{"entity":{"id":"nct07362459","kind":"trial","name":"A Study to Evaluate the Safety and Tolerability of SCTB14 as First-Line Therapy in Non-Small Cell Lung Cancer","aka":[],"tldr":"A phase 3 trial testing SCTB14 in non-small-cell lung cancer, now recruiting.","summary":"A Study to Evaluate the Safety and Tolerability of SCTB14 as First-Line Therapy in Non-Small Cell Lung Cancer is a phase 3 interventional study registered as NCT07362459, led by Sinocelltech, and recruiting on the registry. Official title: A Phase III, Randomised, Double-blind, Multicenter Clinical Study to Evaluate the Efficacy and Safety of SCTB14 Versus Pembrolizumab as First-Line Therapy in Patients With Driver Gene-Negative, TPS ≥10% Locally Advanced or Metastatic Non-Small Cell Lung Cancer. Planned enrolment is 246 participants (estimated). The study started in 2025-12-30 and primary completion is expected in 2027-07. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07362459","url":"https://clinicaltrials.gov/study/NCT07362459"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["sctb14"],"companies":["sinocelltech"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07362459","phase":"3","setting":"A Phase III, Randomized, Double-blind, Multicenter Clinical Study to Evaluate the Efficacy and Safety of SCTB14 Versus Pembrolizumab as First-Line Therapy in Patients With Driver Gene-Negative, TPS ≥10% Locally Advanced or Metastatic Non-Small Cell Lung Cancer","sponsor":"Sinocelltech","participation":[{"nct":"NCT07362459","source":"https://clinicaltrials.gov/study/NCT07362459","fetchedAt":"2026-10-07T16:55:42.201Z","studySha256":"ea9239e98fd8850c5cf976fbe5f70ec81aed5cc0845aaced654b276dd3cc0197","overallStatus":"RECRUITING","lastUpdatePosted":"2026-01-23","leadSponsor":"Sinocelltech Ltd.","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":246,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2025-12-30","startedType":"actual","enrolled":246,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07362459/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"sctb14","kind":"drug","name":"SCTB14","route":"/drugs/sctb14/"}],"company":[{"id":"sinocelltech","kind":"company","name":"Sinocelltech","route":"/companies/sinocelltech/"}]}}