# OnCo record myc-gene (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/myc-gene/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "myc-gene" ;
  schema:name "MYC"@en ;
  schema:alternateName "MYC proto-oncogene, bHLH transcription factor"@en, "Myc proto-oncogene protein"@en, "c-Myc"@en, "bHLHe39"@en, "MYC" ;
  schema:description "MYC (Myc proto-oncogene protein) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Skin cancer, Multiple myeloma and 5 more."@en ;
  schema:url <https://onco.cc/targets/myc-gene/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7553>, <https://www.uniprot.org/uniprotkb/P01106/entry>, <https://www.ncbi.nlm.nih.gov/gene/4609>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136997>, <https://doi.org/10.1073/pnas.79.24.7824>, <https://doi.org/10.1182/blood-2012-06-435842>, <https://doi.org/10.1200/JCO.2011.41.0985>, <https://doi.org/10.1038/s41375-022-01620-2>, <https://doi.org/10.1182/blood-2017-04-779736>, <https://doi.org/10.1182/blood-2010-09-302174>, <https://doi.org/10.1038/nrc1452>, <https://doi.org/10.1038/nrc2542>, <https://doi.org/10.1038/nature11378> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "transcription" ;
  onco:firstDescribed "1983"^^xsd:gYear ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7553>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136997>, <https://www.uniprot.org/uniprotkb/P01106/entry>, <https://www.ncbi.nlm.nih.gov/gene/4609> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/skin-cancer/>, <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/leukaemia/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/sclc/> ;
  onco:pathways <https://onco.cc/pathways/basal-cell-carcinoma-signalling/>, <https://onco.cc/pathways/bladder-cancer-signalling/>, <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/circadian-control/>, <https://onco.cc/pathways/dna-replication-licensing/>, <https://onco.cc/pathways/er-signaling/>, <https://onco.cc/pathways/glutamine-metabolism/>, <https://onco.cc/pathways/micrornas-in-cancer/>, <https://onco.cc/pathways/mrna-translation-eif4f/>, <https://onco.cc/pathways/myc/>, <https://onco.cc/pathways/notch/>, <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/sclc-signalling/>, <https://onco.cc/pathways/transcription-addiction/>, <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/p53-mdm2-axis/>, <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/oncogenic-viruses/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/bcr-signalling/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/cell-cycle-engine-cdks/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-witkiewicz-pancreatic-exomes-utsw-nat-commun-2015/>, <https://onco.cc/key-papers/paper-hayashi-squamous-basal-like-pancreatic-nat-cancer-2020/>, <https://onco.cc/key-papers/paper-andricovich-kdm6a-squamous-pancreatic-cancer-cell-2018/>, <https://onco.cc/key-papers/paper-tcga-colorectal-comprehensive-characterization-nature-2012/> .