{"entity":{"id":"nct07198321","kind":"trial","name":"A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial in colorectal cancer, run by Genfleet Therapeutics (Shanghai) Inc., not yet recruiting.","summary":"A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study of GFH276 in Patients With RAS-Mutant Advanced Solid Tumors is a phase 1/2, interventional study registered as NCT07198321 by Genfleet Therapeutics (Shanghai) Inc., with a registry enrolment figure of 450 participants, started 2025-09-22 and due to reach its primary completion in 2027-09-22. Interventions recorded: GFH276. Conditions listed: Cancer; PDAC; CRC (Colorectal Cancer); NSCLC. Primary outcome: Phase Ia:The incidence and severity of AEs and SAEs; Phase Ia:The incidence of DLT events; Phase Ib:The incidence and severity of AEs and SAEs. Sites: China. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07198321","url":"https://clinicaltrials.gov/study/NCT07198321"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["genfleet"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07198321","phase":"1/2","setting":"A Single-Arm, Open-Label, Multicenter Phase I/II Clinical Study","sponsor":"Genfleet Therapeutics (Shanghai) Inc.","participation":[{"nct":"NCT07198321","source":"https://clinicaltrials.gov/study/NCT07198321","fetchedAt":"2026-10-07T16:55:32.313Z","studySha256":"d993390ae3adc2d91ad5d707468a35c68ec65dd97691573e8f61cf0898f8bc63","overallStatus":"NOT_YET_RECRUITING","lastUpdatePosted":"2025-09-30","leadSponsor":"Genfleet Therapeutics (Shanghai) Inc.","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":450,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":0,"countries":["China"]}],"started":"2025-09-22","startedType":"estimated","enrolled":450,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07198321/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"company":[{"id":"genfleet","kind":"company","name":"GenFleet Therapeutics","route":"/companies/genfleet/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}