{"entity":{"id":"nct06569368","kind":"trial","name":"Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by M.D. Anderson Cancer Center, now recruiting.","summary":"Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy is a phase 2, randomised interventional study registered as NCT06569368 by M.D. Anderson Cancer Center, with a registry enrolment figure of 60 participants, started 2024-07-10 and due to reach its primary completion in 2027-10-31. Interventions recorded: Metronidazole. Conditions listed: Rectal Adenocarcinoma. Primary outcome: Safety and adverse events (AEs). Colorectal eligibility wording from the registry: \"* Participants with locally advanced rectal cancers (T3, T4, or N+ disease) with decision to treat with total neoadjuvant therapy\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06569368","url":"https://clinicaltrials.gov/study/NCT06569368"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06569368","phase":"2","setting":"A Phase II Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy","sponsor":"M.D. Anderson Cancer Center","participation":[{"nct":"NCT06569368","source":"https://clinicaltrials.gov/study/NCT06569368","fetchedAt":"2026-10-07T16:54:48.431Z","studySha256":"4ffe157233376d9715bb6c82b7199c6d13376d6cfa8e9013f86e0c4399350a39","overallStatus":"RECRUITING","lastUpdatePosted":"2026-10-06","leadSponsor":"M.D. Anderson Cancer Center","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":60,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["United States"]}],"started":"2024-07-10","startedType":"actual","enrolled":60,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06569368/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}