancer (NSCLC) who received at least one prior ROS1 tyrosine kinase inhibitor (TKI).",
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{
"id": "zidesamtinib",
"kind": "drug",
"name": "Zidesamtinib",
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},
{
"id": "lung-cancer",
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"name": "Lung cancer",
"url": "https://onco.cc/cancers/lung-cancer/"
},
{
"id": "nsclc",
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},
{
"id": "ros1-positive-nsclc",
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}
},
{
"id": "https://wayback.archive-it.org/7993/20201222063544/https:/www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tazemetostat-advanced-epithelioid-sarcoma#onco-edge-withdrawal",
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"title": "Withdrawal: Tazemetostat (US)",
"content_text": "Withdrawn: the indication came off the label 6.4 years after its accelerated approval.",
"date_published": "2026-06-22T00:00:00Z",
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"withdrawal"
],
"_onco": {
"kind": "withdrawal",
"date": "2026-06-22",
"precision": "day",
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"records": [
{
"id": "tazemetostat",
"kind": "drug",
"name": "Tazemetostat",
"url": "https://onco.cc/drugs/tazemetostat/"
},
{
"id": "follicular-lymphoma",
"kind": "cancer",
"name": "Follicular lymphoma",
"url": "https://onco.cc/cancers/follicular-lymphoma/"
},
{
"id": "sarcoma",
"kind": "cancer",
"name": "Sarcomas",
"url": "https://onco.cc/cancers/sarcoma/"
},
{
"id": "ezh2",
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"name": "EZH2",
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}
},
{
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"title": "Withdrawal: Tazemetostat (US)",
"content_text": "Withdrawn: the indication came off the label 6.0 years after its accelerated approval.",
"date_published": "2026-06-22T00:00:00Z",
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"withdrawal"
],
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"kind": "withdrawal",
"date": "2026-06-22",
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{
"id": "tazemetostat",
"kind": "drug",
"name": "Tazemetostat",
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},
{
"id": "follicular-lymphoma",
"kind": "cancer",
"name": "Follicular lymphoma",
"url": "https://onco.cc/cancers/follicular-lymphoma/"
},
{
"id": "sarcoma",
"kind": "cancer",
"name": "Sarcomas",
"url": "https://onco.cc/cancers/sarcoma/"
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{
"id": "ezh2",
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},
{
"id": "https://wayback.archive-it.org/7993/20201222062817/https:/www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma#onco-edge-withdrawal",
"url": "https://wayback.archive-it.org/7993/20201222062817/https:/www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma",
"title": "Withdrawal: Selinexor (US)",
"content_text": "Withdrawn: the indication came off the label 5.9 years after its accelerated approval.",
"date_published": "2026-04-30T00:00:00Z",
"tags": [
"withdrawal"
],
"_onco": {
"kind": "withdrawal",
"date": "2026-04-30",
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"records": [
{
"id": "selinexor",
"kind": "drug",
"name": "Selinexor",
"url": "https://onco.cc/drugs/selinexor/"
},
{
"id": "endometrial",
"kind": "cancer",
"name": "Endometrial cancer",
"url": "https://onco.cc/cancers/endometrial/"
},
{
"id": "multiple-myeloma",
"kind": "cancer",
"name": "Multiple myeloma",
"url": "https://onco.cc/cancers/multiple-myeloma/"
},
{
"id": "dlbcl",
"kind": "cancer",
"name": "Diffuse large B-cell lymphoma",
"url": "https://onco.cc/cancers/dlbcl/"
},
{
"id": "myeloma-relapsed-refractory",
"kind": "cancer",
"name": "Relapsed or refractory multiple myeloma",
"url": "https://onco.cc/cancers/myeloma-relapsed-refractory/"
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{
"id": "tp53",
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"name": "TP53",
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}
},
{
"id": "https://www.oncologypipeline.com/apexonco/bicycle-finally-falls#onco-edge-withdrawal",
"url": "https://www.oncologypipeline.com/apexonco/bicycle-finally-falls",
"title": "Withdrawal: Zelenectide pevedotin (US)",
"content_text": "Programme deprioritised after regulatory feedback on Duravelo-2 design.",
"date_published": "2026-03-01T00:00:00Z",
"tags": [
"withdrawal"
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"_onco": {
"kind": "withdrawal",
"date": "2026-03",
"precision": "month",
"venue": "FDA",
"records": [
{
"id": "zelenectide-pevedotin",
"kind": "drug",
"name": "Zelenectide pevedotin",
"url": "https://onco.cc/drugs/zelenectide-pevedotin/"
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{
"id": "urothelial",
"kind": "cancer",
"name": "Bladder & urothelial cancer",
"url": "https://onco.cc/cancers/urothelial/"
},
{
"id": "nectin4",
"kind": "target",
"name": "Nectin-4",
"url": "https://onco.cc/targets/nectin4/"
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}
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"id": "https://clinicaltrials.gov/study/NCT05388669?tab=results#onco-edge-result",
"url": "https://clinicaltrials.gov/study/NCT05388669?tab=results",
"title": "A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor: Phase 3 result",
"content_text": "For All Regions Other Than the European Union (EU) and Others Accepting Cycle 2 Day 1: Observed Serum Concentration (Ctrough) of Amivantamab at Steady State: Arm A: Lazertinib With Amivantamab SC-CF 206 micrograms per milliliters (mcg/ml) versus Arm B: Lazertinib With Amivantamab Intravenous (IV) Infusion 144 micrograms per milliliters (mcg/ml).",
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{
"id": "lazertinib",
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"name": "Lazertinib",
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"id": "nsclc",
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"name": "Non-small-cell lung cancer",
"url": "https://onco.cc/cancers/nsclc/"
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{
"id": "sclc",
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{
"id": "egfr-mutant-nsclc",
"kind": "cancer",
"name": "EGFR-mutated non-small-cell lung cancer",
"url": "https://onco.cc/cancers/egfr-mutant-nsclc/"
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},
{
"id": "https://clinicaltrials.gov/study/NCT04497844?tab=results#onco-edge-result",
"url": "https://clinicaltrials.gov/study/NCT04497844?tab=results",
"title": "A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair: Phase 3 result",
"content_text": "Breast Cancer Gene (BRCA) Subgroup: Radiographic Progression-free Survival (rPFS) Assessed by Investigator: BRCA Subgroup: Placebo With Abiraterone Acetate Plus Prednisone 25.99 months, hazard ratio 0.515.",
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{
"id": "abiraterone",
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"name": "Abiraterone acetate",
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{
"id": "niraparib",
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"name": "Niraparib",
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{
"id": "prednisone",
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{
"id": "prostate",
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"name": "Prostate cancer",
"url": "https://onco.cc/cancers/prostate/"
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{
"id": "prostate-mhspc",
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"name": "Metastatic hormone-sensitive prostate cancer",
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{
"id": "https://clinicaltrials.gov/study/NCT04194775?tab=results#onco-edge-result",
"url": "https://clinicaltrials.gov/study/NCT04194775?tab=results",
"title": "A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma: Phase 3 result",
"content_text": "Overall Survival (OS): Nofazinlimab + Lenvatinib 21.6 months versus Placebo + Lenvatinib 18.5 months.",
"date_published": "2026-01-01T00:00:00Z",
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"kind": "trial",
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{
"id": "lenvatinib",
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{
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"url": "https://onco.cc/cancers/hcc/"
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{
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"id": "https://clinicaltrials.gov/study/NCT04351555?tab=results#onco-edge-result",
"url": "https://clinicaltrials.gov/study/NCT04351555?tab=results",
"title": "A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-S: Phase 3 result",
"content_text": "Major Pathological Response (MPR) - IASLC Method: Osimertinib + Chemo 25.6 % versus Osimertinib 24.8 % versus Placebo + Chemo 1.7 %.",
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{
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"name": "Osimertinib",
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"name": "Cisplatin",
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{
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{
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"title": "A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma: Phase 3 result",
"content_text": "Adjusted Time-Averaged Nivolumab Serum Concentration Over the First 28 Days (Cavgd28-Nivo) on Natural Logarithmic Scale: Nivo + Rela FDC SC 4.141 ug/ml versus Nivo + Rela FDC IV 3.901 ug/ml.",
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"title": "A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advance: Phase 3 result",
"content_text": "Adjusted Geometric Mean Serum Concentration of Nivolumab Over 28 Days (Cavgd28) on Original Scale: Nivolumab SC 77.373 μg/ml versus Nivolumab IV 36.875 μg/ml versus Nivo SC Process C 75.504 μg/ml versus Nivo SC Process D 75.596 μg/ml.",
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"kind": "trial",
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"id": "https://clinicaltrials.gov/study/NCT04765059?tab=results#onco-edge-result",
"url": "https://clinicaltrials.gov/study/NCT04765059?tab=results",
"title": "A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer: Phase 3 result",
"content_text": "Progression Free Survival (PFS): Treatment Arm A: Osimertinib (AZD9291), Pemetrexed, Cisplatin or Carboplatin 8.4 months versus Treatment Arm B: Placebo for Osimertinib (AZD9291), Pemetrexed, Cisplatin or Carboplatin 4.4 months, hazard ratio 0.43.",
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"url": "https://clinicaltrials.gov/study/NCT05456191?tab=results",
"title": "A Study to Investigate Tolerability and Efficacy of Asciminib: Phase 3 result",
"content_text": "Time to Discontinuation of Study Treatment Due to Adverse Event (TTDAE) (From Interim Analysis): Asciminib 16 participants versus Nilotinib 34 participants, hazard ratio 0.45.",
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"name": "A Study to Investigate Tolerability and Efficacy of Asciminib",
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{
"id": "asciminib",
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"id": "nilotinib",
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"name": "Nilotinib",
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{
"id": "cml",
"kind": "cancer",
"name": "Chronic myeloid leukaemia",
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{
"id": "cml-chronic-phase",
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"name": "Chronic myeloid leukaemia, chronic phase",
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"id": "https://doi.org/10.1038/s41591-026-04428-0#onco-edge-result",
"url": "https://doi.org/10.1038/s41591-026-04428-0",
"title": "ALTAIR: Phase 3 result",
"content_text": "Median disease-free survival 9.30 against 5.55 months (hazard ratio 0.79, p=0.107): primary endpoint not met.",
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{
"id": "trifluridine-tipiracil",
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"name": "Trifluridine/tipiracil",
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{
"id": "signatera",
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"name": "Signatera",
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{
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"title": "EU withdrawal: Duvelisib",
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