# OnCo record nct01828099 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/nct01828099/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "nct01828099", "NCT01828099" ;
  schema:name "ASCEND-4"@en ;
  schema:alternateName "CLDK378A2301"@en, "LDK378 Versus Chemotherapy in Previously Untreated Patients With ALK Rearranged Non-small Cell Lung Cancer"@en ;
  schema:description "ASCEND-4 showed that ceritinib, a second-generation ALK pill, kept untreated ALK-positive lung cancer under control about twice as long as platinum chemotherapy, though stomach and gut side effects were common."@en ;
  schema:url <https://onco.cc/trials/nct01828099/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01828099>, <https://doi.org/10.1016/S0140-6736(17)30123-X>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fff5d805-4ffd-4e8e-8e63-6f129697563e> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2013-07-09" ;
  onco:related <https://onco.cc/trials/alex/>, <https://onco.cc/trials/alta-1l/>, <https://onco.cc/trials/crown/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/alk-positive-nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/alk/> ;
  onco:drugs <https://onco.cc/drugs/ceritinib/>, <https://onco.cc/drugs/pemetrexed/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/> ;
  onco:companies <https://onco.cc/companies/novartis/> ;
  onco:terms <https://onco.cc/terms/brain-metastases/>, <https://onco.cc/terms/tki-term/> ;
  onco:people <https://onco.cc/people/jean-charles-soria/>, <https://onco.cc/people/luis-paz-ares/>, <https://onco.cc/people/juergen-wolf/>, <https://onco.cc/people/chong-jen-yu/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-ascend-4-lancet-2017/> .