# OnCo record nct01774721 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/nct01774721/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "nct01774721", "NCT01774721" ;
  schema:name "ARCHER 1050"@en ;
  schema:alternateName "A7471050"@en, "ARCHER1050"@en, "ARCHER1050: A Study of Dacomitinib vs. Gefitinib in 1st-Line Treatment Of Advanced NSCLC"@en, "ARCHER 1050"@en ;
  schema:description "ARCHER 1050 showed that dacomitinib, a second-generation EGFR pill, kept untreated EGFR-mutant lung cancer under control longer than gefitinib, and a later analysis reported longer survival, though rash and diarrhoea were harsher and patients with brain metastases were excluded."@en ;
  schema:url <https://onco.cc/trials/nct01774721/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01774721>, <https://doi.org/10.1016/S1470-2045(17)30608-3>, <https://doi.org/10.1200/JCO.2018.78.7994>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4ab27d2f-e385-4e9c-b324-fa69c10b855a>, <https://doi.org/10.1016/S1470-2045(17)30608-3>, <https://www.nice.org.uk/guidance/ta595> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2013-05-09" ;
  onco:related <https://onco.cc/trials/flaura/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/egfr-mutant-nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/dacomitinib/>, <https://onco.cc/drugs/gefitinib/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:terms <https://onco.cc/terms/egfr-exon19-l858r/>, <https://onco.cc/terms/tki-term/>, <https://onco.cc/terms/brain-metastases/> ;
  onco:trials <https://onco.cc/trials/flaura/>, <https://onco.cc/trials/lux-lung-3/> ;
  onco:people <https://onco.cc/people/wu-yi-long/>, <https://onco.cc/people/tony-mok/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-archer-1050-lancet-oncol-2017/>, <https://onco.cc/key-papers/paper-archer-1050-os-jco-2018/> .