{"entity":{"id":"nct07106034","kind":"trial","name":"Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial","aka":["ONTOP"],"tldr":"A phase 2 trial in colorectal cancer, run by Shanghai Pudong Hospital, now recruiting.","summary":"Standard Second-line Therapy With ONgericimab and TOripalimab in pMMR/MSS Colorectal Cancer: a Single-arm Phase II Trial is a phase 2, interventional study registered as NCT07106034 by Shanghai Pudong Hospital, with a registry enrolment figure of 32 participants, started 2025-08-31 and due to reach its primary completion in 2027-07-31. Interventions recorded: Ongericimab + Toripalimab + Bevacizumab + FOLFOX; Ongericimab + Toripalimab + Bevacizumab + FOLFIRI. Conditions listed: Advanced Colorectal Cancer. Primary outcome: overall response rate. Colorectal eligibility wording from the registry: \"Histologically confirmed MSS/pMMR colorectal or rectal cancer, who have progressed on first-line fluoropyrimidine - based combination therapy (including progression during maintenance therapy)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT07106034","url":"https://clinicaltrials.gov/study/NCT07106034"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07106034","phase":"2","setting":"Clinical Study of Second-Line Standard Therapy Combined With Ongericimab and Toripalimab in Patients With MSS/pMMR Colorectal Cancer Following First-Line Treatment Failure","sponsor":"Shanghai Pudong Hospital","participation":[{"nct":"NCT07106034","source":"https://clinicaltrials.gov/study/NCT07106034","fetchedAt":"2026-10-07T16:55:27.525Z","studySha256":"55bf6c8d23954e1b9afe18682ff2a69866c3c25b512bd24aa8039e4d33cc5288","overallStatus":"RECRUITING","lastUpdatePosted":"2026-07-07","leadSponsor":"Shanghai Pudong Hospital","collaboratorCount":1,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":32,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2025-08-31","startedType":"actual","enrolled":32,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07106034/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}