{"entity":{"id":"nct07101432","kind":"trial","name":"Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)","aka":[],"tldr":"This study tests TROP-2-directed treatment; the registry reports that it is recruiting.","summary":"The registry lists NCT07101432 as recruiting, last updated 2026-10-05. Enrolment is 33 planned participants, an estimate. Interventions: Fludarabine, Cyclophosphamide. Primary measures include Safety and Adverse Events (AEs). No results are posted in the registry; this does not exclude separate publications. The brief summary specifies TROP2 CAR/IL-15 TGFBR2-knockout cord-blood NK cells with radiation; the intervention list names only the lymphodepleting drugs.","status":"recruiting","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT07101432","url":"https://clinicaltrials.gov/study/NCT07101432"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["trop2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07101432","phase":"1","setting":"Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)","sponsor":"M.D. Anderson Cancer Center","participation":[{"nct":"NCT07101432","source":"https://clinicaltrials.gov/study/NCT07101432","fetchedAt":"2026-10-08T16:42:13.801Z","studySha256":"bf9d904e3c8e8b8ab20a5276df38a6ce2ec0219ba6cf7dd7d440df6ff6f446cf","overallStatus":"RECRUITING","lastUpdatePosted":"2026-10-05","leadSponsor":"M.D. Anderson Cancer Center","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":33,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["United States"]}],"started":"2025-12-19","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07101432/","neighbours":{"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}]}}