{"entity":{"id":"nct07622771","kind":"trial","name":"Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Sun Yat-sen University, now recruiting.","summary":"Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial is a phase 2, randomised interventional study registered as NCT07622771 by Sun Yat-sen University, with a registry enrolment figure of 84 participants, started 2026-05-26 and due to reach its primary completion in 2028-06-30. Interventions recorded: Adalimumab+NALIRIFOX→Short course radiotherapy →Adalimumab+NALIRIFOX; Adalimumab+NALIRIFOX→Long course chemoradiotherapy →Adalimumab+NALIRIFOX. Conditions listed: Rectal Cancers. Primary outcome: CR rate. Colorectal eligibility wording from the registry: \"Locally advanced rectal adenocarcinoma confirmed by histopathology;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07622771","url":"https://clinicaltrials.gov/study/NCT07622771"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07622771","phase":"2","setting":"Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial","sponsor":"Sun Yat-sen University","participation":[{"nct":"NCT07622771","source":"https://clinicaltrials.gov/study/NCT07622771","fetchedAt":"2026-10-07T16:55:51.217Z","studySha256":"87cab44c3975c4762f4f4d25882a246db6ddb91114de53445a37c74766f32c08","overallStatus":"RECRUITING","lastUpdatePosted":"2026-09-17","leadSponsor":"Sun Yat-sen University","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":84,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2026-05-26","startedType":"actual","enrolled":84,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07622771/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}