# OnCo record pten-alteration (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/pten-alteration/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "pten-alteration" ;
  schema:name "PTEN alteration (sequencing) and PTEN loss (IHC)"@en ;
  schema:alternateName "PTEN loss"@en, "PTEN deficiency"@en, "PTEN-deficient"@en, "PTEN alteration"@en, "PTEN deletion"@en, "PTEN mutation"@en, "PTEN IHC loss"@en, "PTEN null"@en ;
  schema:description "PTEN can be lost by mutation or deletion (read by sequencing) or as absent protein on a stain. Both readouts select capivasertib: alterations in breast cancer, and protein deficiency in metastatic hormone-sensitive prostate cancer."@en ;
  schema:url <https://onco.cc/biomarkers/pten-alteration/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d698c106-2322-401e-b738-cbd83c843ecf> ;
  onco:tag "biomarker", "pi3k" ;
  onco:related <https://onco.cc/biomarkers/pik3ca-hotspot-mutation/>, <https://onco.cc/biomarkers/akt1-e17k/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/prostate-mhspc/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/tnbc-metastatic/>, <https://onco.cc/cancers/prostate-mcrpc/> ;
  onco:drugs <https://onco.cc/drugs/capivasertib/>, <https://onco.cc/drugs/abiraterone/>, <https://onco.cc/drugs/foundationone-cdx/> ;
  onco:terms <https://onco.cc/terms/pten-loss/>, <https://onco.cc/terms/ihc/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-barroso-sousa-tmb-pten-ici-mtnbc-ccr-2020/>, <https://onco.cc/key-papers/paper-kim-lotus-ipatasertib-tnbc-lancet-oncol-2017/>, <https://onco.cc/key-papers/paper-tcga-breast-molecular-portraits-nature-2012/>, <https://onco.cc/key-papers/paper-ferraldeschi-pten-protein-loss-abiraterone-eur-urol-2015/>, <https://onco.cc/key-papers/paper-ipatential150-ipatasertib-abiraterone-pten-lancet-2021/>, <https://onco.cc/key-papers/paper-carver-pi3k-ar-reciprocal-feedback-prostate-cancer-cell-2011/> .