# OnCo record kras-g12c (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/kras-g12c/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "kras-g12c" ;
  schema:name "KRAS G12C"@en ;
  schema:alternateName "KRAS G12C"@en, "G12C"@en, "KRAS p.G12C"@en, "KRAS c.34G>T"@en, "KRAS G12C-mutated"@en ;
  schema:description "KRAS G12C swaps glycine 12 for cysteine and was the first KRAS mutation a drug could grip. Sotorasib and adagrasib are approved for it in lung cancer, and with an EGFR antibody in bowel cancer."@en ;
  schema:url <https://onco.cc/biomarkers/kras-g12c/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c80a362c-7ac3-4894-a076-0691e68ef8c1>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0b8bf078-34c2-4f45-9012-38a8ac082b01> ;
  onco:tag "biomarker", "kras" ;
  onco:related <https://onco.cc/biomarkers/kras-g12d/>, <https://onco.cc/biomarkers/braf-v600e/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/kras-g12c-pdac/>, <https://onco.cc/cancers/metastatic-pdac/> ;
  onco:drugs <https://onco.cc/drugs/sotorasib/>, <https://onco.cc/drugs/adagrasib/>, <https://onco.cc/drugs/divarasib/>, <https://onco.cc/drugs/olomorasib/>, <https://onco.cc/drugs/panitumumab/>, <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/therascreen-cdx/>, <https://onco.cc/drugs/guardant360-cdx/> ;
  onco:terms <https://onco.cc/terms/kras-mutation-subtypes/>, <https://onco.cc/terms/ngs/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-codebreak-100-sotorasib-kras-g12c-pancreatic-nejm-2023/>, <https://onco.cc/key-papers/paper-krystal-1-adagrasib-kras-g12c-solid-tumours-jco-2023/>, <https://onco.cc/key-papers/paper-singhi-targeted-genome-profiling-3594-pdac-gastroenterology-2019/>, <https://onco.cc/key-papers/paper-schirripa-kras-g12c-metastatic-colorectal-clin-colorectal-cancer-2020/>, <https://onco.cc/key-papers/paper-codebreak-300-nejm-2023/>, <https://onco.cc/key-papers/paper-krystal-1-crc-yaeger-nejm-2023/>, <https://onco.cc/key-papers/paper-alexandrov-tobacco-smoking-mutational-signatures-science-2016/>, <https://onco.cc/key-papers/paper-kris-lung-cancer-mutation-consortium-jama-2014/>, <https://onco.cc/key-papers/paper-arbour-kras-co-mutation-outcomes-ccr-2018/> .