{"entity":{"id":"symbiotic-lung-04","kind":"trial","name":"Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer","aka":["Symbiotic-Lung-04"],"tldr":"A phase 2/3 trial testing PF-08634404 in non-small-cell lung cancer, now recruiting.","summary":"Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer is a phase 2/3 interventional study registered as NCT07226999, led by Pfizer, and recruiting on the registry. Official title: A global phase 2/3 interventional study of PF-08634404 in combination with chemotherapy in participants with extensive stage small cell lung cancer. Planned enrolment is 550 participants (estimated). The study started in 2025-12-09 and primary completion is expected in 2030-06-14. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07226999","url":"https://clinicaltrials.gov/study/NCT07226999"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["pf-08634404"],"companies":["pfizer"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07226999","phase":"2/3","setting":"A global phase 2/3 interventional study of PF-08634404 in combination with chemotherapy in participants with extensive stage small cell lung cancer","sponsor":"Pfizer","participation":[{"nct":"NCT07226999","source":"https://clinicaltrials.gov/study/NCT07226999","fetchedAt":"2026-10-07T16:55:34.394Z","studySha256":"f12e882325ad774548bac0f8fd90906ce3d644f6b8ffd1e8b70953817e3a83c1","overallStatus":"RECRUITING","lastUpdatePosted":"2026-09-28","leadSponsor":"Pfizer","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":550,"enrolmentType":"ESTIMATED","siteCount":82,"recruitingSiteCount":82,"countries":["Australia","China","France","Germany","Italy","Japan","Puerto Rico","Spain","Taiwan","United States"]}],"started":"2025-12-09","startedType":"actual","enrolled":550,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/symbiotic-lung-04/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"pf-08634404","kind":"drug","name":"PF-08634404","route":"/drugs/pf-08634404/"}],"company":[{"id":"pfizer","kind":"company","name":"Pfizer (incl. Seagen)","route":"/companies/pfizer/"}]}}