{"entity":{"id":"nct07015190","kind":"trial","name":"Neoadjuvant Darovasertib in Primary Uveal Melanoma","aka":["OptimUM-10"],"tldr":"A phase 3 trial testing Darovasertib in uveal melanoma, now recruiting.","summary":"Neoadjuvant Darovasertib in Primary Uveal Melanoma is a phase 3 interventional study registered as NCT07015190, led by IDEAYA Biosciences, and recruiting on the registry. Official title: A Randomised, Phase 3, Open-label Study of Neoadjuvant Darovasertib in Subjects With Primary Non-metastatic Uveal Melanoma (OptimUM-10). Planned enrolment is 520 participants (estimated). The study started in 2026-01-25 and primary completion is expected in 2030-10. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT07015190","url":"https://clinicaltrials.gov/study/NCT07015190"}],"tags":["ctgov-ingest"],"related":[],"cancers":["uveal-melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["darovasertib"],"companies":["ideaya-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT07015190","phase":"3","setting":"A Randomized, Phase 3, Open-label Study of Neoadjuvant Darovasertib in Subjects With Primary Non-metastatic Uveal Melanoma (OptimUM-10)","sponsor":"IDEAYA Biosciences","participation":[{"nct":"NCT07015190","source":"https://clinicaltrials.gov/study/NCT07015190","fetchedAt":"2026-10-07T16:55:21.080Z","studySha256":"1af0be03a4e7069a71b871ac674907e4ba9e76832d518ba22b9b7682d3652359","overallStatus":"RECRUITING","lastUpdatePosted":"2026-05-06","leadSponsor":"IDEAYA Biosciences","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":520,"enrolmentType":"ESTIMATED","siteCount":94,"recruitingSiteCount":25,"countries":["Australia","Austria","Belgium","Canada","Czechia","Denmark","Estonia","France","Germany","Greece","Israel","Italy","Netherlands","New Zealand","Poland","Slovakia","Slovenia","Spain","Switzerland","United Kingdom","United States"]}],"started":"2026-01-25","startedType":"actual","enrolled":520,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct07015190/","neighbours":{"cancer":[{"id":"uveal-melanoma","kind":"cancer","name":"Uveal melanoma","route":"/cancers/uveal-melanoma/"}],"drug":[{"id":"darovasertib","kind":"drug","name":"Darovasertib","route":"/drugs/darovasertib/"}],"company":[{"id":"ideaya-biosciences","kind":"company","name":"IDEAYA Biosciences","route":"/companies/ideaya-biosciences/"}]}}