{"entity":{"id":"nct07542262","kind":"trial","name":"Low-dose Immunotherapy in Metastatic and Locally Advanced Colorectal and Gastric MSI/dMMR Cancers","aka":["NIVO402025"],"tldr":"A phase 2 trial in colorectal cancer, run by Blokhin's Russian Cancer Research Center, now recruiting.","summary":"Low-dose Immunotherapy in Metastatic and Locally Advanced Colorectal and Gastric MSI/dMMR Cancers is a phase 2, randomised interventional study registered as NCT07542262 by Blokhin's Russian Cancer Research Center, with a registry enrolment figure of 128 participants, started 2025-06-03 and due to reach its primary completion in 2028-03-30. Interventions recorded: Low-dose nivolumab; Low-dose nivolumab with/without chemotherapy; Low-dose nivolumab combined with chemotherapy. Conditions listed: Colorectal Cancer; Gastric Cancer. Primary outcome: Pathological complete response (pCR) - for M0; One-year progression-free survival (PFS) - for M1. Colorectal eligibility wording from the registry: \"* Histologically confirmed adenocarcinoma of the colon/rectum/stomach;\". Sites: Russia. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07542262","url":"https://clinicaltrials.gov/study/NCT07542262"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07542262","phase":"2","setting":"Phase II Open-lable Single-center Clinical Study of the Efficacy and Safety of Low-dose Immunotherapy in the Treatment of Patients With Metastatic and Locally Advanced Colorectal and Gastric Cancers With Microsatellite Unstable Phenotype (MSI)/Deficiency of Mismatch Repair System (dMMR)","sponsor":"Blokhin's Russian Cancer Research Center","participation":[{"nct":"NCT07542262","source":"https://clinicaltrials.gov/study/NCT07542262","fetchedAt":"2026-10-07T16:55:48.292Z","studySha256":"a307f213eaa0afee6b1555ed66b82e984532d65c3269a2ec0fae2860b9ed2058","overallStatus":"ENROLLING_BY_INVITATION","lastUpdatePosted":"2026-04-24","leadSponsor":"Blokhin's Russian Cancer Research Center","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":128,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":0,"countries":["Russia"]}],"started":"2025-06-03","startedType":"actual","enrolled":128,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07542262/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}