{"entity":{"id":"nct07155200","kind":"trial","name":"Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)","aka":["SLICK"],"tldr":"A phase 1/2 trial of fOLFIRI (5-FU, leucovorin, irinotecan) in lung cancer, run by Washington University School of Medicine, now recruiting.","summary":"Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial) is a phase 1/2, interventional study registered as NCT07155200 by Washington University School of Medicine, with a registry enrolment figure of 42 participants, started 2025-12-18 and due to reach its primary completion in 2028-07-31. Interventions recorded: Cirtuvivint; Irinotecan. Conditions listed: Small-cell Lung Cancer; Small Cell Lung Carcinoma; Small Cell Lung Cancer. Primary outcome: Recommended Phase II dose (RP2D) (Phase I only); Objective response rate (ORR) per RECIST criteria (Phase II and RP2D only). Lung eligibility wording from the registry: \"* Histologically or cytologically confirmed small cell lung cancer that has progressed on at least one line of prior platinum-based chemotherapy, given with or without anti-PD-(L)1 therapy\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT07155200","url":"https://clinicaltrials.gov/study/NCT07155200"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["sclc"],"sections":[],"technologies":[],"targets":[],"drugs":["folfiri"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07155200","phase":"1/2","setting":"Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)","sponsor":"Washington University School of Medicine","participation":[{"nct":"NCT07155200","source":"https://clinicaltrials.gov/study/NCT07155200","fetchedAt":"2026-10-07T16:55:29.886Z","studySha256":"4f04489d13697fc6b79c78092b782d7676877fb9b0fd9ec3ccf61a2f2ef75e5b","overallStatus":"RECRUITING","lastUpdatePosted":"2026-08-12","leadSponsor":"Washington University School of Medicine","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":42,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["United States"]}],"started":"2025-12-18","startedType":"actual","enrolled":42,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07155200/","neighbours":{"cancer":[{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}