# OnCo record her2-mutation (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: .
@prefix onco: .
@prefix xsd: .
a schema:MedicalTest ;
onco:kind "biomarker" ;
schema:identifier "her2-mutation" ;
schema:name "HER2 (ERBB2) activating mutation"@en ;
schema:alternateName "HER2 mutation"@en, "ERBB2 mutation"@en, "HER2-mutant"@en, "HER2-mutant NSCLC"@en, "ERBB2 exon 20 insertion"@en, "HER2 tyrosine kinase domain mutation"@en, "HER2 YVMA insertion"@en, "HER2 TKD mutation"@en ;
schema:description "A HER2 mutation is a change in the gene's kinase domain, most often an exon 20 insertion, found in about 2 to 3 percent of lung adenocarcinomas. It is a different thing from HER2 amplification or overexpression, and it selects trastuzumab deruxtecan and, since 2025, zongertinib in lung cancer."@en ;
schema:url ;
schema:dateModified "2026-10-04"^^xsd:date ;
schema:citation , ;
onco:tag "biomarker", "her2" ;
onco:related , , ;
onco:cancers , ;
onco:drugs , , , ;
onco:terms , , ;
onco:keyPapers , , , .