{"entity":{"id":"nct07409428","kind":"trial","name":"A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory DLBCL","aka":[],"tldr":"A phase 3 trial testing HMPL-760 in diffuse large B-cell lymphoma, now recruiting.","summary":"A Phase III Study of HMPL-760 Plus R-GemOx VS Placebo Plus R-GemOx in Relapsed/Refractory DLBCL is a phase 3 interventional study registered as NCT07409428, led by Hutchmed, and recruiting on the registry. Official title: A Phase III Randomised, Double-Blind, Positive Controlled Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of HMPL-760 in Combination With R-GemOx Versus Placebo in Combination With R-GemOx in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL). Planned enrolment is 240 participants (estimated). The study started in 2026-03-20 and primary completion is expected in 2028-04-30. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07409428","url":"https://clinicaltrials.gov/study/NCT07409428"}],"tags":["ctgov-ingest"],"related":[],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":["hmpl-760"],"companies":["hutchmed"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07409428","phase":"3","setting":"A Phase III Randomized, Double-Blind, Positive Controlled Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of HMPL-760 in Combination With R-GemOx Versus Placebo in Combination With R-GemOx in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)","sponsor":"Hutchmed","participation":[{"nct":"NCT07409428","source":"https://clinicaltrials.gov/study/NCT07409428","fetchedAt":"2026-10-07T16:55:43.582Z","studySha256":"57096c2a06c93d15becba37d7cc12432d612cde45470605a07ae2cf223d63353","overallStatus":"RECRUITING","lastUpdatePosted":"2026-07-20","leadSponsor":"Hutchmed","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":240,"enrolmentType":"ESTIMATED","siteCount":50,"recruitingSiteCount":37,"countries":["China"]}],"started":"2026-03-20","startedType":"actual","enrolled":240,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07409428/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}],"drug":[{"id":"hmpl-760","kind":"drug","name":"HMPL-760","route":"/drugs/hmpl-760/"}],"company":[{"id":"hutchmed","kind":"company","name":"Hutchmed","route":"/companies/hutchmed/"}]}}