{"entity":{"id":"nct07346144","kind":"trial","name":"Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma","aka":["ADePT"],"tldr":"A phase 1/2 trial of TGX-007 in glioma & glioblastoma, run by Trogenix ltd, now recruiting.","summary":"Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma is a phase 1/2 interventional study registered as NCT07346144 by Trogenix ltd, with 68 participants planned, started 2026-04-21 and due to reach its primary completion in 2030-03. Interventions recorded: TGX-007 and Valaciclovir.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT07346144","url":"https://clinicaltrials.gov/study/NCT07346144"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["trog"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07346144","phase":"1/2","setting":"A Phase I/II Study of an AAV-1 Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma","sponsor":"Trogenix ltd","participation":[{"nct":"NCT07346144","source":"https://clinicaltrials.gov/study/NCT07346144","fetchedAt":"2026-10-07T16:55:41.039Z","studySha256":"8b643a2c0db313883bdedff2cb0b820b212eb2d1a742967ffb495dd1dfda607a","overallStatus":"RECRUITING","lastUpdatePosted":"2026-06-12","leadSponsor":"Trogenix ltd","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"70 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":68,"enrolmentType":"ESTIMATED","siteCount":2,"recruitingSiteCount":2,"countries":["United Kingdom","United States"]}],"started":"2026-04-21","startedType":"actual","enrolled":68,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07346144/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"company":[{"id":"trog","kind":"company","name":"TROG Cancer Research","route":"/companies/trog/"}]}}