{"entity":{"id":"quintessential-2","kind":"trial","name":"A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)","aka":["QUINTESSENTIAL-2"],"tldr":"A phase 3 trial testing Arlocabtagene Autoleucel in multiple myeloma, now recruiting.","summary":"A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2) is a phase 3 interventional study registered as NCT06615479, led by Juno Therapeutics, a Bristol-Myers Squibb with Celgene, and recruiting on the registry. Official title: A Phase 3, Randomised, Open-Label, Multicenter Study to Compare the Efficacy and Safety of Arlocabtagene Autoleucel (BMS-986393), a GPRC5D-directed CAR-T Cell Therapy, Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma. Planned enrolment is 440 participants (estimated). The study started in 2025-03-12 and primary completion is expected in 2027-12-30. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT06615479","url":"https://clinicaltrials.gov/study/NCT06615479"}],"tags":["ctgov-ingest"],"related":[],"cancers":["multiple-myeloma","myeloma-relapsed-refractory"],"sections":[],"technologies":[],"targets":[],"drugs":["arlocabtagene-autoleucel"],"companies":["bms"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06615479","phase":"3","setting":"A Phase 3, Randomized, Open-Label, Multicenter Study to Compare the Efficacy and Safety of Arlocabtagene Autoleucel (BMS-986393), a GPRC5D-directed CAR-T Cell Therapy, Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma","sponsor":"Juno Therapeutics, a Bristol-Myers Squibb","participation":[{"nct":"NCT06615479","source":"https://clinicaltrials.gov/study/NCT06615479","fetchedAt":"2026-10-07T16:54:51.841Z","studySha256":"18721c7c911c80b2b2a0cb1e2ad2f7c01493f57d47ca6d12f9bc0c5eda3bae3a","overallStatus":"RECRUITING","lastUpdatePosted":"2026-09-15","leadSponsor":"Juno Therapeutics, Inc., a Bristol-Myers Squibb Company","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":440,"enrolmentType":"ESTIMATED","siteCount":141,"recruitingSiteCount":130,"countries":["Argentina","Australia","Austria","Belgium","Brazil","Canada","Czechia","Denmark","Finland","France","Germany","Greece","Hungary","Israel","Italy","Japan","Netherlands","Norway","Poland","Portugal","Romania","Saudi Arabia","Singapore","South Korea","Spain","Sweden","Switzerland","Taiwan","Turkey (Türkiye)","United Kingdom","United States"]}],"started":"2025-03-12","startedType":"actual","enrolled":440,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/quintessential-2/","neighbours":{"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"myeloma-relapsed-refractory","kind":"cancer","name":"Relapsed or refractory multiple myeloma","route":"/cancers/myeloma-relapsed-refractory/"}],"drug":[{"id":"arlocabtagene-autoleucel","kind":"drug","name":"Arlocabtagene Autoleucel","route":"/drugs/arlocabtagene-autoleucel/"}],"company":[{"id":"bms","kind":"company","name":"Bristol Myers Squibb","route":"/companies/bms/"}]}}