# OnCo record kras-g12d (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/kras-g12d/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "kras-g12d" ;
  schema:name "KRAS G12D (and other non-G12C KRAS mutations)"@en ;
  schema:alternateName "KRAS G12D"@en, "G12D"@en, "KRAS G12V"@en, "KRAS G13D"@en, "KRAS mutant"@en, "KRAS codon 12 mutation"@en ;
  schema:description "G12D is the commonest KRAS mutation, especially in pancreatic cancer, and has no approved drug yet. In bowel cancer any KRAS or NRAS mutation is a reason not to give EGFR antibodies, which is where the approvals sit."@en ;
  schema:url <https://onco.cc/biomarkers/kras-g12d/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.fda.gov/medical-devices/in-vitro-diagnostics/list-cleared-or-approved-companion-diagnostic-devices-in-vitro-and-imaging-tools> ;
  onco:tag "biomarker", "kras" ;
  onco:related <https://onco.cc/biomarkers/kras-g12c/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/metastatic-pdac/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/panitumumab/>, <https://onco.cc/drugs/therascreen-cdx/> ;
  onco:terms <https://onco.cc/terms/kras-mutation-subtypes/>, <https://onco.cc/terms/wild-type/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-bournet-kras-g12d-prognosis-pancreatic-ctg-2016/>, <https://onco.cc/key-papers/paper-qian-driver-genes-outcomes-resected-pancreatic-jama-oncol-2018/>, <https://onco.cc/key-papers/paper-daraxonrasib-pancreatic-n-engl-j-med-2026/>, <https://onco.cc/key-papers/paper-karapetis-kras-cetuximab-colorectal-nejm-2008/>, <https://onco.cc/key-papers/paper-douillard-prime-panitumumab-ras-nejm-2013/>, <https://onco.cc/key-papers/paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016/> .