# OnCo record renal-medullary-carcinoma (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/renal-medullary-carcinoma/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "renal-medullary-carcinoma" ;
  schema:name "Renal medullary carcinoma (SMARCB1-deficient)"@en ;
  schema:alternateName "SMARCB1-deficient renal medullary carcinoma"@en, "Renal medullary carcinoma"@en, "RMC"@en, "Sickle cell nephropathy-associated carcinoma"@en ;
  schema:description "Renal medullary carcinoma is a rare kidney cancer of young people with the sickle cell trait, driven by loss of SMARCB1. Platinum chemotherapy and removing the kidney are the main treatments. Most have spread when found; in the 52-patient series median survival was 13.0 months, 16.4 with nephrectomy against 7.0 without. So few centres see it that a trial and a second opinion are worth asking for."@en ;
  schema:url <https://onco.cc/cancers/renal-medullary-carcinoma/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Renal_medullary_carcinoma> ;
  schema:citation <https://www.cancer.gov/types/kidney/patient/kidney-treatment-pdq>, <https://doi.org/10.1016/j.eururo.2022.06.016>, <https://doi.org/10.1111/j.1365-2559.2012.04228.x>, <https://doi.org/10.1158/1078-0432.ccr-17-3296>, <https://doi.org/10.1111/bju.13705>, <https://doi.org/10.1097/pas.0b013e3182635954> ;
  onco:tag "subtype-page", "wave4", "kidney", "rare" ;
  onco:related <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/collecting-duct-carcinoma/>, <https://onco.cc/cancers/clear-cell-rcc/>, <https://onco.cc/cancers/papillary-rcc/> ;
  onco:targets <https://onco.cc/targets/smarcb1/> ;
  onco:drugs <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/gemcitabine/> ;
  onco:terms <https://onco.cc/terms/nephrectomy/> ;
  onco:standardOfCare <https://onco.cc/terms/nephrectomy/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/gemcitabine/> .