{"entity":{"id":"nct07209215","kind":"trial","name":"ctDNA-Informed Management of Early-Stage Rectal Cancer","aka":["ULTIMATE"],"tldr":"A phase 2 trial in colorectal cancer, run by University of California, Davis, not yet recruiting.","summary":"ctDNA-Informed Management of Early-Stage Rectal Cancer is a phase 2, interventional study registered as NCT07209215 by University of California, Davis, with a registry enrolment figure of 200 participants, started 2026-10 and due to reach its primary completion in 2028-05. Interventions recorded: Signatera Genome ultra-sensitive ctDNA blood test + total neoadjuvant therapy (TNT). Conditions listed: Rectal Adenocarcinoma; Rectal Cancer; Early-stage Rectal Cancer; Locally Advanced Rectal Adenocarcinoma. Primary outcome: Pathologic complete response (pathCR) rate (ctDNA Informed Management Arm); Pathologic complete response (pathCR) rate (Post TNT SOC Surgery Arm); Disease-free survival (DFS) rate (ctDNA Informed Management Arm). Colorectal eligibility wording from the registry: \"* Tumor tissue histologically confirming rectal adenocarcinoma that is available for Natera ctDNA assay\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07209215","url":"https://clinicaltrials.gov/study/NCT07209215"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07209215","phase":"2","setting":"ULtra sensiTive ctDNA-Informed Management eArly-stage recTal cancEr (ULTIMATE)","sponsor":"University of California, Davis","participation":[{"nct":"NCT07209215","source":"https://clinicaltrials.gov/study/NCT07209215","fetchedAt":"2026-10-07T16:55:33.599Z","studySha256":"d5a36cf310e30fbb0945b4c1a4f97136aeb6854ed35aa9617a31a2341c57a873","overallStatus":"NOT_YET_RECRUITING","lastUpdatePosted":"2026-08-05","leadSponsor":"University of California, Davis","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":200,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":0,"countries":["United States"]}],"started":"2026-10","startedType":"estimated","enrolled":200,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07209215/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}