{"entity":{"id":"nct07668752","kind":"trial","name":"A Study to Evaluate GFH375 Versus Docetaxel in Participants With Non-Small Cell Lung Cancer With KRAS G12D Mutation","aka":[],"tldr":"A phase 3 trial testing GFH375 in non-small-cell lung cancer, now recruiting.","summary":"A Study to Evaluate GFH375 Versus Docetaxel in Participants With Non-Small Cell Lung Cancer With KRAS G12D Mutation is a phase 3 interventional study registered as NCT07668752, led by Genfleet Therapeutics (Shanghai), and recruiting on the registry. Official title: A Phase III, Randomised, Open-Label, Multicenter Study to Evaluate GFH375 Versus Docetaxel in Participants With Locally Advanced and Unresectable or Metastatic Non-Small Cell Lung Cancer With KRAS G12D Mutation Failed Prior Standard Therapy. Planned enrolment is 300 participants (estimated). The study started in 2026-07-27 and primary completion is expected in 2030-06-30. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07668752","url":"https://clinicaltrials.gov/study/NCT07668752"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["gfh375"],"companies":["genfleet"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07668752","phase":"3","setting":"A Phase III, Randomized, Open-Label, Multicenter Study to Evaluate GFH375 Versus Docetaxel in Participants With Locally Advanced and Unresectable or Metastatic Non-Small Cell Lung Cancer With KRAS G12D Mutation Failed Prior Standard Therapy","sponsor":"Genfleet Therapeutics (Shanghai)","participation":[{"nct":"NCT07668752","source":"https://clinicaltrials.gov/study/NCT07668752","fetchedAt":"2026-10-07T16:55:56.330Z","studySha256":"b209362f46203427d650dfeb0683d80a891be05b6ff52044f3c55b523a06e2bc","overallStatus":"RECRUITING","lastUpdatePosted":"2026-08-10","leadSponsor":"Genfleet Therapeutics (Shanghai) Inc.","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":300,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2026-07-27","startedType":"actual","enrolled":300,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07668752/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"gfh375","kind":"drug","name":"GFH375","route":"/drugs/gfh375/"}],"company":[{"id":"genfleet","kind":"company","name":"GenFleet Therapeutics","route":"/companies/genfleet/"}]}}