{"entity":{"id":"nct06777316","kind":"trial","name":"A Study of an FGFR2/3 Inhibitor (CGT4859) in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of CGT4859 in biliary tract cancer, run by Cogent Biosciences, Inc., active and no longer recruiting.","summary":"A Study of an FGFR2/3 Inhibitor (CGT4859) in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT06777316 by Cogent Biosciences, Inc., with 110 participants enrolled, started 2025-01-22 and due to reach its primary completion in 2027-03. Interventions recorded: CGT4859.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06777316","url":"https://clinicaltrials.gov/study/NCT06777316"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["cholangiocarcinoma","intrahepatic-cholangiocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["cgt4859"],"companies":["cogent-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06777316","phase":"1/2","setting":"A Phase 1/2 Study of a Selective FGFR2/3 Inhibitor, CGT4859, in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors Harboring FGFR2 and/or FGFR3 Genetic Alterations","sponsor":"Cogent Biosciences, Inc.","participation":[{"nct":"NCT06777316","source":"https://clinicaltrials.gov/study/NCT06777316","fetchedAt":"2026-10-07T16:55:03.017Z","studySha256":"50777b65ffbd2e5da52690ddf1fac9b656b3d14c1990917b2cac1b2a36427d36","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-04-17","leadSponsor":"Cogent Biosciences, Inc.","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":110,"enrolmentType":"ESTIMATED","siteCount":13,"recruitingSiteCount":0,"countries":["Canada","United States"]}],"started":"2025-01-22","startedType":"actual","enrolled":110,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06777316/","neighbours":{"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"intrahepatic-cholangiocarcinoma","kind":"cancer","name":"Intrahepatic cholangiocarcinoma","route":"/cancers/intrahepatic-cholangiocarcinoma/"}],"drug":[{"id":"cgt4859","kind":"drug","name":"CGT4859","route":"/drugs/cgt4859/"}],"company":[{"id":"cogent-biosciences","kind":"company","name":"Cogent Biosciences","route":"/companies/cogent-biosciences/"}]}}