# OnCo record ciita (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/ciita/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "ciita" ;
  schema:name "CIITA"@en ;
  schema:alternateName "class II major histocompatibility complex transactivator"@en, "MHC class II transactivator"@en, "C2TA"@en, "MHC2TA"@en, "CIITA" ;
  schema:description "CIITA (MHC class II transactivator) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma, Skin cancer, Colorectal cancer and 4 more."@en ;
  schema:url <https://onco.cc/targets/ciita/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7067>, <https://www.uniprot.org/uniprotkb/P33076/entry>, <https://www.ncbi.nlm.nih.gov/gene/4261>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179583>, <https://doi.org/10.1182/blood-2010-05-282780>, <https://doi.org/10.1200/JCO.2016.66.4482>, <https://doi.org/10.1038/nature09754>, <https://doi.org/10.1056/NEJMoa1411087> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "kinase" ;
  onco:firstDescribed "1993"^^xsd:gYear ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7067>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179583>, <https://www.uniprot.org/uniprotkb/P33076/entry>, <https://www.ncbi.nlm.nih.gov/gene/4261> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/skin-cancer/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/melanoma/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/jak-stat/>, <https://onco.cc/pathways/antigen-presentation-immunoediting/> .