{"entity":{"id":"nct07815834","kind":"trial","name":"FAPI-Guided Radiotherapy With Cadonilimab and Standard Chemotherapy for Colorectal Peritoneal Metastasis: A Phase III Randomized Controlled Trial (TORHC-PM02)","aka":["TORCH-PM02"],"tldr":"A phase 3 trial of cadonilimab in colorectal cancer, run by Fudan University, not yet recruiting.","summary":"FAPI-Guided Radiotherapy With Cadonilimab and Standard Chemotherapy for Colorectal Peritoneal Metastasis: A Phase III Randomized Controlled Trial (TORHC-PM02) is a phase 3, randomised interventional study registered as NCT07815834 by Fudan University, with a registry enrolment figure of 198 participants, started 2026-09-01 and due to reach its primary completion in 2030-08-01. Interventions recorded: Second-Line Chemotherapy; Radiation Therapy; Cadonilimab (AK104). Conditions listed: Colon Rectal Cancer Adenocarcinoma; Peritoneal (Metastatic) Cancer; Second-line Treatment; Radiation Therapy; Immunotherapy. Primary outcome: Progression-Free Survival (PFS). Colorectal eligibility wording from the registry: \"Histopathologically confirmed colorectal adenocarcinoma\". Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07815834","url":"https://clinicaltrials.gov/study/NCT07815834"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor","imrt-igrt"],"targets":[],"drugs":["cadonilimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07815834","phase":"3","setting":"FAPI-Guided Hypofractionated Radiotherapy Combined With Cadonilimab and Standard Second-Line Chemotherapy Versus Standard Second-Line Chemotherapy for Peritoneal Metastasis From Colorectal Cancer: A Multicenter, Randomized, Open-Label, Phase III Trial (TORHC-PM02)","sponsor":"Fudan University","participation":[{"nct":"NCT07815834","source":"https://clinicaltrials.gov/study/NCT07815834","fetchedAt":"2026-10-07T16:56:52.065Z","studySha256":"744daba9cbf92468db29b81eb9d7177a421af25ea39b98a25e5d119430a21fe3","overallStatus":"NOT_YET_RECRUITING","lastUpdatePosted":"2026-09-11","leadSponsor":"Fudan University","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":198,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":0,"countries":["China"]}],"started":"2026-09-01","startedType":"estimated","enrolled":198,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07815834/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"cadonilimab","kind":"drug","name":"Cadonilimab","route":"/drugs/cadonilimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}