{"entity":{"id":"nct07413939","kind":"trial","name":"RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive","aka":["BREnnA"],"tldr":"A phase 2/3 trial testing RO7771950 in HER2-positive breast cancer and HR-positive / HER2-negative breast cancer, now recruiting.","summary":"RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive is a phase 2/3 interventional study registered as NCT07413939, led by Hoffmann-La Roche, and recruiting on the registry. Official title: A Two-part, Seamless, Multicenter, Randomised, Open-label, Adaptive Phase II/III Study of the Blood-brain Barrier Penetrant RO7771950 Versus Tucatinib, Both in Combination With Trastuzumab and Capecitabine, in Patients With Pretreated Unresectable Locally Advanced or Metastatic HER2-Positive Breast Cancer, With or Without Central Nervous System Metastases. Planned enrolment is 650 participants (estimated). The study started in 2026-05-21 and primary completion is expected in 2029-05-01. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07413939","url":"https://clinicaltrials.gov/study/NCT07413939"}],"tags":["ctgov-ingest"],"related":[],"cancers":["breast-her2-positive","breast-hr-positive"],"sections":[],"technologies":[],"targets":[],"drugs":["ro7771950"],"companies":["roche-genentech"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07413939","phase":"2/3","setting":"A Two-part, Seamless, Multicenter, Randomized, Open-label, Adaptive Phase II/III Study of the Blood-brain Barrier Penetrant RO7771950 Versus Tucatinib, Both in Combination With Trastuzumab and Capecitabine, in Patients With Pretreated Unresectable Locally Advanced or Metastatic HER2-Positive Breast Cancer, With or Without Central Nervous System Metastases","sponsor":"Hoffmann-La Roche","participation":[{"nct":"NCT07413939","source":"https://clinicaltrials.gov/study/NCT07413939","fetchedAt":"2026-10-07T16:55:44.977Z","studySha256":"a7a3d248762d519ea09114ad1ee4082707c4ec7007e6afe4106c264909cd5126","overallStatus":"RECRUITING","lastUpdatePosted":"2026-10-06","leadSponsor":"Hoffmann-La Roche","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":650,"enrolmentType":"ESTIMATED","siteCount":206,"recruitingSiteCount":206,"countries":["Argentina","Australia","Austria","Belgium","Brazil","Canada","Chile","China","Czechia","France","Germany","Hungary","Israel","Italy","New Zealand","Poland","Portugal","South Africa","South Korea","Spain","Taiwan","Thailand","Turkey (Türkiye)","United Kingdom","United States"]}],"started":"2026-05-21","startedType":"actual","enrolled":650,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07413939/","neighbours":{"cancer":[{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"drug":[{"id":"ro7771950","kind":"drug","name":"RO7771950","route":"/drugs/ro7771950/"}],"company":[{"id":"roche-genentech","kind":"company","name":"Roche / Genentech","route":"/companies/roche-genentech/"}],"institution":[{"id":"ucsf","kind":"institution","name":"UCSF Helen Diller Family Comprehensive Cancer Center","route":"/institutions/ucsf/"}]}}