{"entity":{"id":"nct07062965","kind":"trial","name":"A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment","aka":[],"tldr":"A phase 3 trial testing PF-07248144 in HR-positive / HER2-negative breast cancer, now recruiting.","summary":"A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment is a phase 3 interventional study registered as NCT07062965, led by Pfizer, and recruiting on the registry. Official title: An Interventional, Open-Label, Randomised, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator's Choice of Therapy in Adult Participants With Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy. Planned enrolment is 400 participants (estimated). The study started in 2025-08-05 and primary completion is expected in 2027-07-22. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07062965","url":"https://clinicaltrials.gov/study/NCT07062965"}],"tags":["ctgov-ingest"],"related":[],"cancers":["breast-hr-positive","hr-positive-metastatic-post-cdk46"],"sections":[],"technologies":[],"targets":[],"drugs":["pf-07248144"],"companies":["pfizer"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07062965","phase":"3","setting":"An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator's Choice of Therapy in Adult Participants With Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy","sponsor":"Pfizer","participation":[{"nct":"NCT07062965","source":"https://clinicaltrials.gov/study/NCT07062965","fetchedAt":"2026-10-07T16:55:23.338Z","studySha256":"6f798450a597d1c5cc6baf0c87b138183d8c6e43eeaa310145efbf5288c60713","overallStatus":"RECRUITING","lastUpdatePosted":"2026-05-06","leadSponsor":"Pfizer","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":400,"enrolmentType":"ESTIMATED","siteCount":202,"recruitingSiteCount":122,"countries":["Australia","Belgium","Brazil","Bulgaria","Canada","China","Czechia","Finland","France","Germany","Greece","Hungary","India","Israel","Italy","Japan","Mexico","Netherlands","Poland","Slovakia","South Korea","Spain","Sweden","Taiwan","Turkey (Türkiye)","United Kingdom","United States"]}],"started":"2025-08-05","startedType":"actual","enrolled":400,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07062965/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"hr-positive-metastatic-post-cdk46","kind":"cancer","name":"HR-positive metastatic breast cancer after CDK4/6 inhibitors","route":"/cancers/hr-positive-metastatic-post-cdk46/"}],"drug":[{"id":"pf-07248144","kind":"drug","name":"PF-07248144","route":"/drugs/pf-07248144/"}],"company":[{"id":"pfizer","kind":"company","name":"Pfizer (incl. Seagen)","route":"/companies/pfizer/"}]}}