# OnCo record rb1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/rb1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "rb1" ;
  schema:name "RB1"@en ;
  schema:alternateName "RB transcriptional corepressor 1"@en, "Retinoblastoma-associated protein"@en, "PPP1R130"@en, "RB1" ;
  schema:description "RB1 (Retinoblastoma-associated protein) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Lung cancer, Neuroendocrine tumours and 5 more."@en ;
  schema:url <https://onco.cc/targets/rb1/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9884>, <https://www.uniprot.org/uniprotkb/P06400/entry>, <https://www.ncbi.nlm.nih.gov/gene/5925>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139687> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "transcription" ;
  onco:firstDescribed "1987"^^xsd:gYear ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9884>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139687>, <https://www.uniprot.org/uniprotkb/P06400/entry>, <https://www.ncbi.nlm.nih.gov/gene/5925> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/neuroendocrine/>, <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/skin-cancer/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/prostate/> ;
  onco:pathways <https://onco.cc/pathways/bladder-cancer-signalling/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/pathways/cml-signalling/>, <https://onco.cc/pathways/hepatocellular-carcinoma-signalling/>, <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/>, <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/sclc-signalling/>, <https://onco.cc/pathways/p53-cell-cycle/> ;
  onco:terms <https://onco.cc/terms/histologic-transformation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-tcga-breast-molecular-portraits-nature-2012/>, <https://onco.cc/key-papers/paper-herschkowitz-rb1-loss-basal-like-bcr-2008/>, <https://onco.cc/key-papers/paper-bareche-tnbc-multiomic-heterogeneity-ann-oncol-2018/>, <https://onco.cc/key-papers/paper-george-sclc-genomic-profiles-nature-2015/>, <https://onco.cc/key-papers/paper-lee-clonal-history-small-cell-transformation-jco-2017/>, <https://onco.cc/key-papers/paper-offin-rb1-tp53-transformation-risk-jto-2019/>, <https://onco.cc/key-papers/paper-abida-genomic-correlates-outcome-mcrpc-pnas-2019/>, <https://onco.cc/key-papers/paper-aparicio-aggressive-variant-prostate-tumour-suppressors-ccr-2016/>, <https://onco.cc/key-papers/paper-mateo-genomics-lethal-prostate-diagnosis-castration-resistance-jci-2020/> .