# OnCo record brca-germline (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/brca-germline/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "brca-germline" ;
  schema:name "Germline BRCA1/2 pathogenic variant (gBRCAm)"@en ;
  schema:alternateName "gBRCA"@en, "gBRCAm"@en, "germline BRCA"@en, "germline BRCA1"@en, "germline BRCA2"@en, "BRCA carrier"@en, "inherited BRCA mutation"@en, "deleterious germline BRCA mutation"@en ;
  schema:description "A germline BRCA1 or BRCA2 variant is inherited and present in every cell, found by a blood test. It selects PARP inhibitors in breast, ovarian, pancreatic and prostate cancer and tells relatives they may carry it too."@en ;
  schema:url <https://onco.cc/biomarkers/brca-germline/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=741ff3e3-dc1a-45a6-84e5-2481b27131aa>, <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=13839d4f-6acf-4ffb-a128-79df59319273> ;
  onco:tag "biomarker", "brca" ;
  onco:related <https://onco.cc/biomarkers/brca-somatic/>, <https://onco.cc/biomarkers/hrd-positive/>, <https://onco.cc/biomarkers/hrr-gene-mutation/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/high-grade-serous-ovarian-cancer/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/prostate-mcrpc/>, <https://onco.cc/cancers/tnbc-early/>, <https://onco.cc/cancers/tnbc-metastatic/>, <https://onco.cc/cancers/brca-palb2-pdac/>, <https://onco.cc/cancers/metastatic-pdac/>, <https://onco.cc/cancers/prostate/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/talazoparib/>, <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/rucaparib/>, <https://onco.cc/drugs/bracanalysis-cdx/> ;
  onco:terms <https://onco.cc/terms/gbrca-mutation/>, <https://onco.cc/terms/germline-vs-somatic/>, <https://onco.cc/terms/hrd/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-couch-tnbc-germline-17-genes-jco-2015/>, <https://onco.cc/key-papers/paper-hahnen-geparsixto-germline-brca-jama-oncol-2017/>, <https://onco.cc/key-papers/paper-sharma-tnbc-registry-germline-brca-bcrt-2014/>, <https://onco.cc/key-papers/paper-bedrosian-asco-sso-germline-testing-breast-jco-2024/>, <https://onco.cc/key-papers/paper-conroy-nhs-r208-mainstream-testing-audit-breast-j-2026/>, <https://onco.cc/key-papers/paper-tutt-nat-med/>, <https://onco.cc/key-papers/paper-hu-germline-mutations-pancreatic-cancer-risk-jama-2018/>, <https://onco.cc/key-papers/paper-shindo-germline-sporadic-pancreatic-jco-2017/>, <https://onco.cc/key-papers/paper-polo-olaparib-maintenance-gbrca-pancreatic-nejm-2019/>, <https://onco.cc/key-papers/paper-polo-overall-survival-olaparib-gbrca-pancreatic-jco-2022/>, <https://onco.cc/key-papers/paper-golan-brca-pancreatic-platinum-survival-bjc-2014/>, <https://onco.cc/key-papers/paper-lowery-prospective-germline-exocrine-pancreatic-jnci-2018/>, <https://onco.cc/key-papers/paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016/>, <https://onco.cc/key-papers/paper-castro-germline-brca-prostate-outcomes-jco-2013/>, <https://onco.cc/key-papers/paper-nicolosi-germline-variants-prostate-testing-guidelines-jama-oncol-2019/>, <https://onco.cc/key-papers/paper-isaacsson-velho-intraductal-germline-dna-repair-prostate-2018/> .