# OnCo record mmr (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/mmr/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "mmr" ;
  schema:name "Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2)"@en ;
  schema:alternateName "MMR proteins"@en, "mismatch repair"@en, "MLH1"@en, "MSH2"@en, "MSH6"@en, "PMS2"@en, "Lynch syndrome genes"@en, "MLH1, MSH2, MSH6, PMS2" ;
  schema:description "The four mismatch repair proteins proofread newly copied DNA; when a tumour loses one of them its DNA fills with small errors, and that state (dMMR or MSI-high) is what lets immunotherapy work across many cancers."@en ;
  schema:url <https://onco.cc/targets/mmr/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/DNA_mismatch_repair> ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7127>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7325>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7329>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9122> ;
  onco:tag "biomarker-parent" ;
  onco:targetClass "enzyme" ;
  onco:related <https://onco.cc/biomarkers/msi-high/>, <https://onco.cc/biomarkers/dmmr-ihc/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/endometrial-mmr-deficient/>, <https://onco.cc/cancers/gastric-msi-high/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/dostarlimab/>, <https://onco.cc/drugs/nivolumab/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/mss-pmmr/>, <https://onco.cc/terms/mlh1-promoter-methylation/>, <https://onco.cc/terms/lynch-syndrome/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-ren-tnbc-mmr-msi-440-front-oncol-2021/>, <https://onco.cc/key-papers/paper-kurata-japanese-tnbc-msi-breast-cancer-2020/>, <https://onco.cc/key-papers/paper-staaf-tnbc-whole-genome-scan-b-nat-med-2019/>, <https://onco.cc/key-papers/paper-hu-mismatch-repair-deficiency-pancreatic-adenocarcinoma-ccr-2018/>, <https://onco.cc/key-papers/paper-singhi-targeted-genome-profiling-3594-pdac-gastroenterology-2019/>, <https://onco.cc/key-papers/paper-luchini-msi-dmmr-pancreatic-systematic-review-gut-2021/>, <https://onco.cc/key-papers/paper-philip-kras-wild-type-pancreatic-ccr-2022/>, <https://onco.cc/key-papers/paper-hu-germline-mutations-pancreatic-cancer-risk-jama-2018/>, <https://onco.cc/key-papers/paper-keynote-158-pembrolizumab-msi-high-noncolorectal-jco-2020/>, <https://onco.cc/key-papers/paper-tcga-colorectal-comprehensive-characterization-nature-2012/>, <https://onco.cc/key-papers/paper-giannakis-genomic-correlates-immune-colorectal-cell-rep-2016/>, <https://onco.cc/key-papers/paper-venderbosch-mmr-braf-metastatic-colorectal-pooled-ccr-2014/>, <https://onco.cc/key-papers/paper-koopman-deficient-mismatch-repair-advanced-colorectal-bjc-2009/>, <https://onco.cc/key-papers/paper-weisenberger-cimp-braf-mlh1-colorectal-nat-genet-2006/>, <https://onco.cc/key-papers/paper-herman-mlh1-promoter-hypermethylation-colorectal-pnas-1998/>, <https://onco.cc/key-papers/paper-ligtenberg-epcam-deletion-msh2-silencing-nat-genet-2009/>, <https://onco.cc/key-papers/paper-moreira-lynch-syndrome-identification-jama-2012/>, <https://onco.cc/key-papers/paper-suryavanshi-indian-gallbladder-genomics-jco-go-2025/>, <https://onco.cc/key-papers/paper-goeppert-cholangiocarcinoma-mmr-deficiency-bjc-2019/>, <https://onco.cc/key-papers/paper-weinberg-biliary-profiling-jgo-2019/> .