{"entity":{"id":"nct07362940","kind":"trial","name":"A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib","aka":[],"tldr":"A phase 1/2 trial of GEN-725 tablets + Dositinib mesylate tablets in non-small-cell lung cancer, run by Henan Genuine Biotech Co., Ltd., now recruiting.","summary":"A Phase Ⅰ/Ⅱa Clinical Study of GEN-725 in Combination With Dositinib is a phase 1/2 interventional study registered as NCT07362940 by Henan Genuine Biotech Co., Ltd., with 110 participants planned, started 2025-11-27 and due to reach its primary completion in 2027-07-31. Interventions recorded: GEN-725 tablets + Dositinib mesylate tablets.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT07362940","url":"https://clinicaltrials.gov/study/NCT07362940"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["nsclc","egfr-mutant-nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["henan-genuine-biotech"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07362940","phase":"1/2","setting":"A Phase Ⅰ/Ⅱa Clinical Study Evaluating the Efficacy and Safety of GEN-725 in Combination With Dositinib in Patients With Locally Advanced or Metastatic EGFR-Mutant Non-small Cell Lung Cancer","sponsor":"Henan Genuine Biotech Co., Ltd.","participation":[{"nct":"NCT07362940","source":"https://clinicaltrials.gov/study/NCT07362940","fetchedAt":"2026-10-07T16:55:42.201Z","studySha256":"862872b5683fe13da468f9de9948f41d0622d0421e6ceefe5fb582b32b434459","overallStatus":"RECRUITING","lastUpdatePosted":"2026-01-23","leadSponsor":"Henan Genuine Biotech Co., Ltd.","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":110,"enrolmentType":"ESTIMATED","siteCount":5,"recruitingSiteCount":1,"countries":["China"]}],"started":"2025-11-27","startedType":"actual","enrolled":110,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07362940/","neighbours":{"cancer":[{"id":"egfr-mutant-nsclc","kind":"cancer","name":"EGFR-mutated non-small-cell lung cancer","route":"/cancers/egfr-mutant-nsclc/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"company":[{"id":"henan-genuine-biotech","kind":"company","name":"Henan Genuine Biotech","route":"/companies/henan-genuine-biotech/"}]}}