{"entity":{"id":"nct07432399","kind":"trial","name":"Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study)","aka":["PILDI"],"tldr":"A phase 2 trial of dexamethasone in colorectal cancer, run by Institute of Oncology Ljubljana, now recruiting.","summary":"Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study) is a phase 2, randomised interventional study registered as NCT07432399 by Institute of Oncology Ljubljana, with a registry enrolment figure of 100 participants, started 2025-09-01 and due to reach its primary completion in 2027-05-01. Interventions recorded: Lidocaine; Dexamethasone; Placebo. Conditions listed: Colon Cancer; Colorectal Cancer; Perioperative Immune Response. Primary outcome: Change in Serum Cytokine Concentrations (IL-6, IL-8, IL-10, TNF-alpha). Colorectal eligibility wording from the registry: \"* Histologically confirmed colon cancer\". Sites: Slovenia. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07432399","url":"https://clinicaltrials.gov/study/NCT07432399"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["dexamethasone"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07432399","phase":"2","setting":"Effect of Perioperative Intravenous Infusion of Lidocaine or High Dose Dexamethasone on the Immune Response in Patients Undergoing Surgery for Colon Cancer - The PILDI Study","sponsor":"Institute of Oncology Ljubljana","participation":[{"nct":"NCT07432399","source":"https://clinicaltrials.gov/study/NCT07432399","fetchedAt":"2026-10-07T16:55:44.977Z","studySha256":"20ce828d4f7c3bc490a032b2fbd2acac4baea5ef41ce9e488e2e4d2a49a154c2","overallStatus":"RECRUITING","lastUpdatePosted":"2026-03-06","leadSponsor":"Institute of Oncology Ljubljana","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":100,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["Slovenia"]}],"started":"2025-09-01","startedType":"actual","enrolled":100,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07432399/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"drug":[{"id":"dexamethasone","kind":"drug","name":"Dexamethasone","route":"/drugs/dexamethasone/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}