{"entity":{"id":"nct06590259","kind":"trial","name":"A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy in the Treatment of CRCLM","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Shanghai 6th People's Hospital, now recruiting.","summary":"A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy in the Treatment of CRCLM is a phase 2, interventional study registered as NCT06590259 by Shanghai 6th People's Hospital, with a registry enrolment figure of 20 participants, started 2024-03-12 and due to reach its primary completion in 2027-07. Interventions recorded: Multi-mode tumor treatment system; Sintilimab+mFOLFOX6 or FOLFIRI+bevacizumab or cetuximab. Conditions listed: Colorectal Cancer Liver Metastasis. Primary outcome: Progression Free Survival (PFS). Colorectal eligibility wording from the registry: \"Pathologically or clinically confirmed colorectal cancer liver metastases, with liver lesions unsuitable for surgical resection or intolerance or refusal of surgical resection;\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06590259","url":"https://clinicaltrials.gov/study/NCT06590259"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["thermal-ablation"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06590259","phase":"2","setting":"A Study on the Efficacy and Safety of Multi-mode Ablation Combined With Systemic Therapy Including PD-1 Inhibitor in the Treatment of Colorectal Cancer Liver Metastasis(CRCLM)","sponsor":"Shanghai 6th People's Hospital","participation":[{"nct":"NCT06590259","source":"https://clinicaltrials.gov/study/NCT06590259","fetchedAt":"2026-10-07T16:54:49.791Z","studySha256":"a52bbef9d38bc573830739aff6a7adb5f09f86a3f6bb8647288c7c68e1861116","overallStatus":"RECRUITING","lastUpdatePosted":"2024-09-19","leadSponsor":"Shanghai 6th People's Hospital","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":20,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2024-03-12","startedType":"actual","enrolled":20,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06590259/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"thermal-ablation","kind":"technology","name":"Thermal ablation (RFA, microwave, cryo)","route":"/technologies/thermal-ablation/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}