# OnCo record atm (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/atm/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "atm" ;
  schema:name "ATM"@en ;
  schema:alternateName "ATM serine/threonine kinase"@en, "Serine-protein kinase ATM"@en, "TEL1"@en, "TELO1"@en, "ATM" ;
  schema:description "ATM is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response."@en ;
  schema:url <https://onco.cc/targets/atm/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:795>, <https://www.uniprot.org/uniprotkb/Q13315/entry>, <https://www.ncbi.nlm.nih.gov/gene/472>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149311> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "kinase" ;
  onco:firstDescribed "1995"^^xsd:gYear ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:795>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149311>, <https://www.uniprot.org/uniprotkb/Q13315/entry>, <https://www.ncbi.nlm.nih.gov/gene/472> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/leukaemia/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:pathways <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/p53-mdm2-axis/>, <https://onco.cc/pathways/synthetic-lethality-map/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-hu-germline-mutations-pancreatic-cancer-risk-jama-2018/>, <https://onco.cc/key-papers/paper-shindo-germline-sporadic-pancreatic-jco-2017/>, <https://onco.cc/key-papers/paper-biankin-pancreatic-exomes-axon-guidance-nature-2012/>, <https://onco.cc/key-papers/paper-caps-consortium-surveillance-recommendations-gut-2020/>, <https://onco.cc/key-papers/paper-park-hrd-pancreatic-platinum-ccr-2020/>, <https://onco.cc/key-papers/paper-erices-chilean-gallbladder-landscape-front-oncol-2025/>, <https://onco.cc/key-papers/paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016/>, <https://onco.cc/key-papers/paper-jensen-clonal-haematopoiesis-cfdna-interference-prostate-jama-oncol-2021/> .