{"entity":{"id":"nct06608927","kind":"trial","name":"Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma","aka":["PRISM-1"],"tldr":"A phase 3 trial testing Quemliclustat in pancreatic ductal adenocarcinoma, active and no longer recruiting.","summary":"Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma is a phase 3 interventional study registered as NCT06608927, led by Arcus Biosciences with Taiho Pharmaceutical, and active but no longer recruiting on the registry. Official title: A Randomised, Placebo-Controlled, Double-Blind, Multicenter, Phase 3 Trial of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Treatment-Naive Metastatic Pancreatic Ductal Adenocarcinoma. Planned enrolment is 610 participants (estimated). The study started in 2024-12-13 and primary completion is expected in 2030-11-30. No results have been posted on ClinicalTrials.gov.","status":"active","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT06608927","url":"https://clinicaltrials.gov/study/NCT06608927"}],"tags":["ctgov-ingest"],"related":[],"cancers":["pancreatic","metastatic-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":["quemliclustat"],"companies":["arcus-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06608927","phase":"3","setting":"A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Phase 3 Trial of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Treatment-Naive Metastatic Pancreatic Ductal Adenocarcinoma","sponsor":"Arcus Biosciences","participation":[{"nct":"NCT06608927","source":"https://clinicaltrials.gov/study/NCT06608927","fetchedAt":"2026-10-07T16:54:51.841Z","studySha256":"61b7408b4074121d8869370e2e8f573a3c51fd45e3e185d8a72f11bdf0920693","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-09-29","leadSponsor":"Arcus Biosciences, Inc.","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":610,"enrolmentType":"ESTIMATED","siteCount":111,"recruitingSiteCount":0,"countries":["Australia","Austria","Belgium","Canada","Czechia","France","Germany","Italy","Japan","South Korea","Spain","United Kingdom","United States"]}],"started":"2024-12-13","startedType":"actual","enrolled":610,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06608927/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"drug":[{"id":"quemliclustat","kind":"drug","name":"Quemliclustat","route":"/drugs/quemliclustat/"}],"company":[{"id":"arcus-biosciences","kind":"company","name":"Arcus Biosciences","route":"/companies/arcus-biosciences/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}