{"entity":{"id":"nct07230639","kind":"trial","name":"Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized,","aka":["MODIFI-CC"],"tldr":"A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial is a phase 2, randomised interventional study registered as NCT07230639 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 52 participants, started 2025-08-30 and due to reach its primary completion in 2030-08-29. Interventions recorded: Node-Sparing Radiotherapy(25Gy/5F) plus Chemotherapy and PD-1 inhibitor; Node-Sparing Radiotherapy(24Gy/4F) plus Chemotherapy and PD-1 inhibitor. Conditions listed: Neoadjuvant Therapies; Immune Checkpoint Therapy; Radiotherapy. Primary outcome: Pathological Complete Response(pCR) Rate. Colorectal eligibility wording from the registry: \"Histologically confirmed colon adenocarcinoma (without squamous or sarcomatoid components)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07230639","url":"https://clinicaltrials.gov/study/NCT07230639"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07230639","phase":"2","setting":"Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","participation":[{"nct":"NCT07230639","source":"https://clinicaltrials.gov/study/NCT07230639","fetchedAt":"2026-10-07T16:55:34.394Z","studySha256":"93c49f30ae2dca5e33104d506bbb04b562e4c19c13bb372f0e336197c9ff7fda","overallStatus":"RECRUITING","lastUpdatePosted":"2025-12-26","leadSponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":52,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2025-08-30","startedType":"actual","enrolled":52,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07230639/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}