{"entity":{"id":"nct06985147","kind":"trial","name":"A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)","aka":[],"tldr":"A phase 2 trial of DISC-3405 in myeloproliferative neoplasms, run by Disc Medicine, Inc, active and no longer recruiting.","summary":"A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV) is a phase 2 interventional study registered as NCT06985147 by Disc Medicine, Inc, with 60 participants enrolled, started 2025-08-12 and due to reach its primary completion in 2027-02. Interventions recorded: DISC-3405.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06985147","url":"https://clinicaltrials.gov/study/NCT06985147"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["myeloproliferative-neoplasms","polycythaemia-vera"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["disc-medicine"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06985147","phase":"2","setting":"A Phase 2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DISC-3405 in Participants With Polycythemia Vera (PV)","sponsor":"Disc Medicine, Inc","participation":[{"nct":"NCT06985147","source":"https://clinicaltrials.gov/study/NCT06985147","fetchedAt":"2026-10-07T16:55:20.203Z","studySha256":"746028860f8e1af8792216417aaeb04288f34f7ea08159e545ff2d679df8875c","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-07-31","leadSponsor":"Disc Medicine, Inc","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":60,"enrolmentType":"ESTIMATED","siteCount":15,"recruitingSiteCount":0,"countries":["United States"]}],"started":"2025-08-12","startedType":"actual","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06985147/","neighbours":{"cancer":[{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"polycythaemia-vera","kind":"cancer","name":"Polycythaemia vera (PV)","route":"/cancers/polycythaemia-vera/"}],"company":[{"id":"disc-medicine","kind":"company","name":"Disc Medicine","route":"/companies/disc-medicine/"}]}}