{"entity":{"id":"nct07215585","kind":"trial","name":"AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL","aka":["SOUNDTRACK-D2"],"tldr":"A phase 3 trial testing AZD0486 in diffuse large B-cell lymphoma, now recruiting.","summary":"AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL is a phase 3 interventional study registered as NCT07215585, led by AstraZeneca, and recruiting on the registry. Official title: A Phase III, Multicentre, Open-Label, Randomised Study Evaluating the Efficacy and Safety of R-mini-CHOP x2 Followed by AZD0486 Versus R-mini-CHOP x6 in Elderly or Unfit Participants With Newly Diagnosed Large B-cell Lymphoma (SOUNDTRACK-D2). Planned enrolment is 420 participants (estimated). The study started in 2025-11-11 and primary completion is expected in 2030-06-10. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07215585","url":"https://clinicaltrials.gov/study/NCT07215585"}],"tags":["ctgov-ingest"],"related":[],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":["azd0486"],"companies":["astrazeneca"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07215585","phase":"3","setting":"A Phase III, Multicentre, Open-Label, Randomised Study Evaluating the Efficacy and Safety of R-mini-CHOP x2 Followed by AZD0486 Versus R-mini-CHOP x6 in Elderly or Unfit Participants With Newly Diagnosed Large B-cell Lymphoma (SOUNDTRACK-D2)","sponsor":"AstraZeneca","participation":[{"nct":"NCT07215585","source":"https://clinicaltrials.gov/study/NCT07215585","fetchedAt":"2026-10-07T16:55:33.599Z","studySha256":"e72aa90404489a3dd6ac8f578c36d04bb1029e01f4584bc01356287fbbdffa63","overallStatus":"RECRUITING","lastUpdatePosted":"2026-06-18","leadSponsor":"AstraZeneca","collaboratorCount":0,"minimumAge":"65 Years","maximumAge":"130 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":420,"enrolmentType":"ESTIMATED","siteCount":68,"recruitingSiteCount":28,"countries":["Australia","Belgium","Brazil","Canada","China","Hong Kong","Japan","Poland","South Korea","Turkey (Türkiye)","United Kingdom"]}],"started":"2025-11-11","startedType":"actual","enrolled":420,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07215585/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}],"drug":[{"id":"azd0486","kind":"drug","name":"AZD0486","route":"/drugs/azd0486/"}],"company":[{"id":"astrazeneca","kind":"company","name":"AstraZeneca","route":"/companies/astrazeneca/"}]}}